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评估具抗疲劳功效之乳酸菌
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Abstract:
本研究为评估葡萄王生技股份有限公司(Grape King Bio Ltd.)生产之乳酸菌于抗疲劳功效的效果。实验将35只雄性ICR品系小鼠，以随机方式分为7组(n = 5)：空白对照组(Vehicle)、乳酸菌GKJ1、乳酸菌GKK1、乳酸菌GKK3、乳酸菌GKK4、乳酸菌GKEX，以及乳酸菌GKY5。连续喂食约40天不同乳酸菌菌株，并于试验第29至39天，分别进行前肢抓力、运动力竭分析、以及监测运动后血乳酸(lactate)、血尿素氮(blood urea nitrogen, BUN)变化。结果显示，测试之乳酸菌菌株中，以植物乳杆菌(Lactiplantibacillus plantarum) GKK1和短乳酸杆菌(Levilactobacillus brevis) GKEX与Vehicle相比，具有显著提升前肢抓力、运动力竭时间，以及维持较低的运动后血乳酸和血尿氮素。此外，更具显著提升肝脏及肌肉中的肝醣。综观上述结果，植物乳酸杆菌L. plantarum GKK1与短乳酸杆菌L. brevis GKEX具有提升运动耐力及降低运动疲劳指标的潜力，可应用于运动促进相关的保健品开发。
This study was to evaluate the anti-fatigue effects of lactic acid bacteria (LAB) produced by Grape King Bio Ltd. In the experiment, 35 male ICR mice were randomly divided into 7 groups (n = 5): control (Vehicle), LAB GKJ1, GKK1, GKK3, GKK4, GKEX, and GKY5. Different LAB strains were con-tinuously fed for about 40 days. The forelimb grip and the exercise exhaustion were analyzed, as well as the serum lactate and blood urea nitrogen (BUN) after exercise were monitored respectively during the 29th to 39th day of the experiment. The results showed that, among the tested LAB strains, Lactiplantibacillus plantarum GKK1 and Levilactobacillus brevis GKEX significantly im-proved the forelimb grip, time to exhaustion, and maintained lower serum lactate and BUN respec-tively after exercise when compared to the vehicle. In addition, they significantly increased the gly-cogen in the liver and muscles. From the above results, L. plantarum GKK1 and L. brevis GKEX have the potential to improve exercise endurance and reduce exercise fatigue indicators, which can be applied to the development of health care products related to exercise promotion.
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