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EPAS1与子痫前期相关性研究进展
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Abstract:
子痫前期(Preeclampsia, PE)是妊娠晚期的一种严重并发症，是导致母婴死亡的主要原因之一，对母婴健康造成了极大的威胁。目前，子痫前期的病因尚不完全明确，但大量研究证实低氧应答参与子痫前期的发病过程，而内皮PAS蛋白1 (EPAS1)是调节细胞内氧气代谢的重要因素。EPAS1在调节滋养细胞分化、侵袭以及螺旋状动脉重塑中起着关键作用。因此，进一步研究EPAS1及其相关靶基因在子痫前期发生、发展中的作用，对探索子痫前期的发病机制、预防及治疗该病均具有十分重要的意义。
Preeclampsia (PE) is a serious complication of late pregnancy, which is one of the main causes of maternal and infant death and poses a great threat to maternal and infant health. At present, the etiology of preeclampsia is not completely clear, but a large number of studies have confirmed that hypoxia response is involved in the pathogenesis of preeclampsia, and endothelial PAS protein 1 (EPAS1) is an important factor regulating oxygen metabolism in cells. EPAS1 plays a key role in the regulation of trophoblast differentiation, invasion and spiral artery remodeling. Therefore, further study on the role of EPAS1 and its related target genes in the occurrence and development of preeclampsia is of great significance to explore the pathogenesis, prevention and treatment of preeclampsia.
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