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幽门螺杆菌及其血清学分型在胃癌中的意义
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Abstract:
胃癌是世界上最常见的恶性肿瘤之一。胃癌是由于多种因素的共同作用而导致，幽门螺杆菌与胃癌的发生发展密切相关，幽门螺杆菌是WHO认定的胃癌首要致癌因子，对胃癌患者的预后有着极大影响。幽门螺杆菌拥有多种毒力因子，包括细胞毒素相关蛋白(CagA)、空泡毒素相关蛋白(VacA)以及尿素酶等，基于这些毒力因子的幽门螺杆菌的血清学分型与其致病力密切相关。因此，继续研究幽门螺杆菌及其血清分型对胃癌的发生发展以及预后是相当重要的。
Gastric cancer is one of the most common malignant tumors in the world. Gastric cancer is caused by a variety of factors. Helicobacter pylori is closely related to the occurrence and development of gastric cancer. Helicobacter pylori is the primary carcinogen of gastric cancer recognized by WHO, which has a great impact on the prognosis of patients with gastric cancer. Helicobacter pylori has a variety of virulence factors, including cytotoxin associated gene A (CagA), vacuolating cytotoxin A (VacA) and urease. The serotyping of Helicobacter pylori based on these virulence factors is closely related to its pathogenicity. Therefore, it is very important to continue to study Helicobacter pylori and its serotyping for the occurrence, development and prognosis of gastric cancer.
| [1] | Sung, H., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. https://doi.org/10.3322/caac.21660 |
| [2] | Inoue, M. (2021) Public Health Interventions for Gastric Cancer Control. Gastrointestinal Endoscopy Clinics of North America, 31, 441-449. https://doi.org/10.1016/j.giec.2021.03.002 |
| [3] | Huang, R.J. and Hwang, J.H. (2021) Improving the Early Diag-nosis of Gastric Cancer. Gastrointestinal Endoscopy Clinics of North America, 31, 503-517. https://doi.org/10.1016/j.giec.2021.03.005 |
| [4] | 贠建蔚, 齐国卿, 张德奎. 幽门螺杆菌分型的研究现状[J]. 中华传染病杂志, 2021, 39(4): 243-247. |
| [5] | Shafaie, E., et al. (2018) Multiplex Serology of Helicobacter pylori Anti-gens in Detection of Current Infection and Atrophic Gastritis—A Simple and Cost-Efficient Method. Microbial Path-ogenesis, 119, 137-144.
https://doi.org/10.1016/j.micpath.2018.04.018 |
| [6] | Alipour, M. (2021) Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer. Journal of Gastrointestinal Cancer, 52, 23-30. https://doi.org/10.1007/s12029-020-00518-5 |
| [7] | Cheok, Y.Y., et al. (2021) An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment. Microorganisms, 9, 2502. https://doi.org/10.3390/microorganisms9122502 |
| [8] | Ansari, S. and Yamaoka, Y. (2017) Survival of Helicobacter pylori in Gastric Acidic Territory. Helicobacter, 22, e12386. https://doi.org/10.1111/hel.12386 |
| [9] | Padda, J., et al. (2021) Association between Helicobacter pylori and Gastric Carcinoma. Cureus, 13, e15165.
https://doi.org/10.7759/cureus.15165 |
| [10] | Camilo, V., Sugiyama, T. and Touati, E. (2017) Pathogenesis of Helico-bacter pylori Infection. Helicobacter, 22, e12405.
https://doi.org/10.1111/hel.12405 |
| [11] | Liu, W., et al. (2021) A Retrospective Study Assessing the Acceleration Effect of Type I Helicobacter pylori Infection on the Progress of Atrophic Gastritis. Scientific Reports, 11, Article No. 4143.
