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经典Wnt通路与胶质瘤
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Abstract:
脑胶质瘤(glioma)源于胶质细胞的胶质瘤是中枢神经系统最常见的原发性肿瘤。由于中国的胶质瘤患者预后差，死亡率高，在人群中进行有效的胶质瘤筛查和危险因素研究是实现早期诊断和治疗的有效手段。胶质瘤细胞中经典的Wnt通路的异常激活使Wnt/β相关蛋白通路被用作精确治疗胶质瘤的目标。经典的Wnt通路是调控胶质瘤细胞增殖和凋亡的关键通路，也是调控胶质瘤发病机制的重要通路。因此，研究经典的Wnt通路在胶质瘤中的机制对该疾病的诊断、治疗和预后具有重要的临床意义。
Gliomas derived from glial cells are the most common primary tumours of the central nervous system. Due to the poor prognosis and high mortality rate of glioma patients in China, effective glioma screening and risk factor studies in the population are an effective means to achieve early diagnosis and treatment. Aberrant activation of the classical Wnt pathway in glioma cells has led to the use of the Wnt/β-related protein pathway as a target for the precise treatment of gliomas. The classical Wnt pathway is a key pathway in the regulation of glioma cell proliferation and apoptosis, and an important pathway in the regulation of glioma pathogenesis. Therefore, studying the mechanisms of the classical Wnt pathway in glioma has important clinical significance for the diagnosis, treatment and prognosis of this disease.
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