|
|
伴中央–颞区棘波的自限性癫痫发病机制、共患病及药物治疗进展
|
Abstract:
伴中央–颞区棘波的自限性癫痫是儿童最常见的癫痫综合征，以自限性癫痫发作为主要特征，可伴有不同程度的精神、行为及认知障碍。其发病机制可能与遗传因素、大脑微结构损伤、大脑功能网络受损等相关，同时其可合并行为认知等方面并发症，对于患者生活质量有不同程度的影响，抗发作药物治疗的时机、方案还缺乏可靠证据支持。本文通过对伴中央颞区棘波的自限性癫痫最新文献查阅，拟对其发病机制、共患病及治疗方案做一综述。
Self-limiting epilepsy with centrotemporal spikes is the most common epilepsy syndrome in chil-dren, with self-limited seizures as the main feature, and can be accompanied by different levels of mental, behavioral and cognitive disorders. Its pathogenesis may be related to genetic factors, brain micro-structure damage, brain functional network damage, etc. At the same time, it can be combined with behavioral cognitive and other complications, which have different degrees of im-pact on the quality of life for patients. The timing and plan of anti-epileptic drug treatment still lack reliable evidence support. This article reviews the pathogenesis, comorbidity and treatment of self-limited epilepsy with central temporal spikes by reviewing the latest literature.
| [1] | Specchio, N., Wirrell, E.C., Scheffer, I.E., Nabbout, R., Riney, K., Samia, P., Guerreiro, M., Gwer, S., Zuberi, S.M., Wilmshurst, J.M., Yozawitz, E., Pressler, R., Hirsch, E., Wiebe, S., Cross, H.J., Perucca, E., Moshe, S.L., Tinuper, P. and Auvin, S. (2022) International League Against Epilepsy Classification and Definition of Epilepsy Syndromes with Onset in Childhood: Position Paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1398-1442.
https://doi.org/10.1111/epi.17241 |
| [2] | Ross, E.E., Stoyell, S.M., Kramer, M.A., Berg, A.T. and Chu, C.J. (2020) The Natural History of Seizures and Neuropsychiatric Symptoms in Childhood Epilepsy with Centrotemporal Spikes (CECTS). Epilepsy & Behavior, 103, Article ID: 106437. https://doi.org/10.1016/j.yebeh.2019.07.038 |
| [3] | Liu, M.-J., Su, X.-J., Md, X.-Y.S., Wu, G.-F., Zhang, Y.-Q., Gao, L., Wang, W., Liao, J.-X., Wang, H., Mai, J.-N., Gao, J.-Y., Shu, X.-M., Huang, S.-P., Zhang, L. and Zou, L.-P. (2017) Clinical Features of Benign Epilepsy of Childhood with Centrotemporal Spikes in Chinese Children. Medicine, 96, e5623.
https://doi.org/10.1097/MD.0000000000005623 |
| [4] | Xie, W., Ross, E.E., Kramer, M.A., Eden, U.T. and Chu, C.J. (2018) Timing Matters: Impact of Anticonvulsant Drug Treatment and Spikes on Seizure Risk in Benign Epilepsy with Centrotemporal Spikes. Epilepsia Open, 3, 409-417.
https://doi.org/10.1002/epi4.12248 |
| [5] | Shi, X.Y., Wang, G., Li, T., Li, Z., Leo, P., Liu, Z., Wu, G., Zhu, H., Zhang, Y., Li, D., Gao, L., Yang, L., Wang, W., Liao, J., Wang, J., Zhou, S., Wang, H., Li, X., Gao, J., Zhang, L., Shu, X., Li, D., Li, Y., Chen, C., Zhang, X., Partida, G.C., Lundberg, M., Reutens, D., Bartlett, P., Brown, M.A., Zou, L.P. and Xu, H. (2020) Identification of Susceptibility Variants to Benign Childhood Epilepsy with Centro-Temporal Spikes (BECTS) in Chinese Han Population. EBioMedicine, 57, Article ID: 102840. https://doi.org/10.1016/j.ebiom.2020.102840 |