https://doi.org/10.1038/s41598-021-83647-6 |
| [12] | Sharndama, H.C. and Mba, I.E. (2022) Helicobacter pylori: An Up-to-Date Overview on the Virulence and Pathogenesis Mechanisms. Brazilian Journal of Microbiology, 53, 33-50. https://doi.org/10.1007/s42770-021-00675-0 |
| [13] | Bakhti, S.Z., et al. (2019) Inverse Association of Helicobacter pylori cagPAI Genotypes with Risk of Cardia and Non-Cardia Gastric Adenocarcinoma. Cancer Medicine, 8, 4928-4937. https://doi.org/10.1002/cam4.2390 |
| [14] | Tegtmeyer, N., et al. (2017) Subversion of Host Kinases: A Key Network in Cellular Signaling Hijacked by Helicobacter pylori CagA. Molecular Microbiology, 105, 358-372. https://doi.org/10.1111/mmi.13707 |
| [15] | Takahashi-Kanemitsu, A., Knight, C.T. and Hatakeyama, M. (2020) Molecular Anatomy and Pathogenic Actions of Helicobacter pylori CagA That Underpin Gastric Carcinogenesis. Cel-lular and Molecular Immunology, 17, 50-63.
https://doi.org/10.1038/s41423-019-0339-5 |
| [16] | Ansari, S. and Yamaoka, Y. (2020) Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity. International Journal of Molecular Sciences, 21, 7430.
https://doi.org/10.3390/ijms21197430 |
| [17] | 万秀坤, 刘纯杰. 幽门螺杆菌CagA蛋白及其致病机制的研究进展[J]. 微生物学报, 2016, 56(12): 1821-1830. |
| [18] | Yuan, X.Y., et al. (2017) Helicobacter pylori with East Asian-Type cagPAI Genes Is More Virulent than Strains with Western-Type in Some cagPAI Genes. Brazilian Journal of Microbi-ology, 48, 218-224.
https://doi.org/10.1016/j.bjm.2016.12.004 |
| [19] | Hatakeyama, M. (2017) Structure and Function of Helicobacter pylori CagA, the First-Identified Bacterial Protein Involved in Human Cancer. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 93, 196-219.
https://doi.org/10.2183/pjab.93.013 |
| [20] | Sulzmaier, F.J., Jean, C. and Schlaepfer, D.D. (2014) FAK in Cancer: Mechanistic Findings and Clinical Applications. Nature Reviews Cancer, 14, 598-610. https://doi.org/10.1038/nrc3792 |
| [21] | Tsutsumi, R., et al. (2006) Focal Adhesion Kinase Is a Substrate and Down-stream Effector of SHP-2 Complexed with Helicobacter pylori CagA. Molecular and Cellular Biology, 26, 261-276.
https://doi.org/10.1128/MCB.26.1.261-276.2006 |
| [22] | Saadat, I., et al. (2007) Helicobacter pylori CagA Targets PAR1/MARK Kinase to Disrupt Epithelial Cell Polarity. Nature, 447, 330-333. https://doi.org/10.1038/nature05765 |
| [23] | Rasi-Bonab, F., et al. (2021) Antibiotic Resistance Pattern and Frequency of cagA and vacA Genes in Helicobacter pylori Strains Isolated from Patients in Tabriz City, Iran. BMC Research Notes, 14, Article No. 216.
