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TTN、OBSCN轴在结直肠癌肝转移中免疫功能临床进展
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Abstract:
结肠直肠癌(Colorectal Cancer, CRC)是我国最常见的恶性肿瘤之一，其发病率呈上升趋势。结直肠癌肝转移是患者主要死亡原因，但其分子机制尚未明确。近年来，免疫治疗在结直肠癌治疗中取得重大进展，但对于结直肠癌肝转移患者只有少部分人受益。TTN、OBSCN是常见的突变基因之一，他们的突变状态或可以作为免疫治疗的预测因子，本文将对TTN/OBSCN轴在结直肠癌肝转移中的免疫功能进行综述。
Colorectal cancer (CRC) is one of the most common malignancies in China, and its incidence is on the rise. Colorectal cancer liver metastases are the leading cause of death in patients, but its molecular mechanism has not been defined. In recent years, immunotherapy has made significant progress in colorectal cancer treatment, but only a small number of patients with colorectal cancer liver metastases have benefited. TTN and OBSCN are one of the common mutant genes, their mutation status may be used as predictors of immunotherapy, this article will elaborate the immune function of TTN and OBSCN axis in colorectal cancer liver metastasis.
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