|
H2FPEF评分在射血分数保留型心力衰竭中的应用研究
|
Abstract:
《中国心血管健康与疾病报告2021》指出我国心血管病患病率处于持续上升阶段,每5例死亡中就有2例死于心血管病。而心力衰竭是各种心血管疾病的终末阶段,严重影响了人类的生存质量。其中射血分数保留的心力衰竭(Heart failure with preserved ejection fraction, HFpEF)的占比越来越大。目前关于HFpEF的病理生理机制不明确,诊断及治疗暂无较大突破,但近几年提出H2FPEF评分有助于该疾病的诊断,甚至有研究表明可以预测心血管不良事件的发生。现将H2FPEF评分近几年的研究作一阐述。
China Cardiovascular Health and Disease Report 2021 pointed out that the prevalence of cardio-vascular disease in my country is on the rise, and 2 out of every 5 deaths are due to cardiovascular disease. Heart failure is the terminal stage of various cardiovascular diseases, which seriously af-fects the quality of human life. The proportion of heart failure with preserved ejection fraction (HFpEF) is increasing. At present, the pathophysiological mechanism of HFpEF is unclear, and there has been no major breakthrough in diagnosis and treatment. However, in recent years, it has been proposed that the H2FPEF score is helpful for the diagnosis of the disease, and some studies have even shown that it can predict the occurrence of adverse cardiovascular events. Now, the research on H2FPEF score in recent years will be described.
[1] | McDonagh, T.A., et al. (2022) 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Fail-ure. European Heart Journal, 42, 3599-3726. |
[2] | 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2021概要[J]. 中国循环杂志, 2022, 37(6): 553-578. |
[3] | Reddy, Y.N.V., Carter, R.E., Obokata, M., et al. (2018) A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure with Preserved Ejection Fraction. Circu-lation, 138, 861-870.
https://doi.org/10.1161/CIRCULATIONAHA.118.034646 |
[4] | Paulus, W.J. (2018) H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure with Preserved Ejection Fraction. Circulation, 138, 871-873. https://doi.org/10.1161/CIRCULATIONAHA.118.035711 |
[5] | Sepehrvand, N., Alemayehu, W., Dyck, G.J.B., et al. (2019) External Validation of the H2FPEF Model in Diagnosing Patients with Heart Failure and Preserved Ejection Fraction. Circulation, 139, 2377-2379.
https://doi.org/10.1161/CIRCULATIONAHA.118.038594 |
[6] | Myhre, P., Vaduganathan, M., Claggett, B., et al. (2019) Application of the H2FPEF-Score to a Global Clinical Trial of Patients with Heart Failure with Preserved Ejection Fraction: The TOPCAT Trial. Journal of the American College of Cardiology, 73, 912. https://doi.org/10.1016/S0735-1097(19)31519-0 |
[7] | Parcha, V., Malla, G., Kalra, R., et al. (2020) Diagnostic and Prognostic Implications of Heart Failure with Preserved Ejection Fraction Scoring Systems. ESC Heart Failure, 8, 2089-2102. https://doi.org/10.1002/ehf2.13288 |
[8] | Nikorowitsch, J., Bei Der Kellen, R., Kirchhof, P., et al. (2021) Applying the ESC 2016, the H2FPEF, and the HFA-PEFF Diagnostic Algorithms for Heart Failure with Preserved Ejec-tion Fraction to the General Population—A Comparative Approach. European Heart Journal, 42, ehab724.0856. https://doi.org/10.1093/eurheartj/ehab724.0856 |
[9] | Segar, M.W., Patel, K.V., Berry, J.D., et al. (2019) Generali-zability and Implications of the H2FPEF Score in a Cohort of Patients with Heart Failure with Preserved Ejection Fraction. Circulation, 139, 1851-1853.
