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钯基催化制备具有活性基团取代的苯基硼酸
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Abstract:
活性基团取代的苯基硼酸是新型电子材料、医药和农药的重要中间体，其制备研究既具备重要的科学意义，又具备实际的工业生产价值。本文基于Suzuki-Miyaura交叉偶联反应，以活性取代苯为原料，实现了在CH3COOK为碱，[(C6H5)3P]2PdCl2为催化剂的条件下与联硼酸频那醇酯在适宜溶剂协同作用下，获得高收率活性基团取代的苯硼酸频那醇酯，并进一步水解获得对应硼酸化合物，该催化反应特别是对硝基、羰基、酯基的催化效果极好，产品收率可达90%以上。该催化反应是一类优异的准备芳基硼酸衍生物的方法。
Phenylboric acid substituted by active groups is an important intermediate of new electronic materials, medicine and pesticides. Its preparation has important scientific significance and practical industrial production value. In this paper, based on the Suzuka-Miyaura cross-coupling reaction, with active substituted benzene as raw material, under the condition of CH3COOK as base, [(C6H5)3P]2PdCl2 as catalyst and biboratefenalyl ester under the synergic action of suitable solvent, the high yield of active group substituted fenalyl phenyl ester was obtained. The boric acid was further hydrolyzed to obtain the corresponding boric acid compound. The catalytic reaction, especially for nitro group, carbonyl group and ester group, was very good, and the yield of the product could reach more than 90%. This catalytic reaction is an excellent method for preparing arylboric acid derivatives.
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