全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Photobiomodulation with Super-Pulsed Laser Shows Efficacy for Stroke and Aphasia: Case Studies

DOI: 10.4236/wjns.2023.131002, PP. 12-20

Keywords: Low-Level Laser Therapy, Photobiomodulation, Stroke Rehabilitation, Traumatic Brain Injury, Alzheimer’s Disease, Aphasia

Full-Text   Cite this paper   Add to My Lib

Abstract:

Background: Brain disorders have become more and more common today, due to both the aging population and the ever-expanding sports community. However, a new therapeutic technology called photobiomodulation (PBM) is giving hope to thousands of individuals in need. Traumatic brain injury (TBI), dementia, post traumatic stress (PTSD) and attention deficit (ADD) disorders are in many cases quickly and safely improved by PBM. PBM employs red or near-infrared (NIR) light (600 - 1100 nm) to stimulate healing, protect tissue from dying, increase mitochondrial function, improve blood flow, and tissue oxygenation. PBM can also act to reduce edema, increase antioxidants, decrease inflammation, protect against apoptosis, and modulate the microglial activation state. All these effects can occur when light is delivered to the head, and can be beneficial in both acute and chronic brain conditions. Methods: In this case series, we used a high power, FDA-approved superpulsed laser system applied to the head to treat four chronic stroke patients. Patients received as few as three 6 - 9 minute treatments over a one-week period. The follow up time varied, but in one case was two years. Results: Patients showed significant improvement in their speech and verbal skills. Improvements were also noticed in walking ability, limb movement, less numbness, and better vision. Conclusion: The use of PBM in stroke rehabilitation deserves to be tested in controlled clinical trials, because this common condition has no approved pharmaceutical treatment at present.

