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空洞型肺结核的相关研究进展
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Abstract:
肺空洞是结核病(TB)中最常见的临床特征之一。有大量文献对空洞型肺结核相关的潜在危险因素进行研究，本文就目前提出的一些潜在危险因素进行综述。根据本文中总结，DM (糖尿病)、结核分枝杆菌(MTB)载量、结核分枝杆菌(MTB)的耐药性以及吸烟作为空洞型肺结核疾病的潜在危险因素，与结核性空洞的发生、发展相互关联，互相影响。随着对空洞型肺结核临床相关因素的研究不断地深入，使我们能够确定导致空洞疾病风险增加的分子因素，让我们可以通过对早期存在危险因素的人群进行干预，以降低空洞型肺结核的发病率。
Pulmonary cavity is one of the most common clinical features of tuberculosis. There are a large number of literatures on the potential risk factors related to cavitary pulmonary tuberculosis. This article reviews some potential risk factors proposed at present. According to the summary in this article, DM (diabetes), bacterial load, drug resistance of tuberculosis bacteria and smoking, as potential risk factors of cavitary pulmonary tuberculosis disease, are related to and affect the oc-currence and development of tuberculous cavities. With the continuous deepening of the research on clinical related factors of cavitary pulmonary tuberculosis, we can determine the molecular factors that lead to the increased risk of cavitary disease, so that we can reduce the incidence rate of cavitary pulmonary tuberculosis by intervening the population with early risk factors.
| [1] | World Health Organization (2022) Global Tuberculosis Report 2022. World Health Organization, Geneva. |
| [2] | Han, J., Yuan, L., Li, J., et al. (2021) Transbronchial Tuberculosis Cavity Plugging Therapy for Pulmonary Tuberculosis. Journal of International Medical Research, 49, No. 8. https://doi.org/10.1177/03000605211035889 |
| [3] | Kim, S.-H., Shin, Y.M., Yoo, J.Y., et al. (2021) Clinical Factors Associated with Cavitary Tuberculosis and Its Treatment Outcomes. Journal of Personalized Medicine, 11, 1081. https://doi.org/10.3390/jpm11111081 |
| [4] | Liu, X., Wu, Q. and Liang, C. (2007) Clinical Study of Antituberculosis Gel Interventional Therapy for Multi-Drug Resistant Pulmonary Tuberculosis. Journal of Clinical Pulmonary Medicine, 12, 558-559. |
| [5] | Saeedi, P., Petersohn, I., Salpea, P., et al. (2019) Global and Regional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th Edition. Diabetes Research and Clinical Practice, 157, Article ID: 107843. https://doi.org/10.1016/j.diabres.2019.107843 |
| [6] | Restrepo, B.I. and Schlesinger, L.S. (2013) Host-Pathogen Interactions in Tuberculosis Patients with Type 2 Diabetes Mellitus. Tuberculosis (Edinb), 93, S10-S14. https://doi.org/10.1016/S1472-9792(13)70004-0 |
| [7] | Restrepo, B.I. and Schlesinger, L.S. (2014) Impact of Dia-betes on the Natural History of Tuberculosis. Diabetes Research and Clinical Practice, 106, 191-199. https://doi.org/10.1016/j.diabres.2014.06.011 |
| [8] | Rieder, H.L. (2014) The Dynamics of Tuberculosis Epidemi-ology. Indian Journal of Tuberculosis, 61, 19-29. |
| [9] | Pérez-Guzmán, C., Torres-Cruz, A., Villareal-Velarde, H., et al. (2001) Atypical Radiological Images or Pulmonary Tuberculosis in 192 Diabetic Patients: A Comparative Study. The International Journal of Tuberculosis and Lung Disease, 5, 455-461. |
| [10] | Agrawal, A.K., Nigam, P., Agrawal, M.C., et al. (1988) Overt Diabetes Mellitus in Pulmonary Tuberculosis. Lung India, 6, 177-180. |
| [11] | Wang, C.S., Yang, C.J., Chen, H.C., et al. (2009) Impact of Type 2 Diabetes on Manifestations and Treatment Outcome of Pulmonary Tuber-culosis. Epidemiology & Infection, 137, 203-210.
