Background: Acute kidney injury (AKI) is frequently reported in the context of coronavirus infection. The incidence of AKI, particularly in patients hospitalized in intensive care units, is high. The aim was to study the associated factors to mortality in acute kidney injury (AKI) during COVID-19 in Togo. Method: This was a cross-sectional analytical study with retrospective data collection. It involved all patients hospitalized at CHR-LC from March 2020 to August 2021 suffering from COVID-19 who presented an AKI. Results: We identified 113 cases of acute kidney injury according to the predefined criteria. The prevalence of AKI during COVID-19 was 3.90%. Subjects over 65 years of age were the most represented. The age extremes were 17 and 85 years. The sex ratio (M/F) was 2.89. The main factors significantly associated with the severity of acute kidney injury were diabetes, asthma, HIV infection, and stroke. There was a correlation between the degree of acute kidney failure and severity on admission. Patients with AKI severity 2 and 3 were on hemodialysis. There was a statistically significant correlation between intra-hospital mortality and the severity of acute kidney injury (p = 0.04). The intra-hospital mortality rate was 23%. Conclusion: Acute kidney injury (AKI) during COVID-19 is a real concern for clinicians. Its medical care involves a multidisciplinary team. Particular emphasis should therefore be placed on the management of comorbidities and preventive nephroprotection measures.
References
[1]
Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J.-C., Turner, A.J., et al. (2020) Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2. Circulation Research, 126, 1456-1474. https://doi.org/10.1161/CIRCRESAHA.120.317015
[2]
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., et al. (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382, 1708-1720. https://doi.org/10.1056/NEJMoa2002032
[3]
Yang, X., Yu, Y., Xu, J., Shu, H., Liu, H., Wu, Y., et al. (2020) Clinical Course and Outcomes of Critically Ill Patients with SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. The Lancet Respiratory Medicine, 8, 475-481. https://doi.org/10.1016/S2213-2600(20)30079-5
[4]
Cheng, Y., Luo, R., Wang, K., Zhang, M., Wang, Z., Dong, L., et al. (2020) Kidney Disease Is Associated with In-Hospital Death of Patients with COVID-19. Kidney International, 97, 829-838. https://doi.org/10.1016/j.kint.2020.03.005
[5]
El Aidaoui, K., Haoudar, A., Khalis, M., Kantri, A., Ziati, J., El Ghanmi, A., et al. (2020) Predictors of Severity in Covid-19 patients in Casablanca, Morocco. Cureus, 12, e10716. https://doi.org/10.7759/cureus.10716
[6]
Kellum, J.A., Lameire, N., Aspelin, P., Barsoum, R.S., Burdmann, E.A., Goldstein, S.L., et al. (2012) Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements, 2, 1-138.
[7]
Gaudry, S., Hajage, D., Benichou, N., Chaïbi, K., Barbar, S., Zarbock, A., et al. (2020) Delayed versus Early Initiation of Renal Replacement Therapy for Severe Acute Kidney Injury: A Systematic Review and Individual Patient Data Meta-Analysis of Randomised Clinical Trials. The Lancet, 395, 1506-1515. https://doi.org/10.1016/S0140-6736(20)30531-6
[8]
Sang, L., Chen, S., Zheng, X., Guan, W., Zhang, Z., Liang, W., et al. (2020) The Incidence, Risk Factors and Prognosis of Acute Kidney Injury in Severe and Critically Ill Patients with COVID-19 in Mainland China: A Retrospective Study. BMC Pulmonary Medicine, 20, Article No. 290. https://doi.org/10.1186/s12890-020-01305-5
[9]
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. (2020) Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Descriptive Study. The Lancet, 395, 507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
[10]
Zamoner, W., Santos, S., Magalhäes, L., Oliveira, P., Balbi, A. and Ponce, D. (2021) Acute Kidney Injury in COVID-19: 90 Days of the Pandemic in a Brazilian Public Hospital. Frontiers in Medicine, 8, Article ID: 622577. https://doi.org/10.3389/fmed.2021.622577