References

[1]  Lazar, R.M. and Boehme, A.K. (2017) Aphasia as a Predictor of Stroke Outcome. Current Neurology and Neuroscience Reports, 17, 83.
https://doi.org/10.1007/s11910-017-0797-z
[2]  Saver, J.L. (2006) Time Is Brain—Quantified. Stroke, 37, 263-266.
https://doi.org/10.1161/01.STR.0000196957.55928.ab
[3]  Unnithan, A.K.A., Das, J.M. and Mehta, P. (2022) Hemorrhagic Stroke. StatPearls Publishing, Treasure Island.
[4]  Virani, S.S., Alonso, A., Benjamin, E.J., et al. (2020) Heart Disease and Stroke Statistics—2020 Update: A Report from the American Heart Association. Circulation, 141, e139-e596.
https://doi.org/10.1161/CIR.0000000000000746
[5]  Hamblin, M.R., Agrawal, T. and de Sousa, M.V. (2016) Handbook of Low-Level Laser Therapy. CRC Press, Boca Raton.
https://doi.org/10.1201/9781315364827
[6]  Hamblin, M.R. (2016) Shining Light on the Head: Photobiomodulation for Brain Disorders. BBA Clinical, 6, 113-124.
https://doi.org/10.1016/j.bbacli.2016.09.002
[7]  Hamblin, M.R. (2018) Photobiomodulation for Traumatic Brain Injury and Stroke. Journal of Neuroscience Research, 96, 731-743.
https://doi.org/10.1002/jnr.24190
[8]  Naeser, M.A., Saltmarche, A., Krengel, M.H., et al. (2011) Improved Cognitive Function after Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports. Photomedicine and Laser Surgery, 29, 351-358.
https://doi.org/10.1089/pho.2010.2814
[9]  Naeser, M.A., Zafonte, R., Krengel, M.H., et al. (2014) Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study. Journal of Neurotrauma, 31, 1008-1017.
https://doi.org/10.1089/neu.2013.3244
[10]  Naeser, M.A., Ho, M.D., Martin, P.I., et al. (2019) Increased Functional Connectivity within Intrinsic Neural Networks in Chronic Stroke Following Treatment with Red/Near-Infrared Transcranial Photobiomodulation: Case Series with Improved Naming in Aphasia. Photobiomodulation, Photomedicine, and Laser Surgery, 38, 115-131.
https://doi.org/10.1089/photob.2019.4630
[11]  de Freitas, L.F. and Hamblin, M.R. (2016) Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE Journal of Selected Topics in Quantum Electronics, 22, Article ID: 7000417.
https://doi.org/10.1109/JSTQE.2016.2561201
[12]  Sharma, S.K., Kharkwal, G.B., Sajo, M., et al. (2011) Dose Response Effects of 810 nm Laser Light on Mouse Primary Cortical Neurons. Lasers in Surgery and Medicine, 43, 851-859.
https://doi.org/10.1002/lsm.21100
[13]  Eshaghi, E., Sadigh-Eteghad, S., Mohaddes, G., et al. (2019) Transcranial Photobiomodulation Prevents Anxiety and Depression via Changing Serotonin and Nitric Oxide Levels in Brain of Depression Model Mice: A Study of Three Different Doses of 810 nm Laser. Lasers in Surgery and Medicine, 51, 634-642.
https://doi.org/10.1002/lsm.23082
[14]  Yang, L., Tucker, D., Dong, Y., et al. (2018) Photobiomodulation Therapy Promotes Neurogenesis by Improving Post-Stroke Local Microenvironment and Stimulating Neuroprogenitor Cells. Experimental Neurology, 299, 86-96.
https://doi.org/10.1016/j.expneurol.2017.10.013
[15]  Davies, D., Hadis, M., Di Pietro, V., et al. (2022) Photobiomodulation Reduces Hippocampal Apoptotic Cell Death and Produces a Raman Spectroscopic “Signature”. PLOS ONE, 17, e0264533.
https://doi.org/10.1371/journal.pone.0264533
[16]  Chao, L.L. (2019) Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial. Photobiomodulation, Photomedicine, and Laser Surgery, 37, 133-141.
https://doi.org/10.1089/photob.2018.4555
[17]  Hamblin, M.R. and Huang, Y.Y. (2019) Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience. Academic Press, Amsterdam.
[18]  Hamblin, M.R. (2019) Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned? Photonics, 6, 77.
https://doi.org/10.3390/photonics6030077
[19]  Qi, X., Nizamutdinov, D., Berman, M.H., et al. (2021) Gender Differences of Dementia in Response to Intensive Self-Administered Transcranial and Intraocular Near-Infrared Stimulation. Cureus, 13, e16188.
https://doi.org/10.7759/cureus.16188
[20]  Huang, J.H., Stevens, A.B., Yi, S.S., et al. (2021) Transcranial near Infrared Light Stimulations Improve Cognition in Patients with Dementia. Aging and Disease, 12, 954.
https://doi.org/10.14336/AD.2021.0229
[21]  Saltmarche, A.E., Naeser, M.A., Ho, K.F., et al. (2017) Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomedicine and Laser Surgery, 35, 432-441.
https://doi.org/10.1089/pho.2016.4227