| [6] | Lemke, J.R., Lal, D., Reinthaler, E.M., Steiner, I., Nothnagel, M., Alber, M., Geider, K., Laube, B., Schwake, M., Finsterwalder, K., Franke, A., Schilhabel, M., Jahn, J.A., Muhle, H., Boor, R., Van Paesschen, W., Caraballo, R., Fejerman, N., Weckhuysen, S., De Jonghe, P., Larsen, J., Moller, R.S., Hjalgrim, H., Addis, L., Tang, S., Hughes, E., Pal, D.K., Veri, K., Vaher, U., Talvik, T., Dimova, P., Guerrero Lopez, R., Serratosa, J.M., Linnankivi, T., Lehesjoki, A.E., Ruf, S., Wolff, M., Buerki, S., Wohlrab, G., Kroell, J., Datta, A.N., Fiedler, B., Kurlemann, G., Kluger, G., Hahn, A., Haberlandt, D.E., Kutzer, C., Sperner, J., Becker, F., Weber, Y.G., Feucht, M., Steinbock, H., Neophythou, B., Ronen, G.M., Gruber-Sedlmayr, U., Geldner, J., Harvey, R.J., Hoffmann, P., Herms, S., Altmuller, J., Toliat, M.R., Thiele, H., Nurnberg, P., Wilhelm, C., Stephani, U., Helbig, I., Lerche, H., Zimprich, F., Neubauer, B.A., Biskup, S. and von Spiczak, S. (2013) Mutations in GRIN2A Cause Idiopathic Focal Epilepsy with Rolandic Spikes. Nature Genetics, 45, 1067-1072. https://doi.org/10.1038/ng.2728 |
| [7] | Yang, X., Qian, P., Xu, X., Liu, X., Wu, X., Zhang, Y. and Yang, Z. (2018) GRIN2A Mutations in Epilepsy-Aphasia Spectrum Disorders. Brain and Development, 40, 205-210. https://doi.org/10.1016/j.braindev.2017.09.007 |
| [8] | Thorn, E.L., Ostrowski, L.M., Chinappen, D.M., Jing, J., Westover, M.B., Stufflebeam, S.M., Kramer, M.A. and Chu, C.J. (2020) Persistent Abnormalities in Rolandic Thalamocortical White Matter Circuits in Childhood Epilepsy with Centrotemporal Spikes. Epilepsia, 61, 2500-2508. https://doi.org/10.1111/epi.16681 |
| [9] | Kwon, H., Chinappen, D.M., Huang, J.F., Berja, E.D., Walsh, K.G., Shi, W., Kramer, M.A. and Chu, C.J. (2022) Transient, Developmental Functional and Structural Connectivity Abnormalities in the Thalamocortical Motor Network in Rolandic Epilepsy. NeuroImage: Clinical, 35, Article ID: 103102. https://doi.org/10.1016/j.nicl.2022.103102 |
| [10] | Xu, Y., Xu, Q., Zhang, Q., Stufflebeam, S.M., Yang, F., He, Y., Hu, Z., Weng, Y., Xiao, J., Lu, G. and Zhang, Z. (2021) Influence of Epileptogenic Region on Brain Structural Changes in Rolandic Epilepsy. Brain Imaging and Behavior, 16, 424-434. https://doi.org/10.1007/s11682-021-00517-5 |
| [11] | Kramer, M.A., Stoyell, S.M., Chinappen, D., Ostrowski, L.M., Spencer, E.R., Morgan, A.K., Emerton, B.C., Jing, J., Westover, M.B., Eden, U.T., Stickgold, R., Manoach, D.S. and Chu, C.J. (2021) Focal Sleep Spindle Deficits Reveal Focal Thalamocortical Dysfunction and Predict Cognitive Deficits in Sleep Activated Developmental Epilepsy. Journal of Neuroscience, 41, 1816-1829. https://doi.org/10.1523/JNEUROSCI.2009-20.2020 |
| [12] | Klinzing, J.G., Tashiro, L., Ruf, S., Wolff, M., Born, J. and Ngo, H.-V.V. (2021) Auditory Stimulation during Sleep Suppresses Spike Activity in Benign Epilepsy with Centrotemporal Spikes. Cell Reports Medicine, 2, Article ID: 100432. https://doi.org/10.1016/j.xcrm.2021.100432 |
| [13] | Filippini, M., Boni, A., Giannotta, M. and Gobbi, G. (2013) Neuropsychological Development in Children Belonging to BECTS Spectrum: Long-Term Effect of Epileptiform Ac-tivity. Epilepsy & Behavior: E&B, 28, 504-511.
