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AECOPD患者并发肺栓塞的生物学标志物研究进展
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Abstract:
慢性阻塞性肺疾病急性加重(AECOPD)是肺栓塞(PE)的独立危险因素，同时，PE也是AECOPD患者预后不良的重要因素，AECOPD合并PE导致患者住院时间延长和病死率增加。由于AECOPD与PE的临床表现极为相似，极易造成AECOPD合并PE的漏诊及误诊。目前，CT肺动脉造影是确诊AECOPD合并PE的金标准，但由于无法覆盖基层医院及危重患者，因此，临床工作中仍迫切需要开展低风险、便捷的筛查手段。本文将对AECOPD合并PE患者生物学标志物的研究进展进行综述。
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an independent risk fac-tor for pulmonary embolism (PE), and PE is also an important factor in the poor prognosis of pa-tients with AECOPD, and AECOPD combined with PE leads to longer hospital stay and increased case fatality. Because the clinical manifestations of AECOPD and PE are very similar, it is easy to cause missed diagnosis and misdiagnosis of AECOPD combined with PE. At present, CT pulmonary angi-ography is the gold standard for the diagnosis of AECOPD and PE, but because it cannot cover pri-mary hospitals and critically ill patients, there is still an urgent need for low-risk and convenient screening methods in clinical work. This article will review the research progress of biological markers in patients with AECOPD and PE.
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