|
子宫腺肌病临床研究进展
|
Abstract:
子宫腺肌病(Adenomyosis, AM)是指在子宫肌层中存在子宫内膜组织,并伴有不等程度的肌层平滑肌细胞肥大和增生。AM是一种常见且难治的妇科良性肿瘤性疾病,是导致育龄期女性及围绝经期女性子宫全切的主要原因之一。近年来,生育力保护的理念得到了人们的认可。女性越来越关注子宫的生殖健康,要求子宫腺肌病的治疗长效化。然而,目前AM的发病机制尚不明确。
Adenomyosis (AM) refers to the presence of endometrial tissue in the myometrium, accompanied by varying degrees of hypertrophy and proliferation of myometrial smooth muscle cells. AM is a common and refractory gynecological benign tumor disease, which is one of the main reasons for total hysterectomy in women of childbearing age and perimenopause. In recent years, the concept of fertility protection has been recognized by people. Women pay more and more attention to the reproductive health of the uterus and require long-term treatment of adenomyosis. However, the pathogenesis of AM is still unclear.
[1] | Zannoni, L., Ambrosio, M., Raimondo, D., et al. (2020) Question Mark Sign and Transvaginal Ultrasound Uterine Ten-derness for the Diagnosis of Adenomyosis: A Prospective Validation. Journal of Ultrasound in Medicine, 39, 1405-1412. https://doi.org/10.1002/jum.15237 |
[2] | Harada, T., Khine, Y.M., Kaponis, A., et al. (2016) The Impact of Adeno-myosis on Women’s Fertility. Obstetrical & Gynecological Survey, 71, 557-568. https://doi.org/10.1097/OGX.0000000000000346 |
[3] | Vannuccini, S. and Petraglia, F. (2019) Recent Advances in Understanding and Managing Adenomyosis. F1000Research, 8, 283. https://doi.org/10.12688/f1000research.17242.1 |
[4] | Raffone, A., Seracchioli, R., Raimondo, D., et al. (2021) Prevalence of Adenomyosis in Endometrial Cancer Patients: A Systematic Review and Meta-Analysis. Archives of Gy-necology and Obstetrics, 303, 47-53.
https://doi.org/10.1007/s00404-020-05840-8 |
[5] | Anna, S.C., Jacques, D. and Madeleine, D.M. (2021) Conserva-tive Management of Uterine Adenomyosis: Medical vs. Surgical Approach. Journal of Clinical Medicine, 10, 4878-4878. https://doi.org/10.3390/jcm10214878 |
[6] | Upson, K. and Missmer, S.A. (2020) Epidemiology of Adenomyosis. Seminars in Reproductive Medicine, 38, 89-107.
https://doi.org/10.1055/s-0040-1718920 |
[7] | Li, N., Yuan, M., Li, Q., et al. (2022) Higher Risk of Anxiety and Depression in Women with Adenomyosis as Compared with Those with Uterine Leiomyoma. Journal of Clinical Medi-cine, 11, 2638.
https://doi.org/10.3390/jcm11092638 |
[8] | Zhang, H.Y., Wang, A.Q., Zhu, S., et al. (2022) Changes of Coagula-tion Function in Patients with Adenomyosis. Chinese Journal of Obstetrics and Gynecology, 57, 179-189. |
[9] | Indrielle-Kelly, T., Frühauf, F., Burgetová, A., et al. (2019) Diagnosis of Endometriosis 2nd Part—Ultrasound Diagnosis of Endometriosis (Adenomyosis, Endometriomas, Adhesions) in the Community. Czech Gynaecology, 84, 260-268. |
[10] | Brosens, I., Pijnenborg, R. and Benagiano, G. (2013) Defective Myometrial Spiral Ar-tery Remodelling as a Cause of Major Obstetrical Syndromes in Endometriosis and Adenomyosis. Placenta, 34, 100-105.
https://doi.org/10.1016/j.placenta.2012.11.017 |
[11] | García-Solares, J., et al. (2018) Pathogenesis of Uterine Ade-nomyosis: Invagination or Metaplasia? Fertility and Sterility, 109, 371-379. https://doi.org/10.1016/j.fertnstert.2017.12.030 |
[12] | Hiraoka, T., Hirota, Y., Aikawa, S., et al. (2022) Constant Ac-tivation of STAT3 Contributes to the Development of Adenomyosis in Females. Endocrinology, 163, bqac044. https://doi.org/10.1210/endocr/bqac044 |
[13] | Zhai, J., Vannuccini, S., Petraglia, F. and Giudice, L.C. (2020) Ade-nomyosis: Mechanisms and Pathogenesis. Seminars in Reproductive Medicine, 38, 129-143. https://doi.org/10.1055/s-0040-1716687 |
[14] | Guo, S.W. (2020) The Pathogenesis of Adenomyosis vis-a-vis En-dometriosis. Journal of Clinical Medicine, 9, 485.
