全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

儿童喘息性支气管肺炎发病机制及治疗研究进展
Advances in Pathogenesis and Treatment of Asthmatic Bronchial Pneumonia in Children

DOI: 10.12677/ACM.2022.1281156, PP. 8027-8034

Keywords: 喘息性支气管肺炎,发病机制,治疗,综述
Asthmatic Bronchial Pneumonia
, Pathogenesis, Treatment, Review of Literature

Full-Text   Cite this paper   Add to My Lib

Abstract:

喘息性支气管肺炎属于一种临床综合征,致病因素比较复杂,然而该病的发病机制并不清楚,临床上缺乏有效的防治措施,因此为患者寻找更好的治疗方法仍是临床迫切需要解决的问题。本文主要对儿童喘息性肺炎的发病机制、相关治疗等进行汇总。
Asthmatic bronchial pneumonia is a clinical syndrome. The pathogenic factors are complex. How-ever, pathogenesis of this disease is barely known. At present, there is a lack of effective prevention and treatment measures clinically. Therefore, there is an urgent need to find an effective treatment for patients. The primary objective of this article is to highlight the current understanding and summarize the most recent advances in the pathogenesis and management of Asthmatic bronchial pneumonia in children.

References

[1]  陈毅克. 阿奇霉素联合多索茶碱治疗喘息性支气管肺炎患儿的临床效果[J]. 中外医学研究, 2019, 17(10): 30-32.
[2]  Qiu, Y.Y., Zhang, Y.W., Qian, X.F., et al. (2017) miR-371, miR-138, miR-544, miR-145, and miR-214 Could Modulate Th1/Th2 Balance in Asthma through the Combinatorial Regulation of Runx3. The American Journal of Translational Research, 9, 3184-3199.
[3]  Corrard, F., de La Rocque, F., Martin, E., et al. (2013) Food Intake during the Previous 24 h as a Percentage of Usual Intake: A Marker of Hypoxia in Infants with Bronchiolitis: An Observational, Prospective, Multicenter Study. BMC Pediatrics, 13, Article No. 6.
https://doi.org/10.1186/1471-2431-13-6
[4]  Krane, C.M., Fortner, C.N., Hand, A.R., et al. (2001) Aquaporin 5-Deficient Mouse Lungs Are Hyperresponsive to Cholinergic Stim-ulation. Proceedings of the National Academy of Sciences of the United States of America, 98, 14114-14119.
https://doi.org/10.1073/pnas.231273398
[5]  Fernandez-Petty, C.M., Hughes, G.W., Bowers, H.L., et al. (2019) A Glycopolymer Improves Vascoelasticity and Mucociliary Transport of Abnormal Cystic Fibrosis Mucus. JCI Insight, 4, e125954.
https://doi.org/10.1172/jci.insight.125954
[6]  Caggiano, S., Ullmann, N., De Vitis, E., et al. (2017) Factors That Negatively Affect the Prognosis of Pediatric Community-Acquired Pneumonia in District Hospital in Tanzania. Interna-tional Journal of Molecular Sciences, 18, Article No. 623.
