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循环肿瘤细胞在食管癌治疗中的研究进展
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Abstract:
食管腺癌(EC)是一种高度侵袭性的癌症，通常在晚期被诊断出来。近年来，其发病率大幅增加，迫切需要新的诊断、预后和预测性生物标志物。CTC是从原发性或转移性肿瘤脱落到外周循环中的细胞。大多数CTC将被人体免疫系统清除，而少数幸存的CTC可以通过血液到达身体的其他部位，导致肿瘤转移。初步研究结果表明，CTC在EC的所有阶段都可以代表一种有效的、非侵入性的、实时可评估的生物标志物。本文将对目前CTC在食管癌中的应用进行总结，以确认CTC的临床有用性。
Esophageal adenocarcinoma (EC) is a highly aggressive cancer that is usually diagnosed at an ad-vanced stage. Its incidence has increased dramatically in recent years, and new diagnostic, prog-nostic and predictive biomarkers are urgently needed. CTCs are cells shed into the peripheral cir-culation from primary or metastatic tumors. Most CTCs will be cleared by the body’s immune sys-tem, while the few that survive can travel through the bloodstream to other parts of the body, caus-ing tumors to metastasize. Preliminary findings suggest that CTCs can represent an effective, non-invasive, and real-time evaluable biomarker in all stages of EC. This article will summarize the cur-rent application of CTCs in esophageal cancer to confirm the clinical usefulness of CTCs.
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