|
|
粪便Hp抗原检测对UBT假阴性患者的诊断意义
|
Abstract:
在诊断幽门螺杆菌(Hp)感染的非侵入性检测中，尿素呼气试验(UBT)具有很高的敏感性与特异性，是最常用的检测方法，但在临床中易受到多种因素干扰从而影响检测效果。近年来，粪便抗原检测(HpSA)以其较高的敏感性与特异性以及较低的成本成为诊断Hp感染的常用检测方法，本文将评价尿素呼气试验易出现假阴性的患者中实行粪便抗原检测的可靠性以及其诊断意义。
Among the non-invasive tests for the diagnosis of Helicobacter pylori (Hp) infection, the urea breath test (UBT) has high sensitivity and specificity and is the most commonly used test, but it is suscep-tible to interference by various factors in the clinical setting, thus affecting the effectiveness of the test. In recent years, Hp stool antigen test (HpSA) has become a common test for the diagnosis of Hp infection due to its high sensitivity and specificity and low cost. In this paper, we will evaluate the reliability and diagnostic value of stool antigen test in patients with false negative urea breath test.
| [1] | Zamani, M., Ebrahimtabar, F., Zamani, V., et al. (2018) Systematic Review with Meta-Analysis: The Worldwide Preva-lence of Helicobacter pylori Infection. Alimentary Pharmacology & Therapeutics, 47, 868-876.
https://doi.org/10.1111/apt.14561 |
| [2] | Sabbagh, P., Mohammadnia-Afrouzi, M., Javanian, M., et al. (2019) Di-agnostic Methods for Helicobacter pylori Infection: Ideals, Options, and Limitations. European Journal of Clinical Mi-crobiology & Infectious Diseases, 38, 55-66.
https://doi.org/10.1007/s10096-018-3414-4 |
| [3] | Kamboj, A.K., Cotter, T.G. and Oxentenko, A.S. (2017) Helico-bacter pylori: The Past, Present, and Future in Management. Mayo Clinic Proceedings, 92, 599-604. https://doi.org/10.1016/j.mayocp.2016.11.017 |
| [4] | Best, L.M., Takwoingi, Y., Siddique, S., et al. (2018) Non-Invasive Diagnostic Tests for Helicobacter pylori Infection. Cochrane Database of Systematic Reviews, No. 3, Ar-ticle No. CD012080.
https://doi.org/10.1002/14651858.CD012080.pub2 |
| [5] | Chen, M.J., Fang, Y.J., Wu, M.S., et al. (2020) Applica-tion of Helicobacter pylori Stool Antigen Test to Survey the Updated Prevalence of Helicobacter pylori Infection in Tai-wan. Journal of Gastroenterology and Hepatology, 35, 233-240. https://doi.org/10.1111/jgh.14828 |
| [6] | 张磊, 许建明. 幽门螺杆菌感染处理共识解读及实施意见[J]. 安徽医学, 2016, 37(11): 1319-1323. |
| [7] | Guevara, B. and Cogdill, A.G. (2020) Helicobacter pylori: A Review of Current Diagnostic and Management Strategies. Digestive Dis-eases and Sciences, 65, 1917-1931. https://doi.org/10.1007/s10620-020-06193-7 |
| [8] | 安徽省消化内科质量控制中心. 14C尿素呼气试验质量控制方案(2018年版) [J]. 安徽医学, 2019, 40(1): 前插3-前插6. |
| [9] | Mcnicholl, A.G., Garre, A., Llorca, L., et al. (2020) Prospective, Study Comparing the Accuracy of Two Different Stool Antigen Tests (Premier Platinum Hpsa and Novel Immunocard Stat! Rapid Test) for the Diagnosis of Helicobacter pylori Infection. Gastroenterología y Hepatología, 43, 117-125. https://doi.org/10.1016/j.gastrohep.2019.09.009 |
| [10] | Malfertheiner, P., Megraud, F., O’Morain, C., et al. (2017) Management of Helicobacter pylori Infection—The Maastricht Ⅴ/Florence Consensus Report. Gut, 66, 6-30. https://doi.org/10.1136/gutjnl-2016-312288 |
| [11] | 刘文忠, 谢勇, 陆红, 成虹, 曾志荣, 周丽雅, 等. 第五次全国幽门螺杆菌感染处理共识报告[J]. 胃肠病学, 2017, 22(6): 346-360. |
| [12] | Tian, X.Y., Zhu, H., Zhao, J., et al. (2012) Diagnostic Performance of Urea Breath Test, Rapid Urea Test, and Histology for Helicobacter pylori Infection in Patients with Partial Gastrectomy: A Meta-Analysis. Journal of Clinical Gastroenterol-ogy, 46, 285-292. https://doi.org/10.1097/MCG.0b013e318249c4cd |
| [13] | Liu, W.Z., Xie, Y., Lu, H., et al. (2018) Fifth Chinese National Consensus Report on the Management of Helicobacter pylori infection. Helicobacter, 23, Article ID: e12475. https://doi.org/10.1111/hel.12475 |
| [14] | 冉丹, 张振玉. 休斯敦共识会议: 关于美国幽门螺杆菌感染的检测[J]. 中国微生态学杂志, 2020, 32(3): 340-344. |
| [15] | Georgopoulos, S.D., Michopoulos, S., Rokkas, T., et al. (2020) Hellenic Consensus on Helicobacter pylori Infection. Annals of Gastroenterology, 33, 1-21. https://doi.org/10.20524/aog.2020.0446 |
| [16] | Bravo, L.E., Realpe, J.L., Campo, C., et al. (1999) Effects of Acid Suppression and Bismuth Medications on the Performance of Diagnostic Tests for Helicobacter pylori Infection. Ameri-can Journal of Gastroenterology, 94, 2380-2383.