https://doi.org/10.3390/ijms18030623
[7]  何敏. 氨溴特罗口服液辅助治疗小儿喘息性疾病的疗效[J]. 深圳中西医结合杂志, 2020, 30(16): 101-102.
[8]  栾馥, 满丽娜, 王坤, 等. 布地奈德、沙丁胺醇、异丙托溴铵联合雾化吸入治疗小儿喘息性肺炎的疗效分析[J]. 中国现代药物应用, 2020, 14(16): 150-152.
[9]  汤华平, 马泽南, 邹公民, 等. 布地奈德联合硫酸镁用于治疗小儿喘息性支气管肺炎的疗效研究[J]. 系统医学, 2021, 6(23): 121-124.
[10]  罗乔芬. 1例喘息性支气管肺炎患儿的个案护理[J]. 世界最新医学信息文摘, 2019, 19(51): 335-337.
[11]  张晓佳, 刘丽秀, 张艳春. 布地奈德联合氢化可的松治疗喘息性支气管肺炎患儿的疗效[J]. 医疗装备, 2020, 33(3): 77-78.
[12]  阳梅, 梁瑞添, 陈嵘峰. 酮替芬+布地奈德治疗小儿喘息性支气管肺炎的疗效分析[J]. 北方药学, 2020, 17(4): 147-148.
[13]  雷辉, 谭娴玲, 刘婷. 学龄前儿童支气管肺炎引起的反复喘息危险因素分析[J]. 中国处方药, 2020, 18(11): 152-153.
[14]  Duan, Y., Zhou, H. and Chen, J. (2021) The Effects of the Atomization Inhalation of Budesonide, Salbutamol, and Ipratropium Bromide on the T-Lymphocyte Subset and Inflammatory Cytokine Levels in Children with Asthmatic Pneumonia. The American Journal of Translational Research, 13, 10517-10526.
[15]  栗守芳. 布地奈德、异丙托溴铵、沙丁胺醇联合雾化吸入治疗小儿喘息性肺炎的效果研究[J]. 临床医药文献电子杂志, 2018, 5(47): 125-126.
[16]  李雪峰. 布地奈德联合孟鲁司特钠治疗小儿喘息性支气管肺炎的临床效果[J]. 临床医学研究与实践, 2020, 5(23): 92-94.
[17]  Barr, R., Green, C.A., Sande, C.J., et al. (2019) Respiratory Syncytial Virus: Diagnosis, Prevention and Management. Therapeutic Advances in Infectious Disease, 6, Article ID: 230907450.
https://doi.org/10.1177/2049936119865798
[18]  Jartti, T., Smits, H.H., Bonnelykke, K., et al. (2019) Bronchiolitis Needs a Revisit: Distinguishing between Virus Entities and Their Treatments. Allergy, 74, 40-52.
https://doi.org/10.1111/all.13624
[19]  相春雷. 6岁以下儿童急性喘息性疾病病原学与临床特点研究[J]. 基层医学论坛, 2020, 24(19): 2716-2717.
[20]  朱从敬, 黄斯铭, 蔡广创. 布地奈德、异丙托溴胺与沙丁胺醇联合氧气雾化治疗小儿喘息性肺炎的效果观察[J]. 北方药学, 2019, 16(11): 113-114.
[21]  李海涛. 布地奈德联合特布他林雾化吸入治疗小儿喘息性肺炎的临床观察[J]. 临床医学, 2019, 39(10): 116-118.
[22]  Kavaliunaite, E. and Aurora, P. (2019) Diagnosing and Managing Bronchiolitis Obliterans in Children. Expert Review of Respiratory Medicine, 13, 481-488.
https://doi.org/10.1080/17476348.2019.1586537
[23]  苏锋. 布地奈德联合孟鲁司特纳对喘息性肺炎患儿免疫球蛋白及降钙素原的影响[J]. 世界临床药物, 2019, 40(8): 572-575.
[24]  汪龙辉, 丁国标, 匡云. 小儿咳喘灵颗粒联合孟鲁司特钠对小儿喘息性肺炎的疗效及血清IgE、IL-6、C-反应蛋白和嗜酸性粒细胞的影响[J]. 中药材, 2018, 41(4): 996-998.
[25]  杨春艳. 药物和雾化吸入联合治疗小儿喘息性肺炎的临床效果及护理措施分析[J]. 中国实用医药, 2019, 14(11): 97-99.
[26]  陈国光, 张志博. 肺炎支原体肺炎患儿血清急性时相反应蛋白及血小板活化指标的变化观察[J]. 中国医学创新, 2022, 19(5): 57-60.
[27]  张渊源, 李成尧, 高文娟, 等. 潮气呼吸肺功能在喘息性疾病患儿中的应用研究[J]. 中国妇幼健康研究, 2021, 32(10): 1508-1512.
