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姜黄素药理作用及机制研究进展
Research Progress on Pharmacological Action and Mechanism of Curcumin

DOI: 10.12677/ACM.2022.1291181, PP. 8195-8201

Keywords: 姜黄素,药理作用,研究进展
Curcumin
, Pharmacological Action, Research Progress

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Abstract:

姜黄素(Curcumin)属于一类多酚类化合物,其来源为姜黄(属于姜科)的根茎。此物质是姜黄释放自身药理活性的主要成分。药理实验已明确姜黄素可有效抗肿瘤、抗氧化与抗炎等,且毒性小,安全性高,具有高度临床推广价值。现综述姜黄素药理研究进展,希望为其临床应用及进一步研究提供新思路。
Curcumin belongs to a class of polyphenol compounds, and its source is the rhizome of turmeric (belonging to Zingiberaceae). This substance is the main component of turmeric releasing its own pharmacological activity. Pharmacological experiments have confirmed that it can effectively resist tumor, oxidation and anti-inflammatory, with low toxicity and high safety. It has high clinical pro-motion value. This paper reviews the pharmacological research progress of curcumin, hoping to provide new ideas for its clinical application and further research.

References

[1]  Anand, P., Kunnumakkara, A.B., Newman, R.A. and Aggarwal, B.B. (2007) Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics, 4, 807-818.
https://doi.org/10.1021/mp700113r
[2]  刘伟, 顾秀竹, 吴筱霓, 何玉华. 姜黄素药理作用的研究进展[J]. 华西药学杂志, 2021, 36(3): 336-340.
[3]  Khopde, S.M., Priyadarsini, K.I., Palit, D.K. and Mukherjee, T. (2000) Effect of Solvent on the Excited-State Photophysical Properties of Curcumin. Photochemistry and Photobiology, 72, 625-631.
https://doi.org/10.1562/0031-8655(2000)072<0625:EOSOTE>2.0.CO;2
[4]  Selvam, C., Jachak, S.M., Thilaga-vathi, R. and Chakraborti, A.K. (2005) Design, Synthesis, Biological Evaluation and Molecular Docking of Curcumin Analogues as Antioxidant, Cyclooxygenase Inhibitory and Anti-Inflammatory Agents. Bioorganic & Medicinal Chemis-try Letters, 15, 1793-1797.
https://doi.org/10.1016/j.bmcl.2005.02.039
[5]  Menon, L.G., Kuttan, R. and Kuttan, G. (1995) Inhibition of Lung Metastasis in Mice Induced by B16F10 Melanoma Cells by Polyphenolic Compounds. Cancer Letters, 95, 221-225.
https://doi.org/10.1016/0304-3835(95)03887-3
[6]  Nautiyal, J., Banerjee, S., Kanwar, S.S., et al. (2011) Curcumin Enhances Dasatinib-Induced Inhibition of Growth and Transformation of Colon Cancer Cells. In-ternational Journal of Cancer, 128, 951-961.
https://doi.org/10.1002/ijc.25410
[7]  Aggarwal, B.B. and Sung, B. (2009) Pharmacological Basis for the Role of Curcumin in Chronic Diseases: An Age-Old Spice with Modern Targets. Trends in Pharmacological Sciences, 30, 85-94.
https://doi.org/10.1016/j.tips.2008.11.002
[8]  谢永进, 魏斌, 陈跃达, 等. 姜黄素治疗小鼠肝癌移植瘤的实验研究[J]. 中医药通报, 2015, 14(2): 66-69+72.
[9]  郭立达, 焦振霞, 宋瑛, 滕文华, 刘钊, 刘敬泽. 姜黄素诱导结肠癌LoVo细胞凋亡的作用及机制研究[J]. 中国中药杂志, 2013, 38(13): 2191-2196.
[10]  魏民, 张阳德, 何剪太. 姜黄素逆转肝癌耐药性实验研究[J]. 中国现代医学杂志, 2008(17): 2441-2443+2448.
