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Does Haptoglobin Phenotype Impact Infection Mortality?

DOI: 10.4236/abc.2022.125012, PP. 143-150

Keywords: HIV/AIDS Infection, Phenotype of Haptoglobin, CD4+ Cell Counts, Hemoglobin, Mortality

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Introduction: The physiological status of a subject and the pathophysiology in some diseases might be under the influence of haptoglobin phenotype. The objective of this work was to determine the relationship between mortality from HIV/AIDS infection and haptoglobin phenotype in a black population in Côte d’Ivoire. Methods: The study was conducted from a retrospective panel of 933 sera/plasma from the previous workup of the ANRS 12136 TEMPRANO trial at month 0 of patients in deferred-ART arms. For each subject, we determined the serum haptoglobin concentration, haptoglobin phenotype, and other variables from patient files from the TEMPRANO trial database. Statistical tests used were Chi-2, Fischer, and Kruskal-Wallis tests for non-gaussian distribution. We used the Kaplan-Meier method for survival analysis. Results: The distributions of the haptoglobin phenotypes were 32.3% for Hp 1-1, 39.5% for Hp 2-1 and 27.2% for Hp 2-2. The blood haptoglobin concentration seemed to be associated with haptoglobin phenotypes (p-value > 5%). The survival rate at M30 and for an extended follow-up up to 6 years was independent of haptoglobin phenotype (p-value > 5%). Besides, the haptoglobin phenotypes do not appear to be associated with CD4+ T-cell count and with hemoglobin concentration. Conclusion: Haptoglobin phenotype seems to not impact the mortality of HIV/AIDS infection. However, given the antioxidant and immunomodulatory properties of some haptoglobin phenotypes, it would be relevant to seek out possible confounding factors indirectly associated with haptoglobin phenotypes and clinical or biological infection variables.


[1]  Di Masi, A., De Simone, G., Ciaccio, C., D’Orso, S., Coletta, M. and Ascenzi, P. (2020) Haptoglobin: From Hemoglobin Scavenging to Human Health. Molecular Aspects of Medicine, 73, Article ID: 100851.
[2]  Yousif, A.S. and Elagib, A.A. (2017) Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan. Mediterranean Journal of Hematology and Infectious Diseases, 9, e2017042.
[3]  Andersen, C.B.F., Stødkilde, K., Sæderup, K.L., Kuhlee, A., Raunser, S., Graversen, J.H., et al. (2017) Haptoglobin. Antioxidants & Redox Signaling, 26, 814-831.
[4]  Tal, S., Adir, Y., Stein, N., Shalom, H., Lache, O., Levy, A., et al. (2019) COPD Exacerbator Phenotype Is Inversely Associated with Current Smoking but Not with Haptoglobin Phenotype. The Israel Medical Association Journal, 21, 19-23.
[5]  Beeri, M.S., Lin, H.M., Sano, M., Ravona-Springer, R., Liu, X., Bendlin, B.B., et al. (2018) Association of the Haptoglobin Gene Polymorphism with Cognitive Function and Decline in Elderly African American Adults with Type 2 Diabetes: Findings from the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Study. JAMA Network Open, 1, e184458.
[6]  Awasthi, G., Tyagi, S., Kumar, V., Patel, S.K., Rojh, D., Sakrappanavar, V., et al. (2018) A Proteogenomic Analysis of Haptoglobin in Malaria. Proteomics-Clinical Applications, 12, Article ID: 1700077.
[7]  By, P., Ahiboh, H.T., Koffi, J.A.S., Koné, F., Touré, H., Traoré, M., et al. (2017) Haptoglobin Phenotype and Soluble Transferrin Receptor among Tuberculosis. Journal of Advances in Medicine and Medical Research, 19, 1-7.
[8]  The TEMPRANO ANRS 12136 Study Group (2015) A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa. New England Journal of Medicine, 373, 808-822.
[9]  World Health Organization (2010) Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach—2010 Revision.
[10]  Peacock, A.C., Bunting, S.L. and Queen, K.G. (1965) Serum Protein Electrophoresis in Acrylamide Gel: Patterns from Normal Human Subjects. Science, 147, 1451-1453.
[11]  Raymond, S. (1962) A Convenient Apparatus for Vertical Gel Electrophoresis. Clinical Chemistry, 8, 455-470.
[12]  Scully, E.P. (2018) Sex Differences in HIV Infection. Current HIV/AIDS Reports, 15, 136-146.
[13]  Tibbels, N.J., Hendrickson, Z.M., Naugle, D.A., Dosso, A., Van Lith, L., Mallalieu, E.C., et al. (2019) Men’s Perceptions of HIV Care Engagement at the Facility- and Provider-Levels: Experiences in Cote d’Ivoire. PLOS ONE, 14, e0211385.
[14]  AIDSinfo UNAIDS (2022).
[15]  Côte d’Ivoire (2022).
[16]  Bamm, V.V., Geist, A.M. and Harauz, G. (2017) Correlation of Geographic Distributions of Haptoglobin Alleles with Prevalence of Multiple Sclerosis (MS)—A Narrative Literature Review. Metabolic Brain Disease, 32, 19-34.
[17]  Zaccariotto, T.R., Rosim, E.T., Melo, D., Garcia, P.M.D., Munhoz, R.R., Aoki, F.H., et al. (2006) Haptoglobin Polymorphism in a HIV-1 Seropositive Brazilian Population. Journal of Clinical Pathology, 59, 550-553.
[18]  Smeets, M.B., Pasterkamp, G., Lim, S.K., Velema, E., Van Middelaar, B. and De Kleijn, D.P.V. (2002) Nitric Oxide Synthesis Is Involved in Arterial Haptoglobin Expression after Sustained Flow Changes. FEBS Letters, 529, 221-224.
[19]  Wang, Y., Kinzie, E., Berger, F.G., Lim, S.K. and Baumann, H. (2001) Haptoglobin, an Inflammation-Inducible Plasma Protein. Redox Report, 6, 79-85.
[20]  Yang, F., Ghio, A.J., Herbert, D.C., Weaker, F.J., Walter, C.A. and Coalson, J.J. (2000) Pulmonary Expression of the Human Haptoglobin Gene. American Journal of Respiratory Cell and Molecular, 23, 277-282.
[21]  Oh, M.K., Park, H.J., Kim, N.H., Park, S.J., Park, I.Y. and Kim, I.S. (2011) Hypoxia-Inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter. Journal of Biological Chemistry, 286, 8857-8565.
[22]  Do Nascimento, C.O., Hunter, L. and Trayhurn, P. (2004) Regulation of Haptoglobin Gene Expression in 3T3-L1 Adipocytes by Cytokines, Catecholamines, and PPARγ. Biochemical and Biophysical Research Communications, 313, 702-708.
[23]  Delanghe, J.R., Langlois, M.R., Boelaert, J.R., Van Acker, J., Van Wanzeele, F., Van Der Groen, G., et al. (1998) Haptoglobin Polymorphism, Iron Metabolism and Mortality in HIV Infection. AIDS, 12, 1027-1032.


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