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急性主动脉夹层生物诊断标志物的研究进展
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Abstract:
急性主动脉夹层是严重心血管急症，具有较高的发病率和死亡率，然而临床表现的主要症状是胸背痛，因此难与其他突发的严重胸背痛疾病鉴别，而生存率与及时诊断和精准的管理直接相关，目前对该病的诊断主要依赖于各种成像技术，相对耗时且有诸多局限性。生物标志物的应用为新的诊断技术提供了新方向，现已发现多种主动脉夹层诊断潜在的标志物，本文根据国内外相关研究对主动脉夹层生物学诊断标志物的应用及进展进行综述。
Acute aortic dissection is a serious cardiovascular emergency with a high incidence rate and mor-tality. However, the main symptom of clinical manifestation is chest and back pain, so it is difficult to distinguish it from other sudden severe chest and back pain diseases. The survival rate is directly related to timely diagnosis and accurate management. At present, the diagnosis of this disease mainly depends on various imaging technologies, which is relatively time-consuming and has many limitations. The application of biomarkers provides a new direction for new diagnostic techniques. A variety of potential biomarkers have been found for the diagnosis of aortic dissection. This article reviews the application and progress of biomarkers for the diagnosis of aortic dissection based on relevant research at home and abroad.
| [1] | 中国医师协会心血管外科分会大血管外科专业委员会. 主动脉夹层诊断与治疗规范中国专家共识[J]. 中华胸心血管外科杂志, 2017, 33(11): 641-654. |
| [2] | 成泽怡, 杨梦阳, 李雅茹, 等. 主动脉夹层生物标志物的研究进展[J]. 心血管病学进展, 2019, 40(1): 49-53. |
| [3] | Erbel, R., Aboyans, V., Boileau, C., et al. (2014) 2014 ESC Guidelines on the Diagnosis and Treatment of Aortic Diseases: Document Covering Acute and Chronic Aortic Diseases of the Thoracic and Abdominal Aorta of the Adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). European Heart Journal, 35, 2873-2926. https://doi.org/10.1093/eurheartj/ehu281 |
| [4] | Wang, H., Yang, H., Tang, Q., et al. (2020) Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics. BioMed Research Inter-national, 2020, Article ID: 7806409.
https://doi.org/10.1155/2020/7806409 |
| [5] | Deng, T., Liu, Y., Gael, A., et al. (2022) Study on Proteomics-Based Aortic Dissection Molecular Markers Using iTRAQ Combined with Label Free Techniques. Frontiers in Physiology, 13, Article ID: 862732.
https://doi.org/10.3389/fphys.2022.862732 |
| [6] | 岳增旭, 孔一慧. 主动脉夹层及其相关循环生物标志物[J]. 心血管病学进展, 2019, 40(4): 595-598. |
| [7] | Lu, P., Feng, X., Li, R., et al. (2022) A Novel Serum Biomarker Model to Discriminate Aortic Dissection from Coronary Artery Disease. Disease Markers, 2022, Article ID: 9716424. https://doi.org/10.1155/2022/9716424 |
| [8] | 谢品超, 付裕, 杨友信, 等. D-二聚体联合CT血管造影诊断主动脉夹层临床研究[J]. 中国CT和MRI杂志, 2021, 19(12): 75-77. |
| [9] | Long, D., Keim, S., April, M., et al. (2021) Can D-Dimer in Low-Risk Patients Exclude Aortic Dissection in the Emergency Department? The Journal of Emergency Medicine, 61, 627-634.
https://doi.org/10.1016/j.jemermed.2021.07.028 |
| [10] | Neilson, K.A., Ali, N.A., Muralidharan, S., et al. (2011) Less Label, More Free: Approaches in Label-Free Quantitative Mass Spectrometry. Proteomics, 11, 535-553. https://doi.org/10.1002/pmic.201000553 |
| [11] | Yang, S., Xiao, Y., Du, Y., et al. (2021) Diagnostic and Prognostic Value of Neutrophil Extracellular Trap Levels in Patients with Acute Aortic Dissection. Frontiers in Cardiovascular Medicine, 8, Article ID: 683445.
https://doi.org/10.3389/fcvm.2021.683445 |
| [12] | Zhou, X., Wang, R., Zhang, T., et al. (2019) Identification of Lysophosphatidylcholines and Sphingolipids as Potential Biomarkers for Acute Aortic Dissection via Serum Metabo-lomics. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, 57, 434-441.