https://doi.org/10.3390/jcm9020485 |
[15] | 黎霓, 王国云. 子宫腺肌病发病机制的研究现状[J]. 中国实用妇科与产科杂志, 2019, 35(5): 493-498. |
[16] | Meredith, S.M., Sanchez-Ramos, L. and Kaunitz, A.M. (2009) Diagnostic Accuracy of Transvaginal Sonography for the Diagnosis of Adenomyosis: Systematic Review and Metaanalysis. The American Journal of Obstetrics and Gynecology, 201, 107.e1-107.e 6. https://doi.org/10.1016/j.ajog.2009.03.021 |
[17] | Caridi, T.M., De la Garza-Ramos, C., Brook, O.R., et al. (2022) Uterine Artery Embolization for Symptomatic Adenomyosis: Proceedings from a Society of Interventional Radiology Foundation Research Consensus Panel. Journal of Vascular and Interventional Radiology, 33, 586-592. https://doi.org/10.1016/j.jvir.2022.01.017 |
[18] | Bazot, M. and Darai, E. (2018) Role of Transvaginal Sonography and Magnetic Resonance Imaging in the Diagnosis of Uterine Adenomyosis. Fertility and Sterility, 109, 389-397. https://doi.org/10.1016/j.fertnstert.2018.01.024 |
[19] | Reinhold, C., McCarthy, S., Bret, P.M., et al. (1996) Diffuse Adenomyosis: Comparison of Endovaginal US and MR Imaging with Histopathologic Correlation. Radiology, 199, 151-158. https://doi.org/10.1148/radiology.199.1.8633139 |
[20] | 尹强, 费凡, 靳金岩, 曹艳婷. 子宫腺肌病和子宫肌瘤鉴别诊断中MRI检查的应用与效果评估[J]. 实用妇科内分泌电子杂志, 2021, 8(13): 138-140. |
[21] | 薛建秀. 子宫腺肌病MRI表现及诊断价值分析[J]. 影像研究与医学应用, 2020, 4(16): 181-182. |
[22] | van der Kooij, S.M., Hehenkamp, W.J.K., Birnie, E., et al. (2013) The Effect of Treatment Preference and Treatment Allocation on Patients’ Health-Related Quality of Life in the Randomized EMMY Trial. The European Journal of Obstetrics & Gynecology and Reproductive Biology, 169, 69-74. https://doi.org/10.1016/j.ejogrb.2013.01.019 |
[23] | Streuli, I., Dubuisson, J., Santulli, P., et al. (2014) An Update on the Pharmacological Management of Adenomyosis. Expert Opinion on Pharma-cotherapy, 15, 2347-2360. https://doi.org/10.1517/14656566.2014.953055 |
[24] | 杨丽, 肖雁冰, 韩磊. 以保留子宫为目标的子宫腺肌病治疗研究进展[J]. 局解手术学杂志, 2020, 29(12): 1019-1023. |
[25] | Abbott, J.A. (2017) Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, Diagnosis, and Management. Best Practice & Research Clinical Obstetrics & Gynaecology, 40, 68-81.
https://doi.org/10.1016/j.bpobgyn.2016.09.006 |
[26] | Dessouky, R., Gamil, S.A., Nada, M.G., Mousa, R. and Libda, Y. (2019) Management of Uterine Adenomyosis: Current Trends and Uterine Artery Embolization as a Potential Alterna-tive to Hysterectomy. Insights Imaging, 10, 48.
https://doi.org/10.1186/s13244-019-0732-8 |
[27] | Chapron, C., Vannuccini, S., Santulli, P., et al. (2020) Diagnosing Adenomyosis: An Integrated Clinical and Imaging Approach. Human Reproduction Update, 26, 392-411. https://doi.org/10.1093/humupd/dmz049 |
[28] | Grimbizis, G.F., Mikos, T. and Tarlatzis, B. (2014) Uterus-Sparing Operative Treatment for Adenomyosis. Fertility and Sterility, 101, 472-487. https://doi.org/10.1016/j.fertnstert.2013.10.025 |
[29] | Osada, H. (2018) Uterine Adenomyosis and Adenomyoma: The Surgical Approach. Fertility and Sterility, 109, 406-417. https://doi.org/10.1016/j.fertnstert.2018.01.032 |
[30] | Liu, X., Ding, D., Ren, Y. and Guo, S.W. (2018) Transvaginal Elastosonography as an Imaging Technique for Diagnosing Adenomyosis. Reproductive Sciences, 25, 498-514. https://doi.org/10.1177/1933719117750752 |
[31] | Squillace, A.L.A., Simonian, D.S., Allegro, M.C., et al. (2021) Adenomyosis and in Vitro Fertilization Impacts—A Literature Review. Jornal Brasileiro de Reproducao Assistida, 25, 303-309.
https://doi.org/10.5935/1518-0557.20200104 |
[32] | Vannuccini, S., Luisi, S., Tosti, C., et al. (2018) Role of Medical Therapy in the Management of Uterine Adenomyosis. Fertility and Sterility, 109, 398-405. https://doi.org/10.1016/j.fertnstert.2018.01.013 |
[33] | Pontis, A., D’Alterio, M.N., Pirarba, S., et al. (2016) Adeno-myosis: A Systematic Review of Medical Treatment. Gynecological Endocrinology, 32, 696-700. https://doi.org/10.1080/09513590.2016.1197200 |
[34] | Kuan-HaoTsui, W.-L., Chen, C.-Y., Sheu, B.-C., et al. (2014) Medical Treatment for Adenomyosis and/or Adenomyoma. Taiwanese Journal of Obstetrics and Gynecology, 53, 459-465. https://doi.org/10.1016/j.tjog.2014.04.024 |
[35] | Harada, T. and Taniguchi, F. (2010) Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis. Women’s Health, 6, 27-35. https://doi.org/10.2217/WHE.09.72 |
[36] | 彭超, 周应芳. 子宫腺肌病药物治疗选择及长期管理[J]. 中国实用妇科与产科杂志, 2019, 35(5): 516-519. |