急进高原缺氧环境对肠黏膜屏障的影响
The Effect of Hypoxia Environment on Intestinal Mucosal Barrier at High Altitude

随着海拔增高，氧分压不断降低，部分人群急进高原时，会出现高原反应，导致机体各个器官之间出现严重的损伤和一系列复杂的病理生理变化。肠道是连接人体和外部环境之间的一个重要器官，也是人体最大的免疫器官，可以有效的阻挡外界的侵害。急进高原缺氧环境下，可以引起肠粘膜屏障受损，导致部分人群进入高原出现胃肠道症状，如腹泻、呕吐等不适反应，严重者可引起全身炎症反应综合征，甚至引起器官衰竭而导致死亡。通过了解胃肠粘膜损伤与急进高原缺氧环境之间的联系有助于了解并缓解高原消化系统症状的发生。
With the increase of altitude, the partial pressure of oxygen continues to decrease. When some peo-ple rush into the plateau, they will experience altitude reaction, leading to serious damage and a series of complex pathophysiological changes among various organs of the body. Intestine is an im-portant organ connecting the human body and the external environment, and it is also the largest immune organ of the human body, which can effectively block external invasion. In the anoxic envi-ronment of high altitude, the intestinal mucosal barrier may be damaged, leading to gastrointesti-nal symptoms of some people entering the plateau, such as diarrhea, vomiting and other uncom-fortable reactions. In severe cases, systemic inflammatory response syndrome may be caused; even organ failure may lead to death. Understanding the relationship between gastrointestinal mucosal injury and hypoxia environment at high altitude is helpful to understand and alleviate the occur-rence of digestive system symptoms at high altitude.