全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

GINS2与肿瘤相关性研究最新进展
The Latest Progress of GINS2 Correlation with Tumor Research

DOI: 10.12677/ACM.2023.133447, PP. 3144-3149

Keywords: 肿瘤,GINS复合体,GINS2,psf2
Tumor
, GINS Complex, GINS2, psf2

Full-Text   Cite this paper   Add to My Lib

Abstract:

随着我国肿瘤发生率的持续增高,我们需要一个对于肿瘤更加有效的治疗方式和更为敏感的诊断方法,同时我们也要加深了解肿瘤的发生及发展过程,从中发现相关规律并找到予以防治的方法。GINS2又称psf2与psf1,psf3,sld5共同组成GINS复合体的组成部分,并在细胞复制修复及周期调控中发挥着重要作用。近来相关研究表明GISN2与多种肿瘤的预后及发展密切相关,本文就GISN2目前相关研究进展探讨其与肿瘤之间的相关关系。
With the continuous increase of the incidence of tumors in China, we need a more effective treat-ment and more sensitive diagnostic method for tumors. At the same time, we should also deepen the understanding of the occurrence and development process of tumors, and find out the relevant laws and find ways to prevent and cure them. GINS 2, also known as psf 2, together with psf 1, psf 3, slld 5, forms components of the GINS complex and plays an important role in cell replication repair and cycle regulation. Recently, relevant studies have shown that GISN2 is closely related to the prognosis and development of a variety of tumors. In this paper, we explore the relationship be-tween the correlation of GISN2 and tumors.