https://doi.org/10.1017/S0950268808000782 |
| [12] | Wang, J.Y., Hsueh, P.R., Lee, H.C., et al. (2006) Recognising Tuberculosis in the Lower Lung Field: An Age- and Sex-Matched Controlled Study. The International Journal of Tu-berculosis and Lung Disease, 10, 578-584. |
| [13] | Hendy, M. and Stableforth, D. (1983) The Effect of Established Dia-betes Mellitus on the Presentation of Infiltrative Pulmonary Tuberculosis in the Immigrant Asian Community of an Inner City Area of the United Kingdom. British Journal of Diseases of the Chest, 77, 87-90. https://doi.org/10.1016/0007-0971(83)90010-4 |
| [14] | Chang, J.Y., Dou, H.Y., Yen, C.L., et al. (2011) Effect of Type 2 Diabetes Mellitus on the Clinical Severity and Treatment Outcome in Patients with Pulmonary Tuberculosis: A Potential Role in the Emergence of Multidrug-Resistance. Journal of the Formosan Medical Association, 110, 372-378. https://doi.org/10.1016/S0929-6646(11)60055-7 |
| [15] | Umut, S., Tosun, G.A. and Yildirim, N. (1994) Radiographic Location of Pulmonary Tuberculosis in Diabetic Patients. Chest, 106, 326. https://doi.org/10.1378/chest.106.1.326a |
| [16] | Shaikh, M.A., Singla, R., Khan, N.B., et al. (2003) Does Diabetes alter the Radiological Presentation of Pulmonary Tuberculosis. Saudi Medical Journal, 24, 278-281. |
| [17] | Jiménez-Corona, M.E., Cruz-Hervert, L.P., García-García, L., et al. (2013) Association of Diabetes and Tuberculosis: Impact on Treatment and Post-Treatment Outcomes. Thorax, 68, 214-220.
https://doi.org/10.1136/thoraxjnl-2012-201756 |
| [18] | Perez-Guzman, C., Torres-Cruz, A., Villarreal-Velarde, H. and Vargas, M.H. (2000) Progressive Age-Related Changes in Pulmonary Tuberculosis Images and the Effect of Diabetes. American Journal of Respiratory and Critical Care Medicine, 162, 1738-1740. https://doi.org/10.1164/ajrccm.162.5.2001040 |
| [19] | Wilcke, J.T., Askgaard, D.S., Nybo, J.B., et al. (1998) Radio-graphic Spectrum of Adult Pulmonary Tuberculosis in a Developed Country. Respiratory Medicine, 92, 493-497. https://doi.org/10.1016/S0954-6111(98)90297-9 |
| [20] | Tsukaguchi, K., Okamura, H., Matsuzawa, K., et al. (2002) Longitudinal Assessment of IFN-Gamma Production in Patients with Pulmonary Tuberculosis Complicated with Dia-betes Mellitus. Kekkaku, 77, 409-413. (In Japanese) |
| [21] | Yamashiro, S., Kawakami, K., Uezu, K., et al. (2005) Lower Expression of Th1-Related Cytokines and Inducible Nitric Oxide Synthase in Mice with Streptozotocin-Induced Diabetes Mellitus Infected with Mycobacterium tuberculosis. Clinical & Experimental Immunology, 39, 57-64. https://doi.org/10.1111/j.1365-2249.2005.02677.x |
| [22] | Podell, B.K., Ackart, D.F., Kirk, N.M., et al. (2012) Non-Diabetic Hyperglycemia Exacerbates Disease Severity in Mycobacterium tuberculosis Infected Guinea Pigs. PLOS ONE, 7, e46824.