[28]  余小河, 何苗, 郑湘榕, 等. 喘息婴幼儿外周血气道炎症相关介质水平的研究[J]. 中国当代儿科杂志, 2019, 21(9): 861-867.
[29]  周本伟. 布地奈德规律吸入对毛细支气管炎反复喘息患儿喘息复发率及炎性因子的影响[J]. 微量元素与健康研究, 2020, 37(1): 93-94.
[30]  何巧利, 孙婕. 特步他林联合布地奈德雾化吸入治疗小儿喘息性肺炎的临床效果[J]. 临床医学研究与实践, 2021, 6(13): 87-89.
[31]  Xu, B., Gao, H., Li, D., et al. (2020) Nebulized Dexmedetomidine Im-proves Pulmonary Shunt and Lung Mechanics during One-Lung Ventilation: A Randomized Clinical Controlled Trial. PeerJ, 8, e9247.
https://doi.org/10.7717/peerj.9247
[32]  Lee, Y.J. and Kim, C.K. (2020) Montelukast Use over the Past 20 Years: Monitoring of Its Effects and Safety Issues. Clinical and Experimental Pediatrics, 63, 376-381.
https://doi.org/10.3345/cep.2019.00325
[33]  郭立平, 刘卓, 白平生. 孟鲁司特纳口服辅助治疗儿童哮喘疗效分析[J]. 内蒙古中医药, 2010, 29(21): 11-12.
[34]  欧景怡. 儿科住院患儿盐酸氨溴索注射液使用分析[J]. 实用医技杂志, 2021, 28(4): 530-531.
[35]  肖静静. 呼吸系统疾病患儿经盐酸氨溴索注射液治疗后的临床价值分析[J]. 中外医疗, 2020, 39(25): 97-99.
[36]  肖文义. 沐舒坦治疗儿科呼吸系统疾病的疗效观察[J]. 中国实用医药, 2021, 16(9): 125-127.
[37]  Kang, Q., Zhang, X., Liu, S., et al. (2018) Correlation between the Vitamin D Levels and Asthma Attacks in Children: Evaluation of the Effects of Combination Therapy of Atomization Inhalation of Budesonide, Albut-erol and Vitamin D Supplementation on Asthmatic Patients. Experimental and Therapeutic Medicine, 15, 727-732.
https://doi.org/10.3892/etm.2017.5436
[38]  巫艳艳, 谢玲, 黄骋, 等. 布地奈德联合复方异丙托溴铵气雾剂雾化吸入治疗喘息性支气管肺炎的疗效对比研究[J]. 吉林医学, 2020, 41(10): 2434-2437.
[39]  徐国兴. 特布他林联合糖皮质激素治疗喘息性支气管肺炎患儿的临床疗效[J]. 医疗装备, 2021, 34(15): 118-119.
[40]  周菁. 布地奈德联合特布他林治疗小儿先天性心脏病合并喘息性肺炎的效果观察[J]. 心血管病防治知识(学术版), 2020, 10(12): 3-5.
[41]  王克成. 布地奈德联合异丙托溴铵及沙丁胺醇治疗小儿喘息性肺炎疗效分析[J]. 中国社区医师, 2019, 35(8): 81-84.
[42]  吕晓丽. 异丙托溴铵对喘息性肺炎患儿血清IgE、CRP水平的影响与安全性分析[J]. 现代医学与健康研究电子杂志, 2021, 5(7): 43-45.
[43]  卜范玉. 氨茶碱与多索茶碱在支气管哮喘治疗中的疗效比较[J]. 中国医药指南, 2021, 19(25): 40-41.
[44]  王易难. 氨茶碱和多索茶碱治疗支气管哮喘的临床效果分析[J]. 中国实用医药, 2021, 16(25): 132-134.
[45]  李小鹏, 李伟, 刘世明. 多索茶碱与氨茶碱在支气管哮喘患者中的疗效对比观察及对肺功能的影响研究[J]. 贵州医药, 2021, 45(10): 1559-1560.
[46]  钱许义. 小儿喘息性疾病治疗中硫酸镁与氨茶碱的效果分析[J]. 当代医学, 2021, 27(30): 11-13.
[47]  McGeachie, M.J., Sordillo, J.E., Dahlin, A., et al. (2020) Expression of SMARCD1 Interacts with Age in Association with Asthma Control on Inhaled Corticosteroid Therapy. Respiratory Research, 21, Article No. 31.
https://doi.org/10.1186/s12931-020-1295-4
