Collagen has been a component of skin care formulations for many years, and over this time, there have been numerous claims of its efficiency. Collagen protein is responsible for firm strong skin, but since collagen fibers are too large to penetrate the stratum corneum (SC), topical creams containing collagen fibers remain on the skin surface without affecting skin quality. To overcome the poor penetration of collagen fibers, we prepared in the past micronized collagen fibers that were proven to reach the epidermis layer while inserted in a cream. In the present paper, we have performed a clinical study that analyzes the effect of the micronized fibrillar collagen containing cream on skin. Fifty five healthy female volunteers were enrolled and completed the study. The anti-ageing, firming, elasticity and moisturization efficacy of the cream were measured using Profilometer, Cutometer and Corneometer respectively. The results showed a significant improvement in skin hydration firmness and elasticity, a significant reduction in fine lines and wrinkles was also observed.
References
[1]
Avila Rodríguez, M.I., Rodríguez Barroso, L.G. and Sánchez, M.L. (2018) Collagen: A Review on Its Sources and Potential Cosmetic Applications. Journal of Cosmetic Dermatology, 17, 20-26. https://doi.org/10.1111/jocd.12450
[2]
Reilly, D.M. and Lozano, J. (2021) Skin Collagen through the Lifestages: Importance for Skin Health and Beauty. Plastic and Aesthetic Research, 8, 2. https://doi.org/10.20517/2347-9264.2020.153
[3]
Sionkowska, A., Skrzyński, S., Śmiechowski, K. and Kołodziejczak, A. (2017) The Review of Versatile Application of Collagen. Polymers for Advanced Technologies, 28, 4-9. https://doi.org/10.1002/pat.3842
[4]
Coapman, S.D., Lichtin, J.L., Sakr, A. and Schiltz, J.R. (1988) Studies of the Penetration of Native Collagen, Collagen Alpha Chains, and Collagen Cyanogen Bromide Peptides through Hairless Mouse Skin in Vitro. Journal of the Society of Cosmetic Chemists, 281, 275-281.
[5]
Aguirre-Cruz, G., León-López, A., Cruz-Gómez, V., Jiménez-Alvarado, R. and Aguirre-álvarez, G. (2020) Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants, 9, 181. https://doi.org/10.3390/antiox9020181
[6]
León-López, A., Morales-Peñaloza, A., Martínez-Juárez, V.M., Vargas-Torres, A., Zeugolis, D.I. and Aguirre-álvarez, G. (2019) Hydrolyzed Collagen-Sources and Applications. Molecules, 24, 4031. https://doi.org/10.3390/molecules24224031
[7]
Lubart, R., Yariv, I., Fixler, D. and Lipovsky, A. (2022) A Novel Facial Cream Based on Skin-Penetrable Fibrillar Collagen Microparticles. Journal of Clinical and Aesthetical Dermatology, 15, 59-64.
[8]
Association, W.M. (2013) World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310, 2191-2194. https://doi.org/10.1001/jama.2013.281053
[9]
International Conference on Harmonisation of Technical Requirements for the Registration of Pharmaceuticals for Human Use. Note for Guidance on Good Clinical Practice, Consolidated Guideline. Step 4, Consolidated Guideline, 1/5/96. CPMP/ ICH/135/95.
[10]
Jordan, W.P. and King, S.E. (1977) Delayed Hypersensitivity in Females. The Development of Allergic Contact Dermatitis in Females during the Comparison of Two Predictive Patch Tests. Contact Dermatitis, 3, 19-26. https://doi.org/10.1111/j.1600-0536.1977.tb03582.x