https://doi.org/10.1371/journal.pone.0046824 |
| [23] | Chiang, C.-Y., Lee, J.-J., Chien, S.-T., et al. (2014) Glycemic Control and Radiographic Manifestations of Tuberculosis in Diabetic Patients. PLOS ONE, 9, e93397. https://doi.org/10.1371/journal.pone.0093397 |
| [24] | Palaci, M., Dietze, R., Hadad, D.J., et al. (2007) Cavitary Disease and Quantitative Sputum Bacillary Load in Cases of Pulmonary Tuberculosis. Journal of Clinical Microbiology, 45, 4064-4066. https://doi.org/10.1128/JCM.01780-07 |
| [25] | Canetti, G. (1965) Present Aspects of Bacterial Resistance in Tuberculosis. American Review of Respiratory Disease, 92, 687-703. https://doi.org/10.1164/arrd.1980.121.3.477 |
| [26] | Greenbaum, M., Beyt Jr., B.E. and Murray, P.R. (1980) The Accuracy of Diagnosing Pulmonary Tuberculosis at a Teaching Hospital. American Review of Respiratory Disease, 121, 477-481 |
| [27] | Matsuoka, S., Uchiyama, K., Shima, H., et al. (2004) Relationship between CT Findings of Pulmonary Tuberculosis and the Number of Acid-Fast Bacilli on Sputum Smears. Clinical Imaging, 28, 119-123.
https://doi.org/10.1016/S0899-7071(03)00148-7 |
| [28] | Rathman, G., Sillah, J., Hill, P.C., Murray, J.F., et al. (2003) Clinical and Radiological Presentation of 340 Adults with Smear-Positive Tuberculosis in the Gambia. The International Journal of Tuberculosis and Lung Disease, 7, 942-947. |
| [29] | 吴吉丽, 黄姣, 马鑫, 张睿, 柴春维. 耐多药与药物敏感性结核肺部空洞CT特征分析[J]. 山西医药杂志, 2022, 51(15): 1718-1720. |
| [30] | Gomes, M., Saad Junior, R. and Stirbulov, R. (2003) Pulmonary Tuberculosis: Relationship between Sputum Bacilloscopy and Radiological Lesions. Revista do Instituto de Medicina Tropical de S？o Paulo, 45, 275-281.
https://doi.org/10.1590/S0036-46652003000500007 |
| [31] | Canetti, G. (1955) The Tubercle Bacillus in the Pulmo-nary Lesion of Man: Histobacteriology and Its Bearing on the Therapy of Pulmonary Tuberculosis. Springer Verlag, New York. https://doi.org/10.1097/00000441-195604000-00012 |
| [32] | Seung, K.J., Keshavjee, S. and Rich, M.L. (2015) Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis. Cold Spring Harbor Perspec-tives in Medicine, 5, a017863. https://doi.org/10.1101/cshperspect.a017863 |
| [33] | Zhang, L., Pang, Y., Yu, X., et al. (2016) Risk Factors for Pulmonary Cavitation in Tuberculosis Patients from China. Emerging Microbes & Infections, 5, e110. https://doi.org/10.1038/emi.2016.111 |
| [34] | Vadwai, V., Daver, G., Udwadia, Z., et al. (2011) Clonal Popu-lation of Mycobacterium tuberculosis Strains Reside within Multiple Lung Cavities. PLOS ONE, 6, e24770. https://doi.org/10.1371/journal.pone.0024770 |
| [35] | 杨钧, 张海青, 周新华, 吕平欣. 肺结核空洞的CT表现及病理基础[J]. 中国医学影像技术, 2007, 23(12): 1831-1833. |
| [36] | 李成海, 周新华, 吕岩, 等. 不同耐药类型及药物敏感肺结核患者的CT征象分析[J]. 中国防痨杂志, 2018, 40(7): 707-712. |
| [37] | 董莘, 陈红兵, 洪剑, 敖国昆. 耐多药继发性肺结核的薄层CT特征[J]. 中华临床医师杂志(电子版), 2013, 7(21): 9494-9497. |
| [38] | Li, D., He, W., Chen, B., et al. (2017) Primary Multidrug-Resistant Tuberculosis versus Drug-Sensitive Tuberculosis in Non-HIV-Infected Patients: Comparisons of CT Findings. PLOS ONE, 12, e0176354.
