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微小RNA通过靶向PI3K/AKT信号通路改善2型糖尿病胰岛素抵抗的机制研究
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Abstract:
胰岛素抵抗(Insulin resistance, IR)是2型糖尿病(type 2 diabetes mellitus, T2DM)的主要发病机制，IR产生机制尤为复杂，胰岛素信号通路的转导在其中扮演着重要角色。近年来，越来越多有关微小RNA (miRNA)的研究证实，miRNA是糖脂代谢的关键调节因子，可能与其调控信号通路有关。而PI3K/Akt在胰岛素信号通路中居于主导地位，因此，探索miRNA与PI3K/Akt信号通路之间的调控关系，明确其作用靶点及调控方向，有利于为T2DM提供新的治疗方向，miRNA有望成为T2DM的诊断和治疗新靶点。
Insulin resistance (IR) is the main pathogenesis of type 2 diabetes mellitus (T2DM), and the gener-ation mechanism of IR is particularly complex, in which insulin signaling pathway transduction plays an important role. In recent years, more and more studies on MicroRNAs (miRNAs) have con-firmed that miRNAs are key regulatory factors in glycolipid metabolism and may be related to their regulatory signaling pathways. PI3K/Akt plays a dominant role in insulin signaling pathway. Therefore, exploring the regulatory relationship between miRNA and PI3K/Akt signaling pathway as well as clarifying its target and direction of regulation is conducive to providing new therapeutic directions for T2DM, and miRNA is expected to become a new target for diagnosis and treatment of T2DM.
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