https://doi.org/10.1186/s13104-021-05633-5 |
| [24] | Chauhan, N., et al. (2019) Helicobacter pylori VacA, a Distinct Toxin Exerts Diverse Functionalities in Numerous Cells: An Overview. Helicobacter, 24, e12544. https://doi.org/10.1111/hel.12544 |
| [25] | McClain, M.S., Beckett, A.C. and Cover, T.L. (2017) Helicobacter pylori Vacuolating Toxin and Gastric Cancer. Toxins (Basel), 9, 316. https://doi.org/10.3390/toxins9100316 |
| [26] | Kim, J. and Wang, T.C. (2021) Helicobacter pylori and Gastric Cancer. Gastrointestinal Endoscopy Clinics of North America, 31, 451-465. https://doi.org/10.1016/j.giec.2021.03.003 |
| [27] | Li, H., et al. (2019) How Does Helicobacter pylori Cause Gastric Cancer through Connexins: An Opinion Review. World Journal of Gastroenterology, 25, 5220-5232. https://doi.org/10.3748/wjg.v25.i35.5220 |
| [28] | Sukri, A., et al. (2020) Epidemiology and Role of Helicobacter pylori Virulence Factors in Gastric Cancer Carcinogenesis. APMIS, 128, 150-161. https://doi.org/10.1111/apm.13034 |
| [29] | Abdullah, M., et al. (2019) VacA Promotes CagA Accumulation in Gastric Epithelial Cells during Helicobacter pylori Infection. Scientific Reports, 9, Article No. 38. https://doi.org/10.1038/s41598-018-37095-4 |
| [30] | Tarsia, C., et al. (2018) Targeting Helicobacter pylori Urease Activity and Maturation: In-Cell High-Throughput Approach for Drug Discovery. Biochimica et Biophysica Acta (BBA)—General Subjects, 1862, 2245-2253.
https://doi.org/10.1016/j.bbagen.2018.07.020 |
| [31] | Ha, N.-C., et al. (2001) Supramolecular Assembly and Acid Resistance of Helicobacter pylori Urease. Nature Structural Biology, 8, 505-509. https://doi.org/10.1038/88563 |
| [32] | Olivera-Severo, D., et al. (2017) A New Role for Helicobacter pylori Urease: Contributions to Angiogenesis. Frontiers in Microbiology, 8, Article No. 1883. https://doi.org/10.3389/fmicb.2017.01883 |
| [33] | Debowski, A.W., et al. (2017) Helicobacter pylori Gene Silencing in Vivo Demonstrates Urease Is Essential for Chronic Infection. PLOS Pathogens, 13, e1006464. https://doi.org/10.1371/journal.ppat.1006464 |
| [34] | Baj, J., et al. (2020) Helicobacter pylori Virulence Fac-tors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment. Cells, 10, 27. https://doi.org/10.3390/cells10010027 |
| [35] | Foegeding, N.J., et al. (2019) Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability. Infection and Immunity, 87, e00783-18. https://doi.org/10.1128/IAI.00783-18 |
| [36] | Schmalstig, A.A., et al. (2018) Noncatalytic Antioxidant Role for Helicobacter pylori Urease. Journal of Bacteriology, 200, e00124-18. https://doi.org/10.1128/JB.00124-18 |
| [37] | Lee, J.H., et al. (2015) Morphological Changes in Human Gastric Epi-thelial Cells Induced by Nuclear Targeting of Helicobacter pylori Urease Subunit A. Journal of Microbiology, 53, 406-414.
https://doi.org/10.1007/s12275-015-5085-5 |
| [38] | Valenzuela-Valderrama, M., et al. (2019) The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1alpha in Gastric Cells. Cancers (Basel), 11, 799.
https://doi.org/10.3390/cancers11060799 |
| [39] | Graham, D.Y. and Miftahussurur, M. (2018) Helicobacter pylori Urease for Diagnosis of Helicobacter pylori Infection: A Mini Review. Journal of Advanced Research, 13, 51-57. https://doi.org/10.1016/j.jare.2018.01.006 |
| [40] | Mohammadian, T. and Ganji, L. (2019) The Diagnostic Tests for Detection of Helicobacter pylori Infection. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 38, 1-7. https://doi.org/10.1089/mab.2018.0032 |
| [41] | O’Connor, A. (2021) The Urea Breath Test for the Noninvasive De-tection of Helicobacter pylori. Methods in Molecular Biology, 2283, 15-20. https://doi.org/10.1007/978-1-0716-1302-3_2 |
| [42] | Zhou, J.T., et al. (2017) Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism. PLOS ONE, 12, e0168944. https://doi.org/10.1371/journal.pone.0168944 |
| [43] | Li, C., et al. (2018) Coptisine-Induced Inhibition of Helico-bacter pylori: Elucidation of Specific Mechanisms by Probing Urease Active Site and Its Maturation Process. Journal of Enzyme Inhibition and Medicinal Chemistry, 33, 1362-1375. https://doi.org/10.1080/14756366.2018.1501044 |
| [44] | Mamidala, R., Bhimathati, S.R.S. and Vema, A. (2021) Discovery of Novel Dihydropyrimidine and Hydroxamic Acid Hybrids as Potent Helicobacter pylori Urease Inhibitors. Bioorganic Chemistry, 114, Article ID: 105010.
