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血清尿酸在心血管疾病中的研究进展
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Abstract:
尿酸是人体嘌呤代谢的终产物。国内外研究表明尿酸不仅是痛风的原因，而且可能在心血管疾病的发生中发挥作用。几项临床研究已报告血清尿酸可作为心血管结局的预测标志物。尽管高尿酸血症与心血管疾病的因果关系仍存在争议，但由于全球高尿酸血症患病率的增加，人们对尿酸的兴趣越来越大。本文就UA与心血管疾病的发病机制及ULT治疗心血管疾病的疗效作一综述。
Uric acid is an end product of purine metabolism in humans. Domestic and foreign studies have shown that uric acid is not only the cause of gout, but also may play a role in the development of cardiovascular diseases. Several clinical studies have reported that serum uric acid can serve as a predictive marker of cardiovascular outcome. Although the causal relationship between hyperu-ricemia and cardiovascular disease remains controversial, the interest in uric acid is increasing due to the increased prevalence of hyperuricemia worldwide. This paper summarizes the pathogenesis of UA and the efficacy of ULT in the treatment of cardiovascular diseases.
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