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Prevalence of Chronic Kidney Disease and Associated Factors among HIV Patients in the Era of HAART in Ivory Coast: A Cross Sectional, Analytical Study

DOI: 10.4236/ojneph.2023.131004, PP. 20-30

Keywords: HIV, CKD, Prevalence, Africa

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Abstract:

Background: Chronic kidney disease (CKD) may be common among HIV patients living in sub-saharan Africa due to the confluence of CKD risk factors and genetic predisposition. Preventive strategy through early detection and treatment has been advocated for CKD in Africa where majority of patients present late and cannot afford the cost of renal replacement therapy which is not widely available. The purpose of this study was to identify the prevalence and factors associated with CKD among HIV infected adults receiving HAART in a teaching hospital in Ivory Coast. Methods: This is a cross-sectional study of HIV patients on Highly Active Anti Retroviral Therapy followed at the HIV clinic of the medical out-patient department of the University teaching hospital of Bouaké from January to December 2021. CKD was defined as a serum creatinine-based estimated glomerular filtration rate ≤ 60 ml/min/1.73 m2. The collected data was analyzed by using Epi Info 2002 software. Results: Four hundred and two HIV-infected adults 18 years and over were recruited during the study period. We noticed 123 (30.6%) males. The mean age was 40 years. CKD was observed in 42 (10.44) patients infected-HIV. Eighty eight point three percent of patients had CD4 more than 500 cells. Low eGFR correlated with age more than 60 years old, worker in public sector, unemployed, no formal education and HIV type 2. Conclusion: Our study identified a prevalence of CKD of 10.44% by CKD EPI equations among HIV patients on HAART that attended the teaching hospital of Bouaké in Ivory Coast. Early screening and follow up of renal functions is important to minimize the risk of developing end stage kidney disease.

References

[1]  Palella, F.J., Baker, R.K., Moorman, A.C., Chmiel, J.S., Wood, K.C., Brooks, JT. and Holmerg, S.D. (2006) Mortality in the Highly Active Antiretroviral Therapy Era Changing Causes of Death and Disease in the HIV Outpatient Study. Journal of Acquired Immune Deficiency Syndromes, 43, 27-34.
https://doi.org/10.1097/01.qai.0000233310.90484.16
[2]  Adih, W.K., Selix, R.M. and Hu, X. (2011) Trends in Diseases Reported on US Death Certificates That Mentioned HIV Infection, 1996-2006. Journal of the International Association of Providers of AIDS Care, 10, 5-11.
https://doi.org/10.1177/1545109710384505
[3]  Duval, X., Journot, V., Leport, C., et al. (2004) Incidence of and Risk Factors for Adverse Drug Reactions in a Prospective Cohort of HIV-Infected Adults Initiating Protease Inhibitor-Containing Therapy. Clinical Infectious Diseases, 39, 248-255.
https://doi.org/10.1086/422141
[4]  Ekrikpo, U.E., Kengne, A.P., Bello, A.K., Effa, E.E., Noubiap, J.J., Salako, B.L., et al. (2018) Chronic Kidney Disease in the Global Adult HIV-Infected Population: A Systematic Review and Meta-Analysis. PLOS ONE, 13, e0195443.
https://doi.org/10.1371/journal.pone.0195443
[5]  Lucas, G.M., Ross, M.J., Stock, P.G., Shlipak, M.G., Wyatt, C.M., Gupta, S.K., et al. (2014) Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected with HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clinical Infectious Diseases, 59, e96-e138.
https://doi.org/10.1093/cid/ciu617
[6]  Centers for Disease Control and Prevention (1993) 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults. JAMA, 269, 460.
https://doi.org/10.1001/jama.1993.03500040022009
[7]  Zoufaly, A., Cozzi-Lepri, A., Reekie, J., et al. (2014) Immuno-Virological Discordance and the Risk of Non-AIDS and AIDS Events in a Large Observational Cohort of HIV-Patients in Europe. PLOS ONE, 9, e87160.
https://doi.org/10.1371/journal.pone.0087160
[8]  Patrice, H.M., Moussa, O., Francois, K., Yacouba, M., Hugo, M. and Henry, L. (2018) Prevalence and Associated Factors of Chronic Kidney Disease among Patients Infected With Human Immunodeficiency Virus in Cameroon. Iranian Journal of Kidney Diseases, 12, 268-274.
[9]  Emem, C.P., Arogundade, F., Sanusi, A., et al. (2008) Renal Disease in HIV-Seropositive Patients in Nigeria: An Assessment of Prevalence, Clinical Features and Risk Factors. Nephrology Dialysis Transplantation, 23, 741-746.
https://doi.org/10.1093/ndt/gfm836
[10]  Janabi, M.Y., Chale, S., Magao, P., et al. (2002) Renal Abnormalities Associated with Human Immunodeficiency Virus Infection among Police Officers in Dares-Salaam, Tanzania. Proceedings of the XIV International AIDS Conference, Barcelona, 7-12 July 2002.
[11]  Post, F.A., Wyatt, C.M. and Mocroft, A. (2010) Biomarkers of Impaired Renal Function. Current Opinion in HIV and AIDS, 5, 524-530.
https://doi.org/10.1097/COH.0b013e32833f203e
[12]  Juega-Mariño, J., Bonjoch, A., Pérez-Alvarez, N., Negredo, E., Bayes, B., Bonet, J., et al. (2017) Prevalence, Evolution, and Related Risk Factors of Kidney Disease among Spanish HIV-Infected Individuals. Medicine, 96, e7421.
https://doi.org/10.1097/MD.0000000000007421
[13]  Pelchen-Matthews, A., Ryom, L., Borges, á.H., Edwards, S., Duvivier, C., Stephan, C., et al. (2018) Aging and the Evolution of Comorbidities among HIV-Positive Individuals in a European Cohort. AIDS, 2, 2405-2416.
https://doi.org/10.1097/QAD.0000000000001967
[14]  Sempowski, G.D. and Haynes, B.F. (2002) Immune Reconstitution in Patients with HIV Infection. Annual Review of Medicine, 53, 269-284.
https://doi.org/10.1146/annurev.med.53.082901.104032
[15]  Santiago, P., Grinsztejn, B., Friedman, R.K., Cunha, C.B., Coelho, L.E., Luz, P.M., et al. (2014) Screening for Decreased Glomerular Filtration Rate and Associated Risk Factors in a Cohort of HIV-Infected Patients in a Middle-Income Country. PLOS ONE, 9, e93748.
https://doi.org/10.1371/journal.pone.0093748
[16]  Menéndez-Arias, L. and Álvarez, M. (2014) Antiretroviral Herapy and Drug Resistance in Human Immunodeficiency Virus Type 2 Infection. Antiviral Research, 102, 70-86.
https://doi.org/10.1016/j.antiviral.2013.12.001
[17]  Heron, J.E., Bagnis, C.I. and Gracey, D.M. (2020) Contemporary Issues and New Challenges in Chronic Kidney Disease amongst People Living with HIV. AIDS Research and Therapy, 17, 11-24.
https://doi.org/10.1186/s12981-020-00266-3

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