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免疫细胞参与血管性痴呆的机制研究进展
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Abstract:
血管性痴呆(vascular dementia, VaD)是痴呆症的主要类型之一，近些年的研究表明，神经炎症反应主要作用于脑长期缺血缺氧之后，从而继发神经损伤。炎性细胞及炎症因子参与了神经及血管的病理损伤，但其机制尚不明确。本文就神经炎症反应中参与VaD发生发展的各炎症因子进行综述，为VaD的神经炎症机制研究及临床治疗提供新的思路。Vascular dementia is one of the main types of dementia. Recent studies have shown that neuroinflammation mainly acts on the brain after long-term ischemia and hypoxia, resulting in secondary nerve damage. Inflammatory cells and inflammatory factors are involved in the patho-logical damage of nerves and blood vessels, but the mechanism is still unclear. This article reviews the inflammatory factors involved in the occurrence and development of VaD in the neuroinflammatory response, and provides new ideas for the research on the neuroinflammation mechanism and clinical treatment of VaD.
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