[48]  You, P., Chen, N., Su, L., et al. (2018) Local Level of TGF-beta1 Determines the Effectiveness of Dexamethasone through Regulating the Balance of Treg/Th17 Cells in TNBS-Induced Mouse Colitis. Experimental and Therapeutic Medicine, 15, 3639-3649.
https://doi.org/10.3892/etm.2018.5852
[49]  金博. 匹多莫德联合丙酸氟替卡松对哮喘患儿免疫功能及儿童哮喘控制测试评分的影响[J]. 实用医技杂志, 2021, 28(7): 932-933.
[50]  Zhou, H., Chen, S., Zhou, Q., et al. (2016) Cross-Species Antiviral Activity of Goose Inter-ferons against Duck Plague Virus Is Related to Its Positive Self-Feedback Regulation and Subsequent Interferon Stimu-lated Genes Induction. Viruses, 8, Article No. 195.
https://doi.org/10.3390/v8070195
[51]  Jiang, R., Han, B., Song, M., et al. (2020) Efficacy and Safety of Aerosol Inhalation of Recombinant Human Interferon alpha1b (IFNalpha1b) In-jection for Noninfluenza Viral Pneumonia, a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Inflammation (London), 17, Article No. 19.
https://doi.org/10.1186/s12950-020-00249-1
[52]  李瑞. 60例干扰素α-1b雾化吸入辅助治疗小儿喘息性肺炎的临床分析[J]. 医学理论与实践, 2017, 30(24): 3646-3647.
[53]  韩蕾, 池燕, 韩芙丽, 等. 重组人干扰素α1b对呼吸道合胞病毒感染小鼠免疫炎症反应作用机制研究[J]. 中国临床药理学杂志, 2022, 38(14): 1639-1643.
[54]  徐瓅, 夏锦华. 注射用重组人干扰素α1b联合孟鲁司特钠对支气管肺炎患儿症状改善及复发率的影响[J]. 中国处方药, 2021, 19(11): 117-118.
[55]  Chen, L., Shi, M., Deng, Q., et al. (2020) A Multi-Center Randomized Prospective Study on the Treatment of Infant Bronchiolitis with Interferon alpha1b Nebulization. PLOS ONE, 15, e228391.
https://doi.org/10.1371/journal.pone.0228391
[56]  申昆玲, 尚云晓, 张国成, 等. α干扰素在儿科临床合理应用专家共识[J]. 中华实用儿科临床杂志, 2018, 33(17): 1301-1308.
[57]  Schroeder, A.R. and Mansbach, J.M. (2014) Recent Evidence on the Management of Bronchiolitis. Current Opinion in Pediatrics, 26, 328-333.
https://doi.org/10.1097/MOP.0000000000000090
[58]  Yoshihara, S., Kusuda, S., Mochizuki, H., et al. (2013) Ef-fect of Palivizumab Prophylaxis on Subsequent Recurrent Wheezing in Preterm Infants. Pediatrics, 132, 811-818.
https://doi.org/10.1542/peds.2013-0982
[59]  张文静. 穴位贴敷联合麻杏石甘汤治疗小儿喘息性支气管肺炎的临床疗效分析[J]. 中医外治杂志, 2021, 30(3): 62-64.
[60]  Lin, C.Y., Yeh, T.L., Liu, S.J., et al. (2018) Effects of Macrolide Treatment during the Hospitalization of Children with Childhood Wheezing Disease: A Systematic Review and Me-ta-Analysis. Journal of Clinical Medicine, 7, Article No. 432.
https://doi.org/10.3390/jcm7110432

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133