[11]  Menon, V.P. and Sudheer, A.R. (2007) Antioxidant and Anti-Inflammatory Properties of Curcumin. Advances in Experimental Medicine and Biology, 595, 105-125.
https://doi.org/10.1007/978-0-387-46401-5_3
[12]  Ghosh, S., Banerjee, S. and Sil, P.C. (2015) The Beneficial Role of Curcumin on Inflammation, Diabetes and Neurodegenerative Disease: A Recent Update. Food and Chemical Toxicology, 83, 111-124.
https://doi.org/10.1016/j.fct.2015.05.022
[13]  杨丽敏, 魏巍, 刘璐, 陈志海, 张钰. 姜黄素通过长链非编码RNA NNT-AS1降低LPS诱导的支气管上皮细胞炎症因子表达[J]. 华中科技大学学报(医学版), 2022, 51(1): 25-30.
[14]  Arulselvan, P., Fard, M.T., Tan, W.S., et al. (2016) Role of Antioxidants and Natural Products in Inflamma-tion. Oxidative Medicine and Cellular Longevity, 2016, Article ID: 5276130.
https://doi.org/10.1155/2016/5276130
[15]  李超, 贾茜, 袁晓环, 李琳. 姜黄素及其类似物H8对LPS诱导的单核巨噬细胞中炎症因子表达的影响[J]. 牡丹江医学院学报, 2021, 42(4): 16-18+50.
[16]  Quiles, J.L., Mesa, M.D., Ramirez-Tortosa, C.L., et al. (2002) Curcuma Longa Extract Supplementation Reduces Oxidative Stress and At-tenuates Aortic Fatty Streak Development in Rabbits. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1225-1231.
https://doi.org/10.1161/01.ATV.0000020676.11586.F2
[17]  Trush, M.A. and Kensler, T.W. (1991) An Overview of the Relationship between Oxidative Stress and Chemical Carcinogenesis. Free Radical Biology & Medi-cine, 10, 201-209.
https://doi.org/10.1016/0891-5849(91)90077-G
[18]  李瑞华. 姜黄素对牛乳腺上皮细胞的抗氧化作用及抑癌机制的研究[D]: [硕士学位论文]. 长春: 吉林大学, 2021.
[19]  Anand, P., Thomas, S., Kunnumak-kara, A.B., et al. (2008) Biological Activities of Curcumin and Its Analogues (Congeners) Made by Man and Mother Nature. Biochemical Pharmacology, 76, 1590-1611.
https://doi.org/10.1016/j.bcp.2008.08.008
[20]  Ravindran, J., Subbaraju, G.V., Ramani, M.V., Sung, B. and Ag-garwal, B.B. (2010) Bisdemethylcurcumin and Structurally Related Hispolon Analogues of Curcumin Exhibit Enhanced Prooxidant, Anti-Proliferative and Anti-Inflammatory Activities in Vitro. Biochemical Pharmacology, 79, 1658-1666.
https://doi.org/10.1016/j.bcp.2010.01.033
[21]  崔冬月, 李媛媛, 肖宝平, 等. 姜黄素抗氧化的初步机理研究[J]. 食品安全导刊, 2019(20): 68-72.
[22]  Maria, A., Bourgier, C., Martinaud, C., et al. (2020) From Fibrogenesis to-wards Fibrosis: Pathophysiological Mechanisms and Clinical Presentations. La Revue de Médecine Interne, 41, 325-329.
https://doi.org/10.1016/j.revmed.2020.01.002
[23]  李银生, 牛建昭, 王继峰, 周刚, 杨美娟. 姜黄素对肺纤维化大鼠肺组织胶原沉积及转化生长因子β1表达的影响[J]. 中华中医药学刊, 2007(1): 55-57.
[24]  宋健, 刘莉君, 孙守才. 姜黄素对肝纤维化大鼠肝组织I, III, IV型胶原的影响[J]. 时珍国医国药, 2009, 20(4): 933-935.
[25]  丁秀娟, 刘百奇, 王灵君, 孟祥龙, 韩健. 姜黄素对冠状动脉粥样硬化危险因素的影响[J]. 中国医药指南, 2020, 18(17): 39-40.
[26]  Arafa, H.M. (2005) Curcumin Attenuates Diet-Induced Hypercholesterolemia in Rats. Medical Sci-ence Monitor, 11, BR228-BR234.
[27]  沃兴德, 洪行球, 赵革平, 唐利华. 姜黄素对低密度脂蛋白和脂蛋白(a)代谢的影响[J]. 中国动脉硬化杂志, 1999(4): 339-341.
