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Medical Diagnosis 2022
OPG/RANKL/RANK信号通路在早发冠心病中的研究进展
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Abstract:
早发冠状动脉粥样硬化性心脏病(premature coronary heart disease, PCHD)是冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease, CHD)特有的种类，具有起病急、发病隐匿、年轻化、高病发率、高致死率等特征，会带来严重的不良后果。过去关于OPG/RANKL/RANK信号轴在骨骼系统发面研究的较多，近年来在心血管疾病(cardiovascular disease, CVD)的研究中也引起了广泛关注，因此探索对PCHD有意义的信号轴对于今后PCHD的发生、演变、治疗、预后等十分有意义。
Premature coronary heart disease (PCHD) is a unique type of coronary atherosclerotic heart disease (CHD). With acute onset, hidden onset, young, high incidence, high mortality and other characteristics, it will bring serious adverse consequences. In the past, there have been many studies on OPG/RANKL/RANK signal axis in skeletal system. In recent years, it has also attracted wide attention in the studies of cardiovascular disease (CVD). Therefore, the exploration of significant signal axis for PCHD is of great significance for the occurrence, evolution, treatment and prognosis of PCHD in the future.
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