https://doi.org/10.1161/CIRCULATIONAHA.118.039051 |
[10] | Takahari, K., Hidaka, T., Ueda, Y., et al. (2019) H2FPEF Score for the Prediction of Exercise Intolerance and Abnormal Hemodynamics in Japanese. Circulation Journal, 83, 2487-2493. https://doi.org/10.1253/circj.CJ-19-0699 |
[11] | Tada, A., Nagai, T., Omote, K., et al. (2021) Perfor-mance of the H2FPEF and the HFA-PEFF Scores for the Diagnosis of Heart Failure with Preserved Ejection Fraction in Japanese Patients: A Report from the Japanese Multicenter Registry. International Journal of Cardiology, 342, 43-48. https://doi.org/10.1016/j.ijcard.2021.08.001 |
[12] | 刘秋颖, 张云山, 王璐璐. 左室舒张功能不全分级与临床H2FPEF评分诊断HFpEF的比较研究[J]. 中国超声医学杂志, 2022, 38(5): 529-532. |
[13] | Louise, S., Anna, B., Fernando, T., et al. (2019) Inclusion of Left Atrial Strain Evaluation with the “H2FPEF Score” Enhances Diagnostic Ac-curacy for Heart Failure with Preserved Ejection Fraction. Journal of the American College of Cardiology, 73, 800. https://doi.org/10.1016/S0735-1097(19)31407-X |
[14] | Withaar, C., Lam, C.S.P., Schiattarella, G.G., et al. (2021) Heart Failure with Preserved Ejection Fraction in Humans and Mice: Embracing Clinical Complexity in Mouse Models. European Heart Journal, 42, 4420-4430.
https://doi.org/10.1093/eurheartj/ehab389 |
[15] | Obokata, M. and Borlaug, B.A. (2018) The Strengths and Limita-tions of E/e’ in Heart Failure with Preserved Ejection Fraction. European Journal of Heart Failure, 20, 1312-1314. https://doi.org/10.1002/ejhf.1250 |
[16] | Sharifov, O.F., Schiros, C.G., Aban, I., et al. (2016) Diagnostic Accuracy of Tissue Doppler Index E/e’ for Evaluating Left Ventricular Filling Pressure and Diastolic Dysfunction/Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Journal of the American Heart Association, 5, e002530.
https://doi.org/10.1161/JAHA.115.002530 |
[17] | Fisher, M.R., Forfia, P.R., Chamera, E., et al. (2009) Accuracy of Doppler Echocardiography in the Hemodynamic Assessment of Pulmonary Hypertension. American Journal of Respir-atory and Critical Care Medicine, 179, 615-621.
https://doi.org/10.1164/rccm.200811-1691OC |
[18] | D’Alto, M., Romeo, E., Argiento, P., et al. (2013) Accuracy and Precision of Echocardiography versus Right Heart Catheterization for the Assessment of Pulmonary Hypertension. International Journal of Cardiology, 168, 4058-4062.
https://doi.org/10.1016/j.ijcard.2013.07.005 |
[19] | Pitt, B., Pfeffer, M.A., Assmann, S.F., et al. (2014) Spironolac-tone for Heart Failure with Preserved Ejection Fraction. The New England Journal of Medicine, 370, 1383-1392. https://doi.org/10.1056/NEJMoa1313731 |
[20] | Sueta, D., Yamamoto, E., Nishihara, T., et al. (2019) H2FPEF Score as a Prognostic Value in HFpEF Patients. American Journal of Hypertension, 32, 1082-1090. https://doi.org/10.1093/ajh/hpz108 |
[21] | Senthil, S., Peder, L.M., Muthiah, V., et al. (2020) Application of Diag-nostic Algorithms for Heart Failure with Preserved Ejection Fraction to the Community. JACC: Heart Failure, 8, 640-653.
https://doi.org/10.1016/j.jchf.2020.04.005 |
[22] | Przewlocka-Kosmala, M., Marwick, T.H., Jankowska, E.A., et al. (2019) P1639 Prognostic Utility of H2FPEF Score in Heart Failure with Preserved Ejection Fraction. European Heart Journal, 40, ehz748.0398.
