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2002~2022年我国宫颈癌研究进展及其可视化分析
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Abstract:
宫颈癌是严重威胁女性健康的一种常见恶性肿瘤,对宫颈癌病理机制的深入了解及其潜在治疗方案的积极探索,有望为宫颈癌的预防和治疗带来有效的干预策略。本文借助科学文献可视化软件Citespace和CNKI数据库,对我国宫颈癌的研究现状、研究热点及发展趋势等进行综合全面的汇总。以宫颈癌作为关键词,检索到2002~2022年所收录的27,964篇期刊论文。分析显示,宫颈癌研究领域的发文量在2002~2019年间呈现一个逐年增长趋势,提示这段时间宫颈癌研究获得越来越多关注。然而2019年之后发文量有所下降,研究热点也逐渐从患病之后的疾病治疗转为患病前的预防筛查为主。我国对宫颈癌的研究模式主要是以高校附属医院为主,高校研究为辅,相应的发文作者也主要是医院和高校的相关科研人员,研究内容和方向与社会需求、技术发展等契合良好。本文有助于相关科研人员了解宫颈癌领域的研究现状,把控宫颈癌研究热点变化,并为其制定相关科研方案提供一定的理论参考。
Cervical cancer is one of common malignant cancers imposing a great threat to woman health. A better understanding the pathogenesis of cervical cancer and exploring potential therapeutic strategies will benefit for efficient prevention and treatment of cervical cancer. Taking advantage of scientific literature visualization software Citespace and the CNKI database, here we comprehensively summarized the progress, hotspots and trends of cervical cancer research in China. We retrieved 27,964 literatures from 2002 to 2022 with cervical cancer as the keyword. Analysis of these literatures showed that the number of literatures published in the field of cervical cancer exhibited an annually increasing trend during 2002~2019, indicating cervical cancer had attracted more and more attentions. However, the number of literatures began to decline since 2019, and the research hotspot was switched from post-diagnostic treatment to pre-diagnostic prevention and screening. In China, the research mode of cervical cancer is mainly based on university affiliated hospitals, supplemented with university research. Accordingly, the authors are mainly related researchers from hospitals and universities. The research interests and directions are well in line with the needs of society and the development of techniques. Overall, this study will be helpful for understanding current progress of cervical cancer and research hotspots, and conceiving proposal of relative scientific research.
[1] | Johnson, C.A., James, D., Marzan, A., et al. (2019) Cervical Cancer: An Overview of Pathophysiology and Management. Seminars in Oncology Nursing, 35, 166-174. https://doi.org/10.1016/j.soncn.2019.02.003 |
[2] | Burd, E.M. (2003) Human Papillomavirus and Cervical Cancer. Clinical Microbiology Reviews, 16, 1-17.
https://doi.org/10.1128/CMR.16.1.1-17.2003 |
[3] | Schiffman, M., Castle, P.E., Jeronimo, J., et al. (2007) Human Papillomavirus and Cervical Cancer. The Lancet (London, England), 370, 890-907. https://doi.org/10.1016/S0140-6736(07)61416-0 |
[4] | Pal, A. and Kundu, R. (2019) Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy. Frontiers in Microbiology, 10, 3116. https://doi.org/10.3389/fmicb.2019.03116 |
[5] | Yang, A., Farmer, E., Wu, T.C., et al. (2016) Perspectives for Therapeutic HPV Vaccine Development. Journal of Biomedical Science, 23, 75. https://doi.org/10.1186/s12929-016-0293-9 |
[6] | Yuan, Y., Cai, X., Shen, F., et al. (2021) HPV Post-Infection Microenvironment and Cervical Cancer. Cancer Letters, 497, 243-254. https://doi.org/10.1016/j.canlet.2020.10.034 |
[7] | Rosalik, K., Tarney, C. and Han, J. (2021) Human Papilloma Virus Vaccination. Viruses, 13, 1091.
https://doi.org/10.3390/v13061091 |
[8] | Wang, R., Pan, W., Jin, L., et al. (2020) Human Papillomavirus Vaccine against Cervical Cancer: Opportunity and Challenge. Cancer Letters, 471, 88-102. https://doi.org/10.1016/j.canlet.2019.11.039 |
[9] | 周琦, 吴小华, 刘继红, 等. 宫颈癌诊断与治疗指南(第四版) [J]. 中国实用妇科与产科杂志, 2018, 34(6): 613-622.
http://doi.org/10.19538/j.fk2018060111 |
[10] | 陈悦, 李娜, 胡元晶. 早期宫颈癌宫颈广泛性切除术的研究进展[J]. 国际妇产科学杂志, 2022, 49(5): 524-528. |
[11] | 邵巧云, 王文凤, 董国锋, 等. 早期宫颈癌患者术后盆腔淋巴囊肿形成的因素分析[J]. 实用癌症杂志, 2022, 37(11): 1859-1862. |
[12] | 赵方辉, 戎寿德, 乔友林. 宫颈癌及其癌前病变筛查方法现状[J]. 中国医学科学院学报, 2001(6): 638-641. |
[13] | 师雅琳. 子宫颈上皮内病变组织中免疫组化与TCT对宫颈癌的预测应用[J]. 中国校医, 2021, 35(10): 750-752. |
[14] | 钱德英. 阴道镜在宫颈癌诊断中的应用[J]. 中国实用妇科与产科杂志, 2003(3): 12-14. |
[15] | 余辉, 傅海鹦, 全培青. 宫颈原位癌围手术期个性化护理的应用价值[J]. 中国肿瘤临床与康复, 2020, 27(5): 632-635. http://doi.org/10.13455/j.cnki.cjcor.2020.05.32 |
[16] | 郑玥. 宫颈微小浸润癌的诊断和治疗[D]: [博士学位论文]. 北京: 北京协和医学院, 2019. |
[17] | 章文华, 李楠, 吴令英. 重视宫颈癌患者年轻化的趋势[J]. 浙江肿瘤, 2000(2): 112-114. |
[18] | 陈秀杰, 王嫱, 王雅楠, 等. 宫颈HPV感染状况及其与宫颈柱状上皮异位的相关性研究[J]. 国际妇产科学杂志, 2021, 48(6): 710-714. |
[19] | 李敏. 不同年龄宫颈癌患者临床病理特征分析[J]. 医学理论与实践, 2022, 35(1): 85-86.
http://doi.org/10.19381/j.issn.1001-7585.2022.01.035 |
[20] | 陈晓雯, 姜李媛, 陈亚, 等. 2015-2019年杭州地区农村妇女宫颈癌筛查情况分析[J]. 中国妇幼保健, 2022, 37(23): 4460-4463. http://doi.org/10.19829/j.zgfybj.issn.1001-4411.2022.23.034 |
[21] | 程明艳, 姜浩, 孙亚男, 等. HR-HPV基因联合TV-CDFI在宫颈癌筛查及诊断中的应用[J]. 影像科学与光化学, 2022, 40(6): 1481-14815. |