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中性粒细胞在哮喘发生发展的作用
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Abstract:
支气管哮喘是一种由多种细胞包括气道的炎性细胞和结构细胞及细胞组分参与的气道慢性炎症性疾病。尽管嗜酸性粒细胞局部浸润以及在疾病中的作用早已被认识，随着研究的发现，中性粒细胞气道中的浸润也在许多研究中得到了证实。虽然中性粒细胞对支气管哮喘发病机制的确切作用尚不清楚，但越来越多的实验证据支持中性粒细胞或中性粒细胞衍生物质，参与了哮喘的发生与发展。在这里，我们回归了中性粒细胞与哮喘相关知识，为中性粒细胞哮喘的进一步研究提供新的方向，为其诊断、治疗提供新的思路和策略。
Bronchial asthma is a chronic inflammatory disease of the airway, which involves a variety of cells, including inflammatory cells and structural cells and cell components of the airway. Although local eosinophil infiltration and its role in disease have long been recognized, infiltration in the neutrophil airways has been confirmed in many studies with the discovery of studies. Although the exact role of neutrophils in the pathogenesis of bronchial asthma is unclear, there is growing experimental evidence to support the involvement of neutrophils, or neutrophil-derived substances involve the occurrence and development of asthma. Here, we return to the knowledge of neutrophils and asthma, provide new directions for further research on neutrophil asthma, and provide new ideas and strategies for its diagnosis and treatment.
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