[28]  邱敏, 黄超龙. 姜黄素对兔心肌缺血再灌注损伤的影响[J]. 数理医药学杂志, 2011, 24(5): 578-579.
[29]  Um, M.Y., Hwang, K.H., Choi, W.H., Ahn, J., Jung, C.H. and Ha, T.Y. (2014) Curcumin Attenuates Adhesion Molecules and Matrix Metalloproteinase Expression in Hypercholester-olemic Rabbits. Nutrition Research, 34, 886-893.
https://doi.org/10.1016/j.nutres.2014.09.001
[30]  Pfeffer, M.A. and Braunwald, E. (1990) Ventricular Remodeling after Myocardial Infarction. Experimental Observations and Clinical Implications. Circulation, 81, 1161-1172.
https://doi.org/10.1161/01.CIR.81.4.1161
[31]  Wang, N.P., Wang, Z.F., Tootle, S., Philip, T. and Zhao, Z.Q. (2012) Curcumin Promotes Cardiac Repair and Ameliorates Cardiac Dysfunction Following Myocardial Infarction. British Journal of Pharmacology, 167, 1550-1562.
https://doi.org/10.1111/j.1476-5381.2012.02109.x
[32]  Assis, R.P., Arcaro, C.A., Gutierres, V.O., et al. (2017) Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. International Journal of Molecular Sciences, 18, Article No. 332.
https://doi.org/10.3390/ijms18040332
[33]  Karuppagounder, V., Arumugam, S., Giridharan, V.V., et al. (2017) Tiny Molecule, Big Power: Multi-Target Approach for Curcumin in Diabetic Cardiomyopathy. Nutrition, 34, 47-54.
https://doi.org/10.1016/j.nut.2016.09.005
[34]  潘建萍, 何春明, 钟禹霖, 黄丽芸. 姜黄素和胡椒碱复方改善大鼠抑郁症的机制[J]. 中国药物经济学, 2020, 15(7): 45-48.
[35]  薄秀梅, 贺玲, 张荣丽, 杜赛君, 徐洲. 姜黄素对脂多糖诱导的小鼠抑郁样行为的影响及机制[J]. 安徽医科大学学报, 2020, 55(7): 1064-1068.
[36]  吕慧君. 姜黄素通过激活Wnt/β-catenin通路对6-OHDA诱导的中脑原代细胞损伤的保护作用[D]: [硕士学位论文]. 郑州: 郑州大学, 2018.
[37]  Singh, U., Barik, A., Singh, B.G. and Priyadarsini, K.I. (2011) Reactions of Reactive Oxygen Species (ROS) with Curcumin Analogues: Structure-Activity Relationship. Free Radical Research, 45, 317-325.
https://doi.org/10.3109/10715762.2010.532493
[38]  倪琦, 林化. 姜黄素预处理对缺血-再灌注所致急性肾损伤大鼠肾组织血管内皮修复和内皮祖细胞归巢的影响[J]. 广西医学, 2021, 43(22): 2699-2703.
[39]  许传俊, 明艳林, 陈良华, 黄雯. 姜黄素在2型糖尿病及其慢性并发症中作用及机制的研究进展[J]. 安徽农业科学, 2021, 49(6): 30-34+38.
[40]  李建波, 张静, 罗永锋, 李小珩. 姜黄素对高浓度葡萄糖诱导的RF/6A细胞血管生成的抑制作用[J]. 中国中医眼科杂志, 2020, 30(6): 396-401.
[41]  Moghadamtousi, S.Z., Kadir, H.A., Hassandarvish, P., Ta-jik, H., Abubakar, S. and Zandi, K. (2014) A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin. BioMed Research International, 2014, Article ID: 186864.
https://doi.org/10.1155/2014/186864
[42]  Vajragupta, O., Boonchoong, P., Morris, G.M. and Olson, A.J. (2005) Active Site Binding Modes of Curcumin in HIV-1 Protease and Integrase. Bioorganic & Medicinal Chemistry Letters, 15, 3364-3368.
https://doi.org/10.1016/j.bmcl.2005.05.032
[43]  李丽, 陈鹤, 匡艳青, 周旖璇, 张纯刚. 姜黄素制剂研究进展[J]. 广州化工, 2021, 49(16): 1-3+23.
[44]  刘佳, 黄宇虹, 王保和, 刘昌孝. 姜黄素类化合物体内代谢途径及其代谢产物的研究进展[J]. 现代药物与临床, 2015, 30(12): 1553-1557.

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