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冠状动脉粥样硬化性心脏病患者血清炎症指标与血脂水平相关性的研究
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Abstract:
目的：探讨冠状动脉粥样硬化性心脏病(Coronary atherosclerotic heart disease, CHD)患者血清中炎症指标水平与血脂水平相关性，进一步证明慢性炎症反应是诱发CHD的重要原因。方法：收集我院33例CHD合并高脂血症患者的血清样本和29例单纯CHD患者的血清样本，采用ELISA法检测血清中炎性因子IL-1β、IL-6和TNF-α的水平，结合hs-CRP的水平，分析炎症指标与患者血脂水平TC、TG和LDL-C的相关性。结果：与单纯CHD组相比，CHD合并高脂血症患者的炎症指标hs-CRP、IL-1β和TNF-α与血脂指标TC、TG和LDL-C存在显著的相关性。结论：体内慢性炎症反应在CHD的发生中具有重要意义。
Objective: To investigate the correlation between serum inflammatory markers and lipid levels in patients with coronary atherosclerotic heart disease (CHD), further proving that chronic inflam-matory response is an important cause of CHD. Method: Serum samples of 33 patients with CHD combined with hyperlipidemia and 29 patients with CHD alone were collected in our hospital. The levels of inflammatory factors IL-1β, IL-6 and TNF-α in serum were detected by ELISA, combined with the levels of hs-CRP, and the correlation between inflammatory indicators and the levels of TC, TG and LDL-C in patients was analyzed. Results: Compared with CHD group, hs-CRP, IL-1β and TNF-α were significantly correlated with TC, TG and LDL-C in CHD patients with hyperlipidemia. Conclusion: Chronic inflammatory response plays an important role in the development of CHD.
| [1] | 魏妤. 动脉粥样硬化性心血管疾病的降胆固醇治疗及进展[J]. 中国临床医生杂志, 2019, 47(4): 379-381. |
| [2] | B？ck, M., Yurdagul, A., Tabas, I., et al. (2019) Inflammation and Its Resolution in Atherosclerosis: Mediators and Therapeutic Opportunities. Nature Reviews Cardiology, 16, 389-406. https://doi.org/10.1038/s41569-019-0169-2 |
| [3] | 张旻, 赵延延, 田少芳, 等. 中国急性心肌梗死患者发病前动脉粥样硬化性心血管疾病危险分层分析[J]. 中国循环杂志, 2021, 36(9): 852-857. |
| [4] | Dong, Y., Chen, H., Gao, J., et al. (2019) Molecular Machinery and Interplay of Apoptosis and Autophagy in Coronary Heart Disease. The Journal of Molecular and Cellular Cardiology, 136, 27-41.
https://doi.org/10.1016/j.yjmcc.2019.09.001 |
| [5] | Zeltner, N., Fattahi, F., Dubois, N.C., et al. (2016) Capturing the Biology of Disease Severity in a PSC-Based Model of Familial Dysautonomia. Nature Medicine, 22, 1421-1427. https://doi.org/10.1038/nm.4220 |
| [6] | Katta, N., Loethen, T., Lavie, C.J., et al. (2021) Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging. Current Problems in Cardiology, 46, Article ID: 100655.
https://doi.org/10.1016/j.cpcardiol.2020.100655 |
| [7] | Qin, Y., Tang, C., Ma, C., et al. (2019) Risk Factors for Coronary Artery Ectasia and the Relationship between Hyperlipidemia and Coronary Artery Ectasia. Coronary Artery Disease, 30, 211-215.
https://doi.org/10.1097/MCA.0000000000000709 |
| [8] | Su, L., Mittal, R., Ramgobin, D., et al. (2021) Current Management Guidelines on Hyperlipidemia: The Silent Killer. Journal of Lipids, 2021, Article ID: 9883352. https://doi.org/10.1155/2021/9883352 |
| [9] | Beverly, J.K. and Budoff, M.J. (2020) Atherosclerosis: Pathophysi-ology of Insulin Resistance, Hyperglycemia, Hyperlipidemia, and Inflammation. Journal of Diabetes, 12, 102-104. https://doi.org/10.1111/1753-0407.12970 |
| [10] | Alfaddagh, A., Martin, S.S., Leucker, T.M., et al. (2020) Inflam-mation and Cardiovascular Disease: From Mechanisms to Therapeutics. American Journal of Preventive Cardiology, 4, Article ID: 100130.
https://doi.org/10.1016/j.ajpc.2020.100130 |
| [11] | Fiordelisi, A., Iaccarino, G., Morisco, C., et al. (2019) NFkappaB Is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases. International Journal of Molecular Sciences, 20, 1599.
https://doi.org/10.3390/ijms20071599 |
| [12] | Shah, P.K. (2019) Inflammation, Infection and Atherosclerosis. Trends in Cardiovascular Medicine, 29, 468-472.
https://doi.org/10.1016/j.tcm.2019.01.004 |
| [13] | Libby, P. (2021) Inflammation in Atherosclerosis—No Longer a Theory. Clinical Chemistry, 67, 131-142.
https://doi.org/10.1093/clinchem/hvaa275 |
| [14] | Carrizales-Sepulveda, E.F., Ordaz-Farias, A., Vera-Pineda, R., et al. (2018) Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. Heart, Lung and Cir-culation, 27, 1327-1334.
https://doi.org/10.1016/j.hlc.2018.05.102 |
| [15] | Karpouzas, G.A., Ormseth, S.R., Hernandez, E., et al. (2020) Impact of Cumulative Inflammation, Cardiac Risk Factors, and Medication Exposure on Coronary Atherosclerosis Progression in Rheumatoid Arthritis. Arthritis & Rheumatology, 72, 400-408. https://doi.org/10.1002/art.41122 |
| [16] | Zhu, M., Lin, J., Wang, C., et al. (2019) The Relationship among Angiotensinogen Genes Polymorphisms and hs-CRP and Coronary Artery Disease. Journal of Clinical Laboratory Analysis, 33, e22881. https://doi.org/10.1002/jcla.22881 |
| [17] | He, P., Fan, S.Y., Guan, J.Q., et al. (2020) Mediation Analysis for the Relationship between Dyslipidemia and Coronary Artery Disease via Hypersensitive C-Reactive Protein in a Case-Control Study. Coronary Artery Disease, 31, 613-619. https://doi.org/10.1097/MCA.0000000000000911 |
| [18] | Rolski, F. and Blyszczuk, P. (2020) Complexity of TNF-alpha Signaling in Heart Disease. Journal of Clinical Medicine, 9, 3267. https://doi.org/10.3390/jcm9103267 |
| [19] | Zeitouni, M., Clare, R.M., Chiswell, K., et al. (2020) Risk Factor Burden and Long-Term Prognosis of Patients with Premature Coronary Artery Disease. Journal of the American Heart Association, 9, e17712.
https://doi.org/10.1161/JAHA.120.017712 |