[22]  Salehpour, F., Hamblin, M.R. and DiDuro, J.O. (2019) Rapid Reversal of Cognitive Decline, Olfactory Dysfunction, and Quality of Life Using Multi-Modality Photobiomodulation Therapy: Case Report. Photobiomodulation, Photomedicine, and Laser Surgery, 37, 159-167.
https://doi.org/10.1089/photob.2018.4569
[23]  Horner, S., Berger, L. and Gibas, K. (2020) Nutritional Ketosis and Photobiomodulation Remediate Mitochondria Warding off Alzheimer’s Disease in a Diabetic, ApoE4+ Patient with Mild Cognitive Impairment: A Case Report. Photodiagnosis and Photodynamic Therapy, 30, Article ID: 101777.
https://doi.org/10.1016/j.pdpdt.2020.101777
[24]  Gutiérrez-Menéndez, A., Marcos-Nistal, M., Méndez, M. and Arias, J.L. (2020) Photobiomodulation as a Promising New Tool in the Management of Psychological Disorders: A Systematic Review. Neuroscience & Biobehavioral Reviews, 119, 242-254.
https://doi.org/10.1016/j.neubiorev.2020.10.002
[25]  Stephan, W., Banas, L.J., Brierley, W. and Hamblin, M.R. (2022) Efficacy of Photobiomodulation for Attention Deficit Hyperactivity Disorder (ADHD): Case Studies. World Journal of Neuroscience, 12, 136-143.
https://doi.org/10.4236/wjns.2022.123015
[26]  Lampl, Y., Zivin, J.A., Fisher, M., et al. (2007) Infrared Laser Therapy for Ischemic Stroke: A New Treatment Strategy: Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke, 38, 1843-1849.
https://doi.org/10.1161/STROKEAHA.106.478230
[27]  Zivin, J.A., Albers, G.W., Bornstein, N., et al. (2009) Effectiveness and Safety of Transcranial Laser Therapy for Acute Ischemic Stroke. Stroke, 40, 1359-1364.
https://doi.org/10.1161/STROKEAHA.109.547547
[28]  Hacke, W., Schellinger, P.D., Albers, G.W., et al. (2014) Transcranial Laser Therapy in Acute Stroke Treatment: Results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial. Stroke, 45, 3187-3193.
https://doi.org/10.1161/STROKEAHA.114.005795
[29]  Stemer, A., Huisa, B.N. and Zivin, J.A. (2010) The Evolution of Transcranial Laser Therapy for Acute Ischemic Stroke, Including a Pooled Analysis of NEST-1 and NEST-2. Current Cardiology Reports, 12, 29-33.
https://doi.org/10.1007/s11886-009-0071-3
[30]  Ab Boonswang, N., Chicchi, M., Lukachek, A. and Curtiss, D. (2012) A New Treatment Protocol Using Photobiomodulation and Muscle/Bone/Joint Recovery Techniques Having a Dramatic Effect on a Stroke Patient’s Recovery: A New Weapon for Clinicians. Case Reports, 2012, bcr0820114689.
https://doi.org/10.1136/bcr.08.2011.4689
[31]  Yang, W.-H., Lin, S.-P. and Chang, S.-T. (2017) Case Report: Rapid Improvement of Crossed Cerebellar Diaschisis after Intravascular Laser Irradiation of Blood in a Case of Stroke. Medicine, 96, e5646.
https://doi.org/10.1097/MD.0000000000005646
[32]  Bracewell, R.M. (2003) Stroke: Neuroplasticity and Recent Approaches to Rehabilitation. Journal of Neurology, Neurosurgery & Psychiatry, 74, 1465.
https://doi.org/10.1136/jnnp.74.11.1465
[33]  Su, F. and Xu, W. (2020) Enhancing Brain Plasticity to Promote Stroke Recovery. Frontiers in Neurology, 11, Article ID: 554089.
https://doi.org/10.3389/fneur.2020.554089
[34]  Markus, H.S. (2021) Intensive Speech Therapy after Stroke. International Journal of Stroke, 16, 495-496.
https://doi.org/10.1177/17474930211027503
[35]  Ward, N.S., Brander, F. and Kelly, K. (2019) Intensive Upper Limb Neurorehabilitation in Chronic Stroke: Outcomes from the Queen Square Programme. Journal of Neurology, Neurosurgery & Psychiatry, 90, 498-506.
https://doi.org/10.1136/jnnp-2018-319954
[36]  Xuan, W., Agrawal, T., Huang, L., et al. (2015) Low-Level Laser Therapy for Traumatic Brain Injury in Mice Increases Brain Derived Neurotrophic Factor (BDNF) and Synaptogenesis. Journal of Biophotonics, 8, 502-511.
https://doi.org/10.1002/jbio.201400069
[37]  Xuan, W., Vatansever, F., Huang, L. and Hamblin, M.R. (2014) Transcranial Low-Level Laser Therapy Enhances Learning, Memory, and Neuroprogenitor Cells after Traumatic Brain Injury in Mice. Journal of Biomedical Optics, 19, Article ID: 108003.
https://doi.org/10.1117/1.JBO.19.10.108003
[38]  Schiffer, F., Reichmann, W., Flynn, E., Hamblin, M.R. and McCormack, H. (2020) A Novel Treatment of Opioid Cravings with an Effect Size of .73 for Unilateral Transcranial Photobiomodulation Over Sham. Frontiers in Psychiatry, 11, 827.
https://doi.org/10.3389/fpsyt.2020.00827
[39]  Hamblin, M.R. (2022) Could Photobiomodulation Treat Autism Spectrum Disorder? Photobiomodulation, Photomedicine, and Laser Surgery, 40, 367-369.
https://doi.org/10.1089/photob.2022.0051

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133