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p53基因与肿瘤的研究进展
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Abstract:
目前临床研究表明，p53基因的主要作用是识别细胞损伤从而诱导细胞凋亡，该基因突变可能导致许多肿瘤发生发展。尤其在肺癌中，p53基因突变是NSCLC存活率降低的独立预后因素，并且基因突变可导致EGFR-TKI耐药，但是在免疫治疗方面等影响尚未明确。p53基因突变往往伴随着p53蛋白构象的改变。已发现AZD1775、APR-246等小分子可能有恢复p53野生型构象并重建其正常功能的作用。在这篇综述中，我们总结了p53基因目前的一些研究观点及研究进展，希望对临床肿瘤的治疗有所帮助。
Current clinical studies have shown that the main role of p53 gene is to recognize cell damage and induce apoptosis, and the mutation of this gene may lead to the occurrence and development of many tumors. Especially in lung cancer, p53 gene mutation is an independent prognostic factor of reduced survival rate of NSCLC, and gene mutation can lead to EGFR-TKI resistance, but the effect on immunotherapy is not clear. P53 gene mutations are often accompanied by conformation changes of p53 protein. It has been found that AZD1775, APR-246 and other small molecules may restore the wild-type conformation of p53 and restore its normal function. In this review, we summarize some current research views and progress of p53 gene, hoping to be helpful for the treatment of clinical tumors.
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