References

[1]  Huang, H.K., Bailis, J.M., Leverson, J.D., et al. (2005) Suppressors of Bir1p (Survivin) Identify Roles for the Chromo-somal Passenger Protein Pic1p (INCENP) and the Replication Initiation Factor Psf2p in Chromosome Segregation. Mo-lecular and Cellular Biology, 25, 9000-9015.
https://doi.org/10.1128/MCB.25.20.9000-9015.2005
[2]  Choi, J.M., Lim, H., Kim, J.J., et al. (2007) Crystal Structure of the Human GINS Complex. Genes & Development, 21, 1316-1321.
https://doi.org/10.1101/gad.1548107
[3]  Makarova, K.S., Wolf, Y.I., Mekhedov, S.L., et al. (2005) Ancestral Pa-ralogs and Pseudoparalogs and Their Role in the Emergence of the Eukaryotic Cell. Nucleic Acids Research, 33, 4626-4638.
https://doi.org/10.1093/nar/gki775
[4]  Takayama, Y., Kamimura, Y., Okawa, M., et al. (2003) GINS, a Novel Multiprotein Complex Required for Chromosomal DNA Replication in Budding Yeast. Genes & Development, 17, 1153-1165.
https://doi.org/10.1101/gad.1065903
[5]  Kubota, Y., Takase, Y., Komori, Y., et al. (2003) A Novel Ring-Like Complex of Xenopus Proteins Essential for the Initiation of DNA Replication. Genes & Development, 17, 1141-1152.
https://doi.org/10.1101/gad.1070003
[6]  Boskovic, J., Coloma, J., Aparicio, T., et al. (2007) Molecular Architec-ture of the Human GINS Complex. EMBO Reports, 8, 678-684.
https://doi.org/10.1038/sj.embor.7401002
[7]  Chang, Y.P., Wang, G., Bermudez, V., et al. (2007) Crystal Struc-ture of the GINS Complex and Functional Insights into Its Role in DNA Replication. Proceedings of the National Academy of Sciences of the United States of America, 104, 12685-12690.
https://doi.org/10.1073/pnas.0705558104
[8]  Hyrien, O. (2016) How MCM Loading and Spreading Specify Eu-karyotic DNA Replication Initiation Sites. F1000Research, 5.
https://doi.org/10.12688/f1000research.9008.1
[9]  MacNeill, S.A. (2010) Structure and Function of the GINS Complex, a Key Component of the Eukaryotic Replisome. Biochemical Journal, 425, 489-500.
https://doi.org/10.1042/BJ20091531
[10]  De Falco, M., Ferrari, E., De Felice, M., et al. (2007) The Human GINS Complex Binds to and Specifically Stimulates Human DNA Polymerase Alpha-Primase. EMBO Reports, 8, 99-103.
https://doi.org/10.1038/sj.embor.7400870
[11]  Marinsek, N., Barry, E.R., Makarova, K.S., et al. (2006) GINS, a Central Nexus in the Archaeal DNA Replication Fork. EMBO Reports, 7, 539-545.
https://doi.org/10.1038/sj.embor.7400649
[12]  Thomassen, M., Tan, Q. and Kruse, T.A. (2009) Gene Expression Meta-Analysis Identifies Chromosomal Regions and Candidate Genes Involved in Breast Cancer Metastasis. Breast Cancer Research and Treatment, 113, 239-249.
https://doi.org/10.1007/s10549-008-9927-2
[13]  Rantala, J.K., Edgren, H., Lehtinen, L., et al. (2010) Integrative Functional Genomics Analysis of Sustained Polyploidy Phenotypes in Breast Cancer Cells Identifies an Oncogenic Pro-file for GINS2. Neoplasia, 12, 877-888.
https://doi.org/10.1593/neo.10548
[14]  Zheng, M., Zhou, Y., Yang, X., et al. (2014) High GINS2 Transcript Level Predicts Poor Prognosis and Correlates with High Histological Grade and Endocrine Therapy Resistance through Mam-mary Cancer Stem Cells in Breast Cancer Patients. Breast Cancer Research and Treatment, 148, 423-436.
https://doi.org/10.1007/s10549-014-3172-7
[15]  Peng, L., Song, Z., Chen, D., et al. (2016) GINS2 Regulates Ma-trix Metallopeptidase 9 Expression and Cancer Stem Cell Property in Human Triple Negative Breast Cancer. Biomedicine & Pharmacotherapy, 84, 1568-1574.
https://doi.org/10.1016/j.biopha.2016.10.032
[16]  Wei, H.B., Wen, J.Z., Wei, B., et al. (2011) Expression and Clinical Significance of GINS Complex in Colorectal Cancer. Chinese Journal of Gastrointestinal Surgery, 14, 443-447.
[17]  Lee, S.H., Nam, J.K., Park, J.K., et al. (2014) Differential Protein Expression and Novel Biomarkers Re-lated to 5-FU Resistance in a 3D Colorectal Adenocarcinoma Model. Oncology Reports, 32, 1427-1434.
https://doi.org/10.3892/or.2014.3337
