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糖尿病并发症中MCP-1发病机制及治疗的研究进展
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Abstract:
糖尿病并发症是由于血糖控制不佳，糖尿病(DM)病程延长而导致多组织、多器官的慢性病变，致死致残率极高，严重危害人类健康。研究发现高糖环境下会引起单核细胞趋化蛋白-1 (MCP-1)的上调，使其在糖尿病中引发一系列炎症反应，导致糖尿病并发症的发生。因此了解MCP-1在糖尿病并发症中的发病机制以及了解通过抑制MCP-1治疗糖尿病并发症的研究现状，为积极治疗和有效干预糖尿病并发症的发生发展提供了更多方向。
The complications of diabetes mellitus are chronic lesions of multiple tissues and organs caused by poor blood glucose control and prolonged course of diabetes mellitus (DM), which has a high mortality and disability rate and seriously endangers human health. Studies have found that high glucose environment can lead to the upregulation of monocyte chemotactic protein-1 (MCP-1), which causes a series of inflammatory reactions in diabetes, leading to the occurrence of diabetic complications. Therefore, understanding the pathogenesis of MCP-1 in diabetic complications and the research status of MCP-1 inhibition in the treatment of diabetic complications will provide more directions for active treatment and effective intervention of the occurrence and development of di-abetic complications.
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