Background: To compare central corneal thickness (CCT) values measured in diabetic eyes and compare the CCT values in normal patients without diabetes. Methods: A total of 83 diabetic patients and 83 non-diabetic patients were prospectively enrolled in this comparative case series. CCT was measured using a Topcon CT-1P non-contact automated pachymeter, and values were compared. Results: Mean age was 57 ± 11 years, with a range of 23 and 80 years. The mean CCT was 508.87 ± 35.83 μm for diabetic patients and 513.41 ± 37.22 μm for non-diabetic patients. There was no statistically significant difference between the CCT of diabetic patients compared to non-diabetic patients (p = 0.260). We did not find a significant correlation between the CCT of diabetic patients and clinical characteristics of diabetes. However, there was a positive and statistically significant linear correlation between the CCT of diabetic patients and intra ocular pressure (IOP). Conclusion: The mean CCT in diabetic patients was lower than in non-diabetic control patients, although there was no statistically significant difference.
References
[1]
Burton, M.J., Ramke, J., Marques, A.P., Bourne, R.R.A., Congdon, N., Jones, I., et al. (2021) The Lancet Global Health Commission on Global Eye Health: Vision beyond 2020. The Lancet Global Health, 9, E489-E551. https://doi.org/10.1016/S2214-109X(20)30488-5
[2]
Organisation Mondiale de la Santé—Profils des pays pour le diabète 2016.
[3]
Bourne, R.R., Stevens, G.A., White, R.A., et al. (2013) Vision Loss Expert Group. Causes of Vision Loss Worldwide, 1990-2010: A Systematic Analysis. The Lancet Global Health, 1, E339-E349. https://doi.org/10.1016/S2214-109X(13)70113-X
[4]
Herse, P.R. (1988) A Review of Manifestations of Diabetes Mellitus in the Anterior Eye and Cornea. American Journal of Optometry and Physiological Optics, 65, 224-230. https://doi.org/10.1097/00006324-198803000-00013
[5]
Chawla, R. (2012) Complications of Diabetes. Jaypee Brothers Medical Publishers, New Delhi.
[6]
Storr-Paulsen, A., Singh, A., Jeppesen, H., Norregaard, J. and Thulesen, J. (2013) Corneal Endothelial Morphology and Central Thickness in Patients with Type II Diabetes Mellitus. Acta Ophthalmologica, 92, 158-160. https://doi.org/10.1111/aos.12064
[7]
Su, D.H., Wong, T.Y., Wong, W.L., Saw, S.M., Tan, D.T., Shen, S.Y., et al., Singapore Malay Eye Study Group (2008) Diabetes, Hyperglycemia, and Central Corneal Thickness: The Singapore Malay Eye Study. Ophthalmology, 115, 964-968. https://doi.org/10.1016/j.ophtha.2007.08.021
[8]
Nishitsuka, K., Kawasaki, R., Kanno, M., Tanaba, Y., Saito, K., Honma, K., et al., for the Funagata Study (2011) Determinants and Risk Factors for Central Corneal Thickness in Japanese Persons: The Funagata Study. Ophthalmic Epidemiology, 18, 244-249. https://doi.org/10.3109/09286586.2011.594206
[9]
Bascaran, C., Zondervan, M., Walker, C., Astbury, N.J. and Foste, A. (2022) Diabetic Retinopathy in Africa. Eye (Lond), 36, 1-3. https://doi.org/10.1038/s41433-022-01999-3
[10]
Song, B.J., Aiello, L.P. and Pasquale, L.R. (2016) Pasquale Presence and Risk Factors for Glaucoma in Patients with Diabetes. Current Diabetes Reports, 16, Article No. 124. https://doi.org/10.1007/s11892-016-0815-6
[11]
Priyadarsini, S., Whelchel, A., Nicholas, S., Sharif, R., Riaz, K. and Karamichos, D. (2020) Diabetic Keratopathy: Insights and Challenges. Survey of Ophthalmology, 65, 513-529. https://doi.org/10.1016/j.survophthal.2020.02.005
[12]
Chowdhury, B., Bhadra, S., Mittal, P. and Shyam, K. (2021) Corneal Endothelial Morphology and Central Corneal Thickness in Type 2 Diabetes Mellitus Patients. Indian Journal of Ophthalmology, 69, 1718-1724. https://doi.org/10.4103/ijo.IJO_3120_20
[13]
Módis Jr., L., Szalai, E., Kertész, K., Kemény-Beke, A., Kettesy, B., Berta, A., et al. (2010) Evaluation of the Corneal Endothelium in Patients with Diabetes Mellitus Type I and II. Histology and Histopathology, 25, 1531-1537.
[14]
Massin, P., Feldman, S., Angioi-Duprez, K., Conrath, J., Creuzot-Garcher, C., Delfer, M., et al. (2016) Référentiel pour le dépistage et la surveillance des complications oculaires des patients diabétiques. SFD, 10, 778-779. https://doi.org/10.1016/S1957-2557(16)30224-3
[15]
Yusufoğlu, E., Kobat, S.G. and Keser, S. (2022) Evaluation of Central Corneal Epithelial Thickness with Anterior Segment OCT in Patients with Type 2 Diabetes Mellitus. International Ophthalmology. https://doi.org/10.21203/rs.3.rs-1225167/v1
[16]
Panagiota, P., Irini, C., Miltiadis, P., Vaia, L., Charalambos, S., Panagioti, S., et al. (2020) The Effect of Diabetes Mellitus on Corneal Endothelial and Central Corneal Thickness: A Case-Control Study. Ophthalmic Research, 63, 550-554. https://doi.org/10.1159/000507197
[17]
El-Agamy, A. and Alsubaie, S. (2017) Corneal Endothelium and Central Corneal Thickness Changes in Type 2 Diabetes Mellitus. Clinical Ophthalmology, 11, 481-486. https://doi.org/10.2147/OPTH.S126217
[18]
Toygar, O., Sizmaz, S., Pelit, A., Toygar, B., Yabaş Kiziloğlu, Ö. and Akova, Y. (2015) Central Corneal Thickness in Type II Diabetes Mellitus: Is It Related to the Severity of Diabetic Retinopathy? Turkish Journal of Medical Sciences, 45, 651-654. https://doi.org/10.3906/sag-1404-153
[19]
Taşlı, N.G., Icel, E., Karakurt, Y., Ucak, T., Ugurlu, A., Yilmaz, H. and Akbas, E.M. (2020) The Findings of Corneal Specular Microscopy in Patients with Type-2 Diabetes Mellitus. BMC Ophthalmology, 20, Article No. 214. https://doi.org/10.1186/s12886-020-01488-9