[18]  Zhang, X., Zhong, L., Liu, B.Z., et al. (2013) Effect of GINS2 on Pro-liferation and Apoptosis in Leukemic Cell Line. International Journal of Medical Sciences, 10, 1795-1804.
https://doi.org/10.7150/ijms.7025
[19]  Gao, Y., Wang, S., Liu, B. and Zhong, L. (2013) Roles of GINS2 in K562 Human Chronic Myelogenous Leukemia and NB4 Acute Promyelocytic Leukemia Cells. International Journal of Molec-ular Medicine, 31, 1402-1410.
https://doi.org/10.3892/ijmm.2013.1339
[20]  Liu, M., Pan, H., Zhang, F., Zhang, Y., et al. (2013) Identification of TNM Stage-Specific Genes in Lung Adenocarcinoma by Genome-Wide Expression Profiling. Oncology Letters, 6, 763-768.
https://doi.org/10.3892/ol.2013.1469
[21]  Sun, D., Zong, Y., Cheng, J., et al. (2021) GINS2 Attenuates the Development of Lung Cancer by Inhibiting the STAT Signaling Pathway. Journal of Cancer, 12, 99-110.
https://doi.org/10.7150/jca.46744
[22]  Chi, F., Wang, Z., Li, Y. and Chang, N. (2020) Knockdown of GINS2 In-hibits Proliferation and Promotes Apoptosis through the p53/GADD45A Pathway in Non-Small-Cell Lung Cancer. Bio-science Reports, 40, BSR20193949.
https://doi.org/10.1042/BSR20193949
[23]  Huang, L., Chen, S., Fan, H., et al. (2021) GINS2 Promotes EMT in Pancreatic Cancer via Specifically Stimulating ERK/MAPK Signaling. Cancer Gene Therapy, 28, 839-849.
https://doi.org/10.1038/s41417-020-0206-7
[24]  Ye, Y., Song, Y.N., He, S.F., et al. (2019) GINS2 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Thyroid Cancer by Regulating CITED2 and LOXL2. Cancer Gene Therapy, 26, 103-113.
https://doi.org/10.1038/s41417-018-0045-y
[25]  He, S., Zhang, M., Ye, Y., et al. (2021) GINS2 Affects Cell Pro-liferation, Apoptosis, Migration and Invasion in Thyroid Cancer via Regulating MAPK Signaling Pathway. Molecular Medicine Reports, 23, 246.
https://doi.org/10.3892/mmr.2021.11885
[26]  Hao, Y.Q., Liu, K.W., Zhang, X., et al. (2021) GINS2 Was Regu-lated by lncRNA XIST/miR-23a-3p to Mediate Proliferation and Apoptosis in A375 Cells. Molecular and Cellular Bio-chemistry, 476, 1455-1465.
https://doi.org/10.1007/s11010-020-04007-y
[27]  Ma, J., Cai, X., Kang, L., et al. (2021) Identification of Novel Biomarkers and Candidate Small-Molecule Drugs in Cutaneous Melanoma by Comprehensive Gene Microarrays Analy-sis. Journal of Cancer, 12, 1307-1317.
https://doi.org/10.7150/jca.49702
[28]  Tian, Y., Guan, Y., Su, Y., et al. (2021) TRPM2-AS Promotes Bladder Cancer by Targeting miR-22-3p and Regulating GINS2 mRNA Expression. OncoTargets and Therapy, 14, 1219-1237.
https://doi.org/10.2147/OTT.S282151
[29]  Dai, G., Huang, C., Yang, J., et al. (2020) LncRNA SNHG3 Promotes Bladder Cancer Proliferation and Metastasis through miR-515-5p/GINS2 Axis. Journal of Cellular and Molecular Med-icine, 24, 9231-9243.
https://doi.org/10.1111/jcmm.15564
[30]  Feng, H., Zeng, J., Gao, L., et al. (2021) GINS Complex Subunit 2 Facil-itates Gastric Adenocarcinoma Proliferation and Indicates Poor Prognosis. The Tohoku Journal of Experimental Medicine, 255, 111-121.
https://doi.org/10.1620/tjem.255.111
[31]  Yan, T., Liang, W., Jiang, E., et al. (2018) GINS2 Regulates Cell Prolif-eration and Apoptosis in Human Epithelial Ovarian Cancer. Oncology Letters, 16, 2591-2598.
https://doi.org/10.3892/ol.2018.8944
[32]  Ouyang, F., Liu, J., Xia, M., et al. (2017) GINS2 Is a Novel Prognostic Biomarker and Promotes Tumor Progression in Early-Stage Cervical Cancer. Oncology Reports, 37, 2652-2662.
https://doi.org/10.3892/or.2017.5573
[33]  Bu, F., Zhu, X., Yi, X., et al. (2020) Expression Profile of GINS Com-plex Predicts the Prognosis of Pancreatic Cancer Patients. OncoTargets and Therapy, 13, 11433-11444.
https://doi.org/10.2147/OTT.S275649
[34]  Obama, K., Ura, K., Satoh, S., et al. (2005) Up-Regulation of PSF2, a Member of the GINS Multiprotein Complex, in Intrahepatic Cholangiocarcinoma. Oncology Reports, 14, 701-706.
https://doi.org/10.3892/or.14.3.701

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133