Hashimoto’s disease is a condition that occurs
when an affected person’s immune system
attacks their thyroid gland and produces an immune response that results
in low levels of thyroid hormones in the blood. These hormones are important in
maintaining the body’s metabolic processes and the lack of thyroid hormones
causes the symptoms of Hashimoto’s disease that
include weight gain, paleness, coldness, birth defect, infertility,
menorrhagia, and even death in rare cases of uncontrolled hypothyroidism. The
disease requires a blood test to determine the levels of circulating thyroid
hormones in the blood or the presence of specific antibodies. Thyroid hormone
replacement is used to raise the levels of thyroid hormones in the body, if the
hormone test shows that they are deficient. People who are middle aged, female,
and have or are predisposed to an autoimmune disorder are most at risk for
developing the disease. In recent times, the notion that the antidote for
managing Hashimoto’s disease may be found in common food and supplements has
grown among endocrinologists and caregivers. This review is intended to
investigate the various aspects of the disease that include its pathogenesis,
associated disorders, pharmacological and nutritional interventions.
References
[1]
Hashimoto’s Disease—A Frame Diagram. Self Design.
[2]
Hashimoto, H. (1912) Zur Kenntniss der Lyphomatosen Verandererung Schilddruse (Struma lymphomatosa). Arch Klin Chirugie, 972, Article No. 219.
[3]
Dunkin, M.A. (2020) Hashimoto’s Thyroiditis: Symptoms, Causes, and Treatments. https://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments
[4]
Bancos, I. (2018) Thyroid and Parathyroid Hormones. Endocrine Society. https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/thyroid-and-parathyroid-hormones
[5]
Diagram of the Thyroid Gland (n.d.) Enliven Wellness. https://www.enlivenwv.com/hashimotos-thyroid
[6]
U.S. Department of Health and Human Services (2018) Hashimoto’s Disease. National Institute of Diabetes and Digestive and Kidney Diseases.
[7]
LDNscience-MedInsight Research Institute (2022) Hashimoto’s Symptoms. https://10faq.com/health/hashimotos-disease-symptoms
[8]
Kat. (2019) Hashimoto’s Symptoms Checklist. Tons of Goodness. https://tonsofgoodness.com/my-experience-with-hashimotos-symptoms-diagnosis-and-treatment
[9]
Gard, R.P. (2005) Human Endocrinology. Taylor & Francis Ltd., Arbingdon, Oxon, 50-55.
[10]
Nazario, B. (2021) Goiter. WebMD. https://www.webmd.com/women/understanding-goiter-basics
[11]
Hormone (2021) Thyroid Hormones. Hormone Health Network. https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/thyroid-hormones
[12]
Davis, L.E., Leveno, K.J. and Cunningham, F.G. (1988) Hypothyroidism Complicating Pregnancy. Obstetrics and Gynecology, 72, 108-112.
[13]
Mizgala, L., Lao, T.T. and Hannah, M.E. (1991) Hypothyroidism Presenting as Hypothermia Following Pre-Eclampsia at 23 Weeks Gestation. British Journal of Obstetrics and Gynaecology, 98, 221-224. https://doi.org/10.1111/j.1471-0528.1991.tb13374.x
[14]
Leung, A.S., Millar, L.K., Koonings, P.F., Montoro, M. and Mestman, J. (1993) Pernatal Outcome in Hypothyroid Pregnancies. Obstetrics and Gynecology, 81, 349-353.
[15]
Abalovich, M., Gutierrez, S., Alcaraz, G., Maccallini, G., Garcia, A. and Levalle, O. (2002) Overt and Subclinical Hypothyroidism Complicating Pregnancy. Thyroid, 12, 63-68. https://doi.org/10.1089/105072502753451986
[16]
Glinoer, D., Rihi, M., Grun, J.F. and Kinthaert, J. (1994) Risk of Subclinical Hypothyroidism in Pregnant Women with Asymptomatic Thyroid Disorders. The Journal of Clinical Endocrinology and Metabolism, 79, 197-204. https://doi.org/10.1210/jcem.79.1.8027226
[17]
Casey, B.M., Dashe, J.S., Wells, C.E., McIntire, D.D., Byrd, W., Leveno, K.J. and Cunningham, F.G. (2005) Suclinical Hypothyroidism Is Associated with Premature Delivery. Obstetrics and Gynecology, 105, 239-245. https://doi.org/10.1097/01.AOG.0000152345.99421.22
[18]
Ruggeri, R.M., Trimarchi, F., Guiffrida, G., et al. (2017) Autoimmune Comorbidities in Hashimoto’s Thyroiditis: Different Patterns of Association in Adulthood and Childhood and Childhood/Adolescence. European Journal of Endocrinology, 176, 133-141. https://doi.org/10.1530/EJE-16-0737
[19]
Control of Endocrine Activity (n.d.) Vivo Pathophysiology. http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/basics/control.html#:~:text=When%20blood%20concentrations%20of%20thyroid,example%20of%20%22negative%20feedback%22
[20]
Arrangoiz, R., Cordera, F., Caba, D., et al. (2018) Comprehensive Review of Thyroid Embryology, Anatomy, Histology, and Physiology for Surgeons. International Journal of Otolaryngology and Head & Neck Surgery, 7, 160-188. https://www.researchgate.net/figure/Hypothalamic-pituitary-thyroid-axis_fig10_326375395
[21]
Shira, E. (2022) Do I Have Hashimoto’ Disease (Thyroiditis). https://endocrineWeb.com/conditions/hashimoto’s-thyroiditis