https://doi.org/10.1111/j.1572-0241.1999.01361.x |
| [17] | Lahner, E., Carabotti, M. and Annibale, B. (2018) Treat-ment of Helicobacter pylori Infection in Atrophic Gastritis. World Journal of Gastroenterology, 24, 2373-2380. https://doi.org/10.3748/wjg.v24.i22.2373 |
| [18] | Jeong, M., Park, J.M., Han, Y.M., et al. (2016) Dietary Interven-tion of Artemisia and Green Tea Extracts to Rejuvenate Helicobacter pylori-Associated Chronic atrophic Gastritis and to Prevent Tumorigenesis. Helicobacter, 21, 40-59.
https://doi.org/10.1111/hel.12229 |
| [19] | Alzoubi, H., Al-Mnayyis, A., Al Rfoa, I., et al. (2020) The Use of 13C-Urea Breath Test for Non-Invasive Diagnosis of Helicobacter pylori Infection in Comparison to Endoscopy and Stool Antigen Test. Diagnostics, 10, Article No. 448.
https://doi.org/10.3390/diagnostics10070448 |
| [20] | Kwon, Y.H., Kim, N., Yoon, H., et al. (2019) Effect of Citric Acid on Accuracy of 13C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Preva-lence of Atrophic Gastritis. Gut Liver, 13, 506-514.
https://doi.org/10.5009/gnl18398 |
| [21] | Furuta, T., Baba, S., Yamade, M., et al. (2018) High Incidence of Autoim-mune Gastritis in Patients Misdiagnosed with Two or More Failures of H. pylori Eradication. Alimentary Pharmacology & Therapeutics, 48, 370-377.
https://doi.org/10.1111/apt.14849 |
| [22] | V？rhendi, N., Soós, A., Anne Engh, M., et al. (2020) Accuracy of the Hel-icobacter pylori Diagnostic Tests in Patients with Peptic Ulcer Bleeding: A Systematic Review and Network Me-ta-Analysis. Therapeutic Advances in Gastroenterology, 13, Article ID: 1756284820965324. https://doi.org/10.1177/1756284820965324 |
| [23] | 王醒, 高广周, 石峥, 郝英霞. 粪便幽门螺杆菌检测在上消化道溃疡出血患者中的价值[J]. 世界最新医学信息文摘, 2019, 19(25): 165-166. |
| [24] | Yan, J., Yamaguchi, T., Odaka, T., et al. (2010) Stool Antigen Test Is a Reliable Method to Detect Helicobacter pylori in the Gastric Remnant af-ter Distal Gastrectomy for Gastric Cancer. Journal of Clinical Gastroenterology, 44, 73-74.
https://doi.org/10.1097/MCG.0b013e3181aae65e |
| [25] | Sheu, B.S., Yang, H.B., Wang, Y.L., et al. (2002) Stool Antigen Assay to Screen H. pylori Infection and to Assess the Success of 3-Day and 7-Day Eradication Therapy in the Patients with Partial Gastrectomy. Helicobacter, 7, 199-204.
https://doi.org/10.1046/j.1523-5378.2002.00081.x |
| [26] | Kodama, M., Murakami, K., Okimoto, T., et al. (2012) In-fluence of Proton Pump Inhibitor Treatment on Helicobacter pylori stool Antigen Test. World Journal of Gastroenterol-ogy, 18, 44-448. https://doi.org/10.3748/wjg.v18.i1.44 |
| [27] | Asfeldt, A.M., L？chen, M.L., Straume, B., et al. (2004) Accuracy of a Monoclonal Antibody-Based Stool Antigen Test in the Diagnosis of Helicobacter pylori Infection. Scan-dinavian Journal of Gastroenterology, 39, 1073-1077.
https://doi.org/10.1080/00365520410007944 |
| [28] | 于涛, 文卓夫, 尹颂超. 质子泵抑制剂对幽门螺杆菌粪便抗原检测的影响[J]. 中华消化杂志, 2007, 27(6): 421-422. |
| [29] | Shimoyama, T., Kato