|
|
氯氮平联合利培酮治疗精神分裂症致粒细胞缺乏1例报告
|
Abstract:
本文介绍了1例氯氮平联合利培酮治疗精神分裂症致患者粒细胞缺乏病例，叙述了其临床表现、辅助检查、治疗经过，结合相关文献，探讨氯氮平、利培酮致患者粒细胞减少、缺乏的风险，以及防范措施。
This paper introduces a case of granulocytopenia caused by clozapine combined with risperidone in the treatment of patients with schizophrenia, describes its clinical manifestations, secondary ex-amination, and treatment process, combined with the relevant literature, to discuss the risk of granulocytopenia caused by clozapine and risperidone, and the preventive measures.
| [1] | 陆明康, 侯希相, 殷美莉, 等. 氯氮平主要副反应的临床分析(附60例报告) [J].中华神经精神科杂志, 1991, 24(2): 71-74. |
| [2] | Claghorn, J., Honigfeld, G., Abuzzahab, F.S., et al. (1987) The Risks and Benefits of Clozapine Versus Chlorpromazine. Journal of Clinical Psychopharmacology, 7, 377-384. https://doi.org/10.1097/00004714-198712000-00002 |
| [3] | 沈渔邨. 精神病学[M]. 第5版. 北京: 人民卫生出版社, 2009: 849. |
| [4] | Subas, E., Alkan, S., Yalcin, S., et al. (2018) Rapid-Onset Agranulocytosis Following the Intro-duction of Clozapine: A Case Report. Klinik Psikofarmakoloji Bulteni, 28, 255. |
| [5] | Honigfeld, G., Arellano, F., Sethi, J., et al. (1998) Reducing Clozapine-Related Morbidity and Mortality: 5 Years of Experience with the Clozaril National Registry. The Journal of Clinical Psychiatry, 59, 3-7. |
| [6] | 侯成业, 梁英. 三种非典型抗精神病药物治疗精神分裂症对白细胞影响的对照研究[J]. 中国冶金工业医学杂志, 2017, 34(5): 499-501. |
| [7] | 卢翠翠, 赵文博, 沈姗, 张文, 沈承武. 药物诱导的粒细胞缺乏症研究进展[J]. 中国现代应用药学, 2021, 38(12): 1524-1528. https://doi.org/10.13748/j.cnki.issn1007-7693.2021.12.021 |
| [8] | Cowan, C. and Oakley, C. (2007) Leukopenia and Neutropenia Induced by Quetiapine. Progress in Neuro-Psycho- pharmacology and Biological Psychiatry, 31, 292-294. https://doi.org/10.1016/j.pnpbp.2006.07.003 |
| [9] | 白茹. 氯氮平引起粒细胞减少或缺乏的预测[J]. 临床精神医学杂志, 2005, 15(6): 365. |
| [10] | 蒲玉春, 阮淑芳. 抗精神分裂药致白细胞减少的调查分析[J]. 深圳中西医结合杂志, 2016, 26(12): 67-69. |
| [11] | 杨健身, 张尉良. 氯氮平与粒细胞缺乏[J]. 上海精神医学杂志, 1990, 新2(4): 189-190. |
