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探讨坏死性凋亡相关长链非编码RNA作为肝癌预后预测标志物的价值
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Abstract:
目的：肝细胞癌(Hepatocellular carcinoma, HCC)是一种常见的恶性肿瘤。凋亡是诱导肿瘤发生发展的重要因素，而坏死性凋亡是程序性死亡的一种形式，亦是肿瘤细胞的一个重要特征。但是与坏死性凋亡相关的长链非编码RNA的价值仍未得到研究。通过肝癌转录组表达数据分析与肝癌坏死性凋亡相关的lncRNA，并评估其在肝癌研究的意义。根据获取癌症基因组图谱(TCGA)数据库的转录组表达数据，确定与坏死性凋亡相关的lncRNA并构建肝癌预后生存风险模型。分析显示坏死性凋亡评分可作为肝癌患者新的独立指标。基因集富集(GSEA)分析显示，坏死性凋亡风险评分反映了与细胞多糖降解和脂肪酸代谢过程有很高的相关性。综上所述，表明与坏死性凋亡相关的lncRNA在肝癌诊疗中的重要作用，并可能在未来作为肝癌患者预后预测的候选指标。
Hepatocellular carcinoma (HCC) is a common malignant tumor. Apoptosis is an important factor in-ducing tumor development, and necroptosis is a form of programmed death and an important fea-ture of tumor cells. But the value of long non-coding RNAs associated with necroptosis is still not obtained Study. lncRNAs associated with necroptosis in HCC were analyzed by hepatoma transcrip-tome expression data and their significance in HCC research was assessed. According to the tran-scriptome expression data obtained from the Cancer Genome Atlas (TCGA) database, lncRNAs asso-ciated with necroptosis were identified and a prognostic survival risk model for liver cancer was constructed. The analysis showed that the necroptosis score could be used as a new independent indicator in patients with liver cancer. Gene set enrichment (GSEA) analysis showed that the necroptosis risk score reflected a high correlation with cellular polysaccharide degradation and fatty acid metabolism processes. In summary, it is shown that lncRNAs associated with necroptosis play an important role in the diagnosis and treatment of liver cancer and may be used as candidate markers for prognosis prediction in patients with liver cancer in the future.
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