[22]
Ajjan, R.A. and Weetman, A.P. (2015) The Pathogenesis of Hashimoto’s Thyroiditis: Further Develops in Our Understanding. Hormone and Metabolic Research, 47 702-710. https://doi.org/10.1055/s-0035-1548832
[23]
Weetman, A.P. (2005) Non-Thyroid Autoantibodies in Autoimmune Thyroid Disease. Best Practice & Research Clinical Endocrinology & Metabolism, 19, 17-32. https://doi.org/10.1016/j.beem.2004.11.004
[24]
Penta, L., Cofini, M., Lanciotti, L., Leonardi, A., Principi, N. and Esposito, S. (2018) Hashimoto Disease and Thyroid Cancer in Children: Are They Associated? Frontiers in Endocrinology (Lausanne), 9, 565. https://doi.org/10.3389/fendo.2018.00565
[25]
Mayo Foundation for Medical Education and Research (2020) Hypothyroidism (Underactive Thyroid). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/hypothyroidism/symptoms-causes/syc-20350284
[26]
Ragusa, F., Fallahi, P., Elia, G., et al. (2019) Hashimotos’ Thyroiditis: Epidemiology, Pathogenesis, Clinic, and Therapy. Best Practice & Research Clinical Endocrinology & Metabolism, 33, Article ID: 101367. https://doi.org/10.1016/j.beem.2019.101367
[27]
Mayo Foundation for Medical Education and Research (2020) Hashimoto’s Disease. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/hashimotos-disease/diagnosis-treatment/drc-20351860
[28]
Maeda, S.S., Fortes, E.M., Oliveira, U.M., Borba, V.C. and Lazaretti-Castro, M. (2006) Hypoparathyroidism and Pseudohypoparathyroidism. Arquivos Brasileiros de Endocrinologia & Metabologia, 50, 664-673. https://doi.org/10.1590/S0004-27302006000400012
[29]
Bollerslev, J., Rejnmark, L., Marcocci, C., Shoback, D.M., Sitges-Serra, A., van Biesen, W., et al. (2015) European Society of Endocrinology Clinical Guideline: Treatment of Chronic Hypoparathyroidism in Adults. European Journal of Endocrinology, 173, G1-G20. https://doi.org/10.1530/EJE-15-0628
[30]
Shoback, D. (2008) Clinical Practice. Hypoparathyroidism. New England Journal of Medicine, 359, 391-403. https://doi.org/10.1056/NEJMcp0803050
[31]
Clarke, B.L., Brown, E.M., Collins, M.T., Juppner, H., Lakatos, P., Levine, M.A., et al. (2016) Epidemiology and Diagnosis of Hypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism, 101, 2284-2299. https://doi.org/10.1210/jc.2015-3908
[32]
Sergio, S.M., Marise, L.-C., et al. (2018) Diagnosis and Treatment of Hypothyroidism: A Position Statement from the Brazilian Society of Endocrinology and Metabolism. Archives of Endocrinology and Metabolism, 62, 106-124.
[33]
Morris, E.D., Stuart, L. and Richard, S. (1995) Relation of Thyroid Neoplasms to Hashimoto Disease of the Thyroid Gland. American Medical Association Archives of Surgery, 70, 291-297. https://doi.org/10.1001/archsurg.1955.01270080137023
[34]
Kilfoy, B., Zheng, T., Holford, T., et al. (2009) International Patterns and Trends in Thyroid Cancer Incidence, 1973-2002. Cancer Causes and Control, 20, 525-531. https://doi.org/10.1007/s10552-008-9260-4
[35]
Norman, J. and Kopf, J. (2021) What Is Hypothyroidism? Endocrine Web. https://www.endocrineweb.com/conditions/hypothyroidism
[36]
Plexus Professional Network Private Limited (2021) A Third Discontinuing Levothyroxine Have Normal Thyroid Levels. Plexus MD. https://www.plexusmd.com/md/post/a-third-discontinuing-levothyroxine-have/64073
Roberto, N., Gianni, F., Tiziana, M., Antonio, P., Davide, D. and Haslinda, H. (2006) Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications. The Journal of Clinical Endocrinology & Metabolism, 91, 2587-2591. https://doi.org/10.1210/jc.2005-1603
[41]
Toulis, K.A., Anthanasios, D.A., Thrasivoulos, G.T., Dimitrios, G.G. and Kouvelas, D. (2010) Selenium Supplementation in the Treatment of Hashimoto’s Thyroiditis: A Systematic Review and a Meta-Analysis. Thyroid, 20, 1163-1173.
[42]
Yana, D., Tsevetelina, V., Georgi, N., Zorka, M., Alexander, S., Hristo, G. and Rossitza, K. (2022) Nutritional Management of Thyroiditis of Hashimoto. International Journal of Molecular Sciences, 23, Article No. 5144. https://doi.org/10.3390/ijms23095144
[43]
Carmen, S. (2017) Reactive Oxygen Species and Antioxidant Properties from Mushrooms. Synthetic and Systems Biotechnology, 2, 13-22. https://doi.org/10.1016/j.synbio.2016.12.001
[44]
Di Lorenzo, C., Dell’agli, M., Badea, M., Lorena, D., et al. (2013) Plant Food Supplements with Anti-Inflammatory Properties: A Systematic Review (II). Critical Reviews in Food Science and Nutrition, 53, 507-516.
[45]
U.S. Department of Health and Human Services (2021) Graves’ Disease. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/endocrine-diseases/graves-disease
[46]
Mayo Foundation for Medical Education and Research (2022) Thyroid Nodules. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/thyroid-nodules/symptoms-causes/syc-20355262#:~:text=Thyroid%20nodules%20are%20solid%20or,of%20thyroid%20nodules%20are%20cancerous