https://doi.org/10.1093/eurheartj/ehz748.0398 |
[23] | Sun, Y., Wang, N., Li, X., et al. (2021) Predictive Value of H2FPEF Score in Patients with Heart Failure with Preserved Ejection Fraction. ESC Heart Failure, 8, 1244-1252. https://doi.org/10.1002/ehf2.13187 |
[24] | Tao, Y., Wang, W., Zhu, J., et al. (2021) H2FPEF Score Predicts 1-Year Rehospitalisation of Patients with Heart Failure with Preserved Ejection Fraction. Postgraduate Medical Journal, 97, 164-167.
https://doi.org/10.1136/postgradmedj-2019-137434 |
[25] | Kap?on-Cie?licka, A., Kupczyńska, K., Dobrowolski, P., et al. (2020) On the Search for the Right Definition of Heart Failure with Preserved Ejection Fraction. Cardiology Jour-nal, 27, 449-468. https://doi.org/10.5603/CJ.a2020.0124 |
[26] | Suzuki, S., Kaikita, K., Yamamoto, E., et al. (2020) H2FPEF Score for Predicting Future Heart Failure in Stable Outpatients with Cardiovascular Risk Factors. ESC Heart Failure, 7, 66-75. https://doi.org/10.1002/ehf2.12570 |
[27] | In-Chang, H., Goo-Yeong, C., Hong-Mi, C., et al. (2020) H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients with Heart Failure with Preserved Ejection Fraction. Journal of Cardiac Failure, 27, 198-207.
https://doi.org/10.1016/j.cardfail.2020.09.474 |
[28] | Verbrugge, F.H., Reddy, Y.N.V., Sorimachi, H., et al. (2021) Diagnostic Scores Predict Morbidity and Mortality in Patients Hospitalized for Heart Failure with Preserved Ejection Fraction. European Journal of Heart Failure, 23, 954-963.
https://doi.org/10.1002/ejhf.2142 |
[29] | Huang, W.M., Cheng, H.M., Yu, W.C., et al. (2020) The Ventilatory Ab-normalities and Prognostic Values of H2FPEF Score in Dyspnoeic Patients with Preserved Left Ventricle Systolic Func-tion. ESC Heart Failure, 7, 1872-1879.
https://doi.org/10.1002/ehf2.12754 |
[30] | Amanai, S., Harada, T., Kagami, K., et al. (2022) The H2FPEF and HFA-PEFF Algorithms for Predicting Exercise Intolerance and Abnormal Hemodynamics in Heart Failure with Pre-served Ejection Fraction. Scientific Reports, 12, Article No. 13. https://doi.org/10.1038/s41598-021-03974-6 |
[31] | Ludwig, S., Pellegrini, C., Gossling, A., et al. (2020) Prognostic Value of the H2FPEF Score in Patients Undergoing Transcatheter Aortic Valve Implantation. ESC Heart Failure, 8, 461-470. https://doi.org/10.1002/ehf2.13096 |
[32] | Ludwig, S., Voigtlaender, L., Ruebsamen, N., et al. (2019) High H2FPEF Score Is an Independent Predictor of Adverse Outcome in Patients with Severe Aortic Stenosis and Preserved Ejection Fraction Undergoing TAVR. European Heart Journal, 40, ehz745.0696. https://doi.org/10.1093/eurheartj/ehz745.0696 |
[33] | Miyasaka, Y., Taniguchi, N., Suwa, Y., et al. (2020) Useful-ness of H2FPEF Score as an Independent Predictor of Heart Failure Development in Patients with Atrial Fibrillation. Eu-ropean Heart Journal, 41, ehaa946.0532.
https://doi.org/10.1093/ehjci/ehaa946.0532 |
[34] | Somerville, C., Gong, F.F., et al. (2020) Association of the H2FPEF Risk Score with Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation. Journal of Atrial Fibril-lation, 12, Article No. 2295.
https://doi.org/10.4022/jafib.2295 |