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亚临床甲状腺功能减退症与心血管疾病血栓形成相关性研究进展
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Abstract:
甲状腺功能与机体能量代谢和生长发育密切相关，并与多种心血管活动紧密相关。近年来的研究表明，甲状腺功能障碍患者的外周血抗凝指标存在明显异常，而凝血性能的改变与心血管疾病的发生发展有一定的相关性。亚临床甲状腺功能减退症(subclinical hypothyroidism, SCH)是介于临床甲减和正常人之间的过渡状态，目前对于不同程度SCH患者与心血管疾病血栓形成的相关性研究存在争议。本文就亚临床甲减与血栓形成的机制、冠心病危险因素的相关性及预后等最新进展做一综述。
Thyroid function is closely related to the body’s energy metabolism, growth and development, and is closely related to a variety of cardiovascular activities. Studies in recent years have shown that there are obvious abnormalities in peripheral blood anticoagulation indexes in patients with thy-roid dysfunction, and the changes in coagulation properties are related to the occurrence and de-velopment of cardiovascular diseases. Subclinical hypothyroidism (SCH) is a transitional state be-tween clinical hypothyroidism and normal individuals. At present, there is controversy about the relationship between patients with different degrees of SCH and thrombosis of cardiovascular dis-ease. This article reviews the latest progress in the mechanism of subclinical hypothyroidism and thrombosis, and the correlation between coronary heart disease risk factors and prognosis.
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