https://doi.org/10.1016/j.ejvs.2018.07.004 |
| [13] | Pan, X., Zhou, Y., Yang, G., et al. (2021) Lysophosphatidic Acid May Be a Novel Biomarker for Early Acute Aortic Dissection. Frontiers in Surgery, 8, Article ID: 789992. https://doi.org/10.3389/fsurg.2021.789992 |
| [14] | Shi, Q., Meng, F., Yue, J., et al. (2021) Diagnostic Value of Se-rum Amyloid A and C-Reactive Protein for Predicting Acute Aortic Dissection. Chinese Medical Journal, 101, 1275-1281. |
| [15] | Zeng, T., Gan, J., Liu, Y., et al. (2020) ADAMTS-5 Decreases in Aortas and Plasma from Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis. Frontiers in Cardiovascular Medicine, 7, 136.
https://doi.org/10.3389/fcvm.2020.00136 |
| [16] | Takagi, H., Hari, Y., Nakashima, K., et al. (2020) Matrix Metallo-proteinases and Acute Aortic Dissection: Et Tu, Brute? Interactive Cardiovascular and Thoracic Surgery, 30, 465-476. https://doi.org/10.1093/icvts/ivz286 |
| [17] | Zeng, T., Yuan, J., Gan, J., et al. (2019) Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients with Acute Aortic Dissection. The Canadian Journal of Cardiology, 35, 42-50. https://doi.org/10.1016/j.cjca.2018.11.008 |
| [18] | Zhang, N., Wang, Y., Hu, H., et al. (2022) Assessing Serum Levels of SM22α as a New Biomarker for Patients with Aortic Aneurysm/Dissection. PLOS ONE, 17, e0264942. https://doi.org/10.1371/journal.pone.0264942 |
| [19] | 王萌萌, 王宝珠, 迪拉热？阿迪, 等. 急性主动脉夹层患者组织相关生物标志物的探讨[J]. 中华心血管病杂志, 2021, 49(11): 1108-1116. |
| [20] | Zeng, Q., Rong, Y., Li, D., et al. (2020) Identification of Serum Biomarker in Acute Aortic Dissection by Global and Targeted Metabolomics. Annals of Vascular Surgery, 68, 497-504. https://doi.org/10.1016/j.avsg.2020.06.026 |
| [21] | 魏华, 倪企春, 陈静, 等. 血清脂联素和分泌型卷曲蛋白5水平与冠状动脉支架植入术后再狭窄的相关性分析[J]. 中华实用诊断与治疗杂志, 2020, 34(8): 818-821. |
| [22] | 张利敏, 游婕, 朱陈华, 等. 脂联素和D-二聚体在急性主动脉夹层中的诊断价值[J]. 医学信息, 2022, 35(14): 62-65. |
| [23] | Huang, H., Ye, G., Lai, S., et al. (2021) Plasma Lipidomics Identifies Unique Li-pid Signatures and Potential Biomarkers for Patients with Aortic Dissection. Frontiers in Cardiovascular Medicine, 8, Article ID: 757022.
https://doi.org/10.3389/fcvm.2021.757022 |
| [24] | Autieri, M.V. (2018) IL-19 and Other IL-20 Family Member Cy-tokines in Vascular Inflammatory Diseases. Frontiers in Immunology, 9, 700. https://doi.org/10.3389/fimmu.2018.00700 |
| [25] | Zhang, J., Liu, J., Zhao, M., et al. (2020) The Expression of Inter-leukin 20 Increases in Plasma and Aortic Tissues from Patients with Acute Aortic Dissection. Clinica Chimica Acta; In-ternational Journal of Clinical Chemistry, 510, 373-380.
https://doi.org/10.1016/j.cca.2020.07.049 |
| [26] | Hu, H., Zhang, G., Hu, H., et al. (2019) Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection. Mediators of Inflammation, 2019, Article ID: 8691294. https://doi.org/10.1155/2019/8691294 |
| [27] | Zhang, H., Guo, J., Zhang, Q., et al. (2021) The Potential Value of the Neutrophil to Lymphocyte Ratio for Early Differential Diagnosis and Prognosis Assessment in Patients with Aortic Dissection. Clinical Biochemistry, 97, 41-47.
https://doi.org/10.1016/j.clinbiochem.2021.08.002 |
