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富血小板血浆联合治疗膝关节骨性关节炎进展
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Abstract:
膝关节骨性关节炎在肌肉骨骼疾病中最为常见，中老年人为好发群体。有症状的患者主诉有疼痛和活动能力障碍。治疗包括物理治疗、口服药物治疗、关节内药物注射治疗、微创介入治疗、手术治疗等。这些疗法旨在控制疼痛和炎症，改善活动能力和功能，而新的基于自体富血小板血浆关节腔注射的疗法有促进骨和软骨再生修复的潜力，成为越来越受到关注的生物产品。因此，本文对富血小板血浆联合治疗方案的临床疗效、优缺点等方面进行综述。
Knee osteoarthritis is the most common in musculoskeletal diseases, middle-aged and elderly people are prone to the group. Symptomatic patients complain of pain and mobility problems. Treatment includes physical therapy, oral drug therapy, intra-articular drug injection therapy, minimally invasive interventional therapy, and surgical therapy. These therapies are designed to control pain and inflammation and improve mobility and function, while new therapies based on autologous platelet-rich plasma injection into the articular cavity have the potential to promote bone and cartilage regeneration and repair, becoming a biological product of increasing interest. Therefore, this paper reviews the clinical efficacy, advantages and disadvantages of combined platelet-rich plasma therapy.
| [1] | Zhao, J.L., Huang, H.T., Liang, G.H., et al. (2020) Effects and Safety of the Combination of Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis. BMC Musculoskeletal Disorders, 21, 224. https://doi.org/10.1186/s12891-020-03262-w |
| [2] | Chen, L., Ye, L., Liu, H., et al. (2020) Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis. BioMed Research International, 2020, Article ID: 1907821.
https://doi.org/10.1155/2020/1907821 |
| [3] | Filippiadis, D., Charalampopoulos, G., Mazioti, A., et al. (2019) In-terventional Radiology Techniques for Pain Reduction and Mobility Improvement in Patients with Knee Osteoarthritis. Diagnostic and Interventional Imaging, 100, 391-400. https://doi.org/10.1016/j.diii.2019.02.011 |
| [4] | Belk, J.W., Kraeutler, M.J., Houck, D.A., et al. (2021) Platelet-Rich Plasma versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The American Journal of Sports Medicine, 49, 249-260. https://doi.org/10.1177/0363546520909397 |
| [5] | Chen, J.X., Dosier, C.R., Park, J.H., et al. (2016) Min-eralization of Three-Dimensional Osteoblast Cultures Is Enhanced by the Interaction of 1α, 25-Dihydroxyvitamin D3 and BMP2 via Two Specific Vitamin D Receptors. Journal of Tissue Engineering and Regenerative Medicine, 10, 40-51. https://doi.org/10.1002/term.1770 |
| [6] | Zhang, H., Li, Z.-L., Yang, F., et al. (2018) Radial Shockwave Treatment Promotes Human Mesenchymal Stem Cell Self-Renewal and Enhances Cartilage Healing. Stem Cell Research & Therapy, 9, 54.
https://doi.org/10.1186/s13287-018-0805-5 |
| [7] | Wang, H.-N., Chen, Y., Cheng, L., et al. (2022) Effect of Low-Load Resistance Training with Different Degrees of Blood Flow Restriction in Patients with Knee Osteoarthritis: Study Protocol for a Randomized Trial. Trials, 23, 6.
https://doi.org/10.1186/s13063-021-05946-7 |
| [8] | Raabe, O., Shell, K., Goessl, A., et al. (2013) Effect of Extra-corporeal Shock Wave on Proliferation and Differentiation of Equine Adipose Tissue-Derived Mesenchymal Stem Cells in Vitro. American Journal of Stem Cell, 2, 62-73. |
| [9] | 管晓军. PRP联合低负荷阻力训练治疗膝关节软骨损伤效果分析[J]. 中国医学创新, 2022, 19(10): 31-34. |
| [10] | Smith, S.M. and Cooper-De Hoff, R.M. (2019) Fixed-Dose Combination Amlodipine/Celecoxib (Consensi) for Hypertension and Osteoarthritis. The American Journal of Medicine, 132, 172-174.
https://doi.org/10.1016/j.amjmed.2018.08.027 |
| [11] | 陶金刚. 富血小板血浆联合塞来昔布治疗膝关节骨性关节炎患者[J]. 临床与病理杂志, 2021, 41(4): 758-763. |
| [12] | 崔瑞开, 李松生, 尤笑迎. 氨基葡萄糖联合关节腔注射自体富血小板血浆治疗膝关节骨性关节炎的临床观察[J]. 河南医学高等专科学校学报, 2022, 34(3): 274-278. |
| [13] | Chiou, C.-S., Wu, C.-M., Dubey, N.K., Lo, W.-C., et al. (2018) Mechanistic Insight into Hyaluronic Acid and Platelet-Rich Plasma-Mediated Anti-Inflammatory and Anti-Apoptotic Activities in Osteoarthritic Mice. Aging (Albany NY), 10, 4152-4165. https://doi.org/10.18632/aging.101713 |
| [14] | 吴九平, 杨利丽, 张郡, 等. 富血小板血浆联合糖皮质激素/局部麻醉药序贯注射治疗关节突关节综合征的疗效观察[J]. 中国疼痛医学杂志, 2020, 26(3): 221-224. |
| [15] | Dernek, B. and Kesiktas, F.N. (2019) Efficacy of Combined Ozone and Platelet-Rich-Plasma Treatment versus Platelet-Rich-Plasma Treatment Alone in Early Stage Knee Osteoarthritis. Journal of Back and Musculoskeletal Rehabilitation, 32, 305-311. https://doi.org/10.3233/BMR-181301 |
| [16] | Bastos, R., Mathias, M. andrade, R., et al. (2018) Intra-Articular Injections of Expanded Mesenchymal Stem Cells with and without Addition of Platelet-Rich Plasma Are Safe and Effective for Knee Osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 26, 3342-3350. https://doi.org/10.1007/s00167-018-4883-9 |
| [17] | 魏双胜, 翁爱英, 张锡链. PRP联合神经阻滞治疗膝骨性关节炎的效果及对炎性因子的影响[J]. 医学理论与实践, 2021(21): 3758-3760. |
| [18] | Cosman, E.R., Dolensky, J.R. and Hoffman, R.A. (2014) Factors That Affect Radiofrequency Heat Lesion Size. Pain Medicine, 15, 2020-2036. https://doi.org/10.1111/pme.12566 |
| [19] | Tian, J.D., Wang, Z.Y., An, J., et al. (2021) Arthroscopic Debridement Combined with Proximal Fibular Osteotomy in Medial Tibial Articular Genu Osteoarthritis Treatment: Systematic Review and Meta-Analysis. Annals of Palliative Medicine, 10, 7894-7904. https://doi.org/10.21037/apm-21-1381 |
| [20] | Alrawashdeh, W., Eschweiler, J., Migliorini, F., et al. (2021) Effec-tiveness of Total Knee Arthroplasty Rehabilitation Programmes: A Systematic Review and Meta-Analysis. Journal of Rehabilitation Medicine, 53, jrm00200.
https://doi.org/10.2340/16501977-2827 |
