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不同细胞因子对诱导间充质干细胞在肌腱损伤修复中的研究进展
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Abstract:
肌腱的损伤在运动和工作场所很常见，它与体育活动、反复微创伤、抑制机制功能障碍、退行性改变以及全身或局部皮质类固醇治疗有关，每年全世界数千万人受到影响，外科手术是肌腱损伤的主要治疗方法。不幸的是，超过90%的患者手术修复后肌腱愈合失败，因此，提高肌腱愈合的方法具有很强的临床意义。利用不同谱系的细胞因子的特性，与间充质干细胞共同作用，促进肌腱损伤的修复，是近年来国内外的研究热点。
Tendon injuries are common in sports and the workplace. It is related to physical activity, repeated microtrauma, dysfunction of inhibitory mechanisms, degenerative changes, and systemic or local corticosteroid treatment. Tens of millions of people are affected worldwide every year. Surgery is the main treatment for tendon injury. Unfortunately, tendon healing fails after surgical repair in more than 90% of patients; therefore, methods to improve tendon healing are of strong clinical in-terest. In recent years, the characteristics of cytokines of different lineages and mesenchymal stem cells are used to promote the repair of tendon injury, which is a research hotspot at home and abroad.
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