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唑类药物的耐药机制及结构修饰研究进展
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Abstract:
侵袭性真菌疾病对公共卫生构成了威胁。唑类药物可以通过抑制麦角固醇的合成来治疗真菌疾病，但唑类药物的广泛使用导致真菌产生了耐药性，使得临床治疗失败。所以，研发新的抗真菌化合物十分重要。本文介绍了现有抗真菌药物的分类及唑类药物的作用机制、结构修饰及耐药机制。这有利于更好的认识目前唑类药物的情况，以期促进新型抗真菌药物的研发。
Invasive fungal diseases pose a threat to public health. Azole drugs can be used to treat fungal diseases by inhibiting the synthesis of ergosterol, but the widespread use of azole drugs leads to the development of drug resistance in fungi, which makes clinical treatment failure. Therefore, it is very important to develop new antifungal compounds. In this paper, the classification of antifungal drugs and the mechanism of action, structural modification and resistance of azole drugs were introduced. This is conducive to a better understanding of the current situation of azole drugs, in order to promote the development of new antifungal drugs.
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