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儿童感染后闭塞性细支气管炎治疗进展
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Abstract:
闭塞性细支气管炎(Bronchiolitis Obliterans, BO)是一组以反复或持续性呼吸困难及气流受阻为主要特点的慢性气流阻塞综合征。感染是儿童BO的最主要病因，又称为感染后闭塞性细支气管炎(Post-infection Bronchiolitis Obliterans, PIBO)。PIBO目前尚无特效治疗，主要药物治疗包括糖皮质激素、阿奇霉素、白三烯受体拮抗剂、支气管扩张剂，非药物治疗包括肺康复训练、营养支持。间充质干细胞、靶向药物治疗可作为未来PIBO治疗的新方向。PIBO早期干预有助于改善患儿预后，现主要就PIBO的治疗进展作一综述。
Bronchiolitis Obliterans (BO) is a chronic airflow obstruction syndrome characterized by recurrent or persistent dyspnea and airflow obstruction. Infection is the primary cause of BO in children, also known as post-infection bronchiolitis obliterans (PIBO). Nowadays, there is no specific treatment, glucocorticoid, azithromycin, leukotriene receptor antagonist and bronchodilator are mainly used in drug therapy. The main non-drug therapy is pulmonary rehabilitation training and nutritional support. Early intervention can improve the prognosis, in this article, the treatment of PIBO is introduced mainly.
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