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伴淋巴结转移的甲状腺乳头状癌的蛋白质组学研究进展
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Abstract:
甲状腺癌是内分泌系统最常见的恶性肿瘤，发病率逐年增加，但准确的术前诊断甲状腺癌仍然是一个挑战。甲状腺乳头状癌(PTC)是最常见的甲状腺癌，淋巴结是否转移是选择手术方式的重要参数，目前尚无理想的快速诊断PTC淋巴结转移的生物标志物。蛋白质组学为解决PTC目前的困境提供了希望，PTC的蛋白质组学研究结果越来越多地用于确定PTC的预后，提高诊断的准确性，或者被用作早期诊断标志物。本文详细介绍伴淋巴结转移的PTC的蛋白质组学研究进展。
Thyroid cancer is the most common malignancy of the endocrine system and its incidence is in-creasing year by year, but accurate preoperative diagnosis of thyroid cancer remains a challenge. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. Lymph node metastasis is an important parameter in the selection of surgical method. Currently, there is no ideal biomarker for the rapid diagnosis of PTC lymph node metastasis. Proteomics provides hope for solving the current dilemma of PTC. The results of proteomic studies of PTC are increasingly used to determine the prognosis of PTC, improve the accuracy of diagnosis, or be used as markers of early diagnosis. In this paper, advances in proteomics of PTC with lymph node metastasis are reviewed in detail.
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