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低温、低氧对肥胖的影响及机制研究进展
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Abstract:
肥胖是由遗传和环境等因素共同作用而导致的慢性代谢性疾病，是21世纪最具挑战性的公共卫生问题之一。全球的肥胖患病率呈明显的上升趋势，根据最新的流行病学调查显示，肥胖的患病率存在显著的地理差异，高海拔地区的肥胖患病率明显低于平原地区。很少有人研究高原环境暴露对肥胖的影响，最近有人提出了低温、低氧等因素作为一种新型减肥策略，学者们对其研究还处于初步探究阶段，尚未完全阐明。本文检索了当前的相关文献，总结了低温、低氧等因素对肥胖的影响及机制相关最新研究，支持低温、低氧因素可能是调节肥胖的观点。
Obesity is a chronic metabolic disease caused by genetic and environmental factors. It is one of the most challenging public health problems in the 21st century. The prevalence of obesity in the world shows an obvious upward trend. According to the latest epidemiological survey, there are signifi-cant geographical differences in the prevalence of obesity. The prevalence of obesity in high-altitude areas is significantly lower than that in plain areas. Few people have studied the impact of high al-titude environmental exposure on obesity. Recently, some people have proposed low temperature, hypoxia and other factors as a new weight loss strategy. Scholars’ research on it is still in the pre-liminary exploration stage, and has not been fully clarified. This paper searched the current rele-vant literature, summarized the latest research on the effects and mechanisms of hypothermia, hy-poxia and other factors on obesity, and supported the view that hypothermia, hypoxia and other factors may regulate obesity.
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