https://doi.org/10.1016/j.yebeh.2013.06.016 |
| [14] | Van Bogaert, P. (2020) Epilepsy Syndromes of Childhood with Sleep Activation: Insights from Functional Imaging. European Journal of Paediatric Neurology, 24, 58-60. https://doi.org/10.1016/j.ejpn.2019.12.006 |
| [15] | ？zgen, Y., Güng？r, M., Kutlu, M. and Kara, B. (2021) Clinical and Electrophysiological Predictors of Behavioral Disorders in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes. Epilepsy & Behavior: E&B, 121, Article ID: 108037. https://doi.org/10.1016/j.yebeh.2021.108037 |
| [16] | Danhofer, P., Pej？ochová, J., Du？ek, L., Rektor, I. and O？lej？ková, H. (2018) The Influence of EEG-Detected Nocturnal Centrotemporal Discharges on the Expression of Core Symptoms of ADHD in Children with Benign Childhood Epilepsy with Centrotemporal Spikes (BCECTS): A Prospective Study in a Tertiary Referral Center. Epilepsy & Behavior: E&B, 79, 75-81. https://doi.org/10.1016/j.yebeh.2017.11.007 |
| [17] | Huang, C., Hu, W., Tan, G., Xu, Y. and Liu, L. (2020) Clinical and Electroencephalographic Features of Benign Childhood Epilepsy with Centrotemporal Spikes Comorbidity with Attention-Deficit Hyperactivity Disorder in Southwest China. Epilepsy & Behavior, 111, Article ID: 107240. https://doi.org/10.1016/j.yebeh.2020.107240 |
| [18] | Wu, L., Yang, X., Wang, X., Yu, S. and Yang, B. (2021) The Attention Networks in Benign Epilepsy with Centrotemporal Spikes: A Long-Term Follow-Up Study. Journal of Clin-ical Neuroscience, 88, 22-27.
https://doi.org/10.1016/j.jocn.2021.03.022 |
| [19] | Liu, X. and Han, Q. (2016) Depression and Anxiety in Children with Benign Childhood Epilepsy with Centrotemporal Spikes (BCECTS). BMC Pediatrics, 16, 128. https://doi.org/10.1186/s12887-016-0670-2 |
| [20] | Camfield, C.S. and Camfield, P.R. (2014) Rolandic Epilepsy Has Little Effect on Adult Life 30 Years Later: A Population-Based Study. Neurology, 82, 1162-1166. https://doi.org/10.1212/WNL.0000000000000267 |
| [21] | Wickens, S., Bowden, S.C. and D’Souza, W. (2017) Cog-nitive Functioning in Children with Self-Limited Epilepsy with Centrotemporal Spikes: A Systematic Review and Me-ta-Analysis. Epilepsia, 58, 1673-1685. |
| [22] | Teixeira, J.M., Santos, M.E. and Oom, P. (2020) Oral Language in Children with Benign Childhood Epilepsy with Centrotemporal Spikes. Epilepsy & Behavior: E&B, 111, Article ID: 107328.
https://doi.org/10.1016/j.yebeh.2020.107328 |
| [23] | Lima, E.M., Rzezak, P., Montenegro, M.A., Guerreiro, M.M. and Valente, K.D.R. (2020) Social Cognition in Childhood Epilepsy with Centrotemporal Spikes. Seizure, 78, 102-108. https://doi.org/10.1016/j.seizure.2020.03.014 |
| [24] | Wu, L., Yang, X., Zhang, K., Wang, X. and Yang, B. (2021) Impairment of Eye Emotion Discrimination in Benign Childhood Epilepsy with Centrotemporal Spikes: A Neuropsy-chological Study. Brain and Behavior, 11, e02154.
https://doi.org/10.1002/brb3.2154 |
| [25] | Watemberg, N., Afunevitz, S., Ganelin-Cohen, E. and Mahajnah, M. (2018) Clinical Features at the Time of Diagnosis of Benign Epilepsy with Centrotemporal Spikes Do Not Predict Subsequent Seizures. Pediatric Neurology, 88, 36-39.
https://doi.org/10.1016/j.pediatrneurol.2018.08.024 |
| [26] | An, O., Nagae, L.M., Aringazina, A. and Winesett, S.P. (2021) Comparative Assessment of Health-Related Quality of Life with and without Anticonvulsant Therapy in Patients with Childhood Epilepsy with Centrotemporal Spikes. Journal of International Medical Research, 49, No. 8. https://doi.org/10.1177/03000605211039805 |
| [27] | Miranda, M.J. and Ahmad, B.B. (2017) Treatment of Rolandic Epilepsy. LID-V06170482 [pii]. |
| [28] | Glauser, T., Ben-Menachem, E., Fau-Bourgeois, B., et al. (2013) Updated ILAE Evidence Review of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes. Epilepsia, 54, 551-563. |
| [29] | Boon, P.A.-O., Ferrao Santos, S.A.-O., Jansen, A.A.-O., Lagae, L.A.-O., Legros, B.A.-O. and Weckhuysen, S.A.-O. (2021) Recommendations for the Treatment of Epilepsy in Adult and Pedi-atric Patients in Belgium: 2020 Update. Acta Neurologica Belgica, 121, 241-257. |
