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肠道微生物与骨骼健康
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Abstract:
肠道菌群是人体最大的生态系统，是居住在机体肠道内的一群共生细菌、真菌、病毒的总称。大量的研究已经证实，其在调控人体重要的生理过程和众多复杂疾病的机制中发挥着关键作用。本文将结合近年来的研究进展及热点，综述肠道菌群调控骨代谢的各种潜在机制，通过阐述肠道菌群对各种生物学过程的调节作用，包括营养吸收和肠粘膜屏障、免疫系统功能、激素环境和代谢产物，来全面总结肠道微生物群和骨代谢之间的关系，本文还将综述以肠道菌群为目标，维持骨骼稳态，预防和治疗骨质疏松症的新思路和靶点。
Gut microbiota is the largest ecosystem of the human body consisting of bacteria, fungi, and viruses that colonize human intestine. Numerous studies have confirmed that gut microbiota plays a key role in the regulation of a wide variety of biological processes and the pathogenic mechanism of many complex diseases. In this review, we summarize various potential mechanisms of gut micro-biota about how to affect bone metabolism including nutrients absorption, intestinal mucosal bar-rier, immune system, hormone and gut microbial excretion by products. This paper also describes those microbiota important for the regulation of bone metabolism may serve as novel therapeutic targets to maintaining bone homeostasis, preventing and treating osteoporosis.
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