https://doi.org/10.1371/journal.pone.0176354 |
| [39] | 周婕, 党丽云, 沈聪, 等. 耐多药肺结核患者胸部影像学特征分析[J]. 实用放射学杂志, 2018, 34(9): 1348-1350, 1385. |
| [40] | Chung, M.J., Lee, K.S., Koh, W.J., et al. (2006) Drug-Sensitive Tuberculosis, Multidrugresistant Tuberculosis, and Nontuberculous Mycobacterial Pulmonary Disease in Non-AIDS Adults: Comparisons of Thin-Section CT Findings. European Radiology, 16, 1934-1941. https://doi.org/10.1007/s00330-006-0174-9 |
| [41] | Wáng, Y.X., Chung, M.J., Skrahin, A., et al. (2018) Radiological Signs Associated with Pulmonary Multi-Drug Resistant Tuberculosis: An Analysis of Published Evidences. Quantitative Imaging in Medicine and Surgery, 8, 161-173.
https://doi.org/10.21037/qims.2018.03.06 |
| [42] | de Boer Renee, N., et al. (2014) Delayed Culture Conversion Due to Cigarette Smoking in Active Pulmonary Tuberculosis Patients. Tuberculosis (Edinb), 94, 87-91. https://doi.org/10.1016/j.tube.2013.10.005 |
| [43] | Bates, M.N., Khalakdina, A., Pai, M., et al. (2007) Risk of Tu-berculosis from Exposure to Tobacco Smoke: A Systematic Review and Meta-Analysis. Archives of Internal Medicine, 167, 335e-342.
https://doi.org/10.1001/archinte.167.4.335 |
| [44] | Van Zyl Smit, R.N., Pai, M., Yew, W.W., et al. (2010) Global Lung Health: The Colliding Epidemics of Tuberculosis, Tobacco Smoking, HIV and COPD. European Respiratory Journal, 35, 27-33.
https://doi.org/10.1183/09031936.00072909 |
| [45] | Singla, R., Osman, M.M., Khan, N., et al. (2007) Factors Pre-dicting Persistent Sputum Smear Positivity among Pulmonary Tuberculosis Patients 2 Months after Treatment. The In-ternational Journal of Tuberculosis and Lung Disease,, 7, 48-64. |
| [46] | Hicham, J., Hicham, S., Hatim, K., et al. (2014) La tuberculose pulmonaire et le tabac: à propos de 100 cas. Pan African Medical Journal, 19, Article No. 202. https://doi.org/10.11604/pamj.2014.19.202.5329 |
| [47] | Gajalakshmi, V., Peto, R., Kanaka, T.S. and Jha, R. (2003) Smoking and Mortality from Tuberculosis and Other Diseases in India: Retrospective Study of 43 000 Adult Male Deaths and 35000 Controls. The Lancet Infectious Diseases, 362, 507-515. https://doi.org/10.1016/S0140-6736(03)14109-8 |
| [48] | Abal, A.R., Jayakrishnan, B., Parwer, S., et al. (2005) Effect of Cigarette Smoking on Sputum Smear Conversion in Adults with Active Pulmonary Tuberculosis. Respiratory Medicine, 99, 415-420.
https://doi.org/10.1016/j.rmed.2004.08.016 |
| [49] | Altet-G？mez, M.N., Alcaide, J., Godoy, P., et al. (2005) Clinical and Epidemiological Aspects of Smoking and Tuberculosis: A Study of 13,038 Cases. The International Journal of Tuberculosis and Lung Disease, 9, 430-436. |