https://doi.org/10.1016/j.bioorg.2021.105010 |
| [45] | Dos Santos Viana, I., et al. (2021) Vaccine Development against Helicobacter pylori: From Ideal Antigens to the Current Landscape. Expert Review of Vaccines, 20, 989-999. https://doi.org/10.1080/14760584.2021.1945450 |
| [46] | Ichihara, A., et al. (2021) Serodiagnosis and Bacterial Ge-nome of Helicobacter pylori Infection. Toxins (Basel), 13, 467. https://doi.org/10.3390/toxins13070467 |
| [47] | Jeske, R., et al. (2020) Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study. Cancer Epidemiology, Biomarkers & Prevention, 29, 2235-2242. https://doi.org/10.1158/1055-9965.EPI-20-0348 |
| [48] | Yuan, L., et al. (2020) Type I and Type II Helicobacter pylori Infection Status and Their Impact on Gastrin and Pepsinogen Level in a Gastric Cancer Prevalent Area. World Journal of Gastroenterology, 26, 3673-3685.
https://doi.org/10.3748/wjg.v26.i25.3673 |
| [49] | El Hafa, F., et al. (2022) Association between Helicobacter pylori Antibodies Determined by Multiplex Serology and Gastric Cancer Risk: A Meta-Analysis. Helicobacter, 27, e12881. https://doi.org/10.1111/hel.12881 |
| [50] | Liu, W., Sun, Y. and Yuan, Y. (2020) Analysis of Serum Gastrin-17 and Helicobacter pylori Antibody in Healthy Chinese Population. Journal of Clinical Laboratory Analysis, 34, e23518. https://doi.org/10.1002/jcla.23518 |
| [51] | Lin, Z., et al. (2021) Application of Serum Pepsinogen and Carbohydrate Antigen 72-4 (CA72-4) Combined with Gastrin-17 (G-17) Detection in the Screening, Diagnosis, and Evaluation of Early Gastric Cancer. Journal of Gastrointestinal Oncology, 12, 1042-1048. https://doi.org/10.21037/jgo-21-254 |
| [52] | Han, X.L., et al. (2022) Clinical Value of Pepsinogen in the Screening, Prevention, and Diagnosis of Gastric Cancer. Laboratory Medicine, 53, 71-77. https://doi.org/10.1093/labmed/lmab035 |
| [53] | Kishk, R.M., et al. (2021) Genotyping of Helicobacter pylori Viru-lence Genes cagA and vacA: Regional and National Study. International Journal of Microbiology, 2021, Article ID: 5540560. https://doi.org/10.1155/2021/5540560 |
| [54] | 国家消化系疾病临床医学研究中心, 国家消化道早癌防治中心联盟(GECA), 中华医学会消化病学分会幽门螺杆菌学组, 等. 中国幽门螺杆菌根除与胃癌防控的专家共识意见(2019年, 上海) [J]. 中华消化杂志, 2019, 39(5): 310-316. |
| [55] | Li, Y., et al. (2021) Genotyping Helicobacter pylori Antibiotic Resistance and Virulence-Associated Genes in Patients with Gastric Cancer in Wenzhou, China. Arab Journal of Gastroenterology, 22, 267-271.
https://doi.org/10.1016/j.ajg.2021.05.017 |
| [56] | Suzuki, S., et al. (2022) The Ideal Helicobacter pylori Treatment for the Present and the Future. Digestion, 103, 62-68.
https://doi.org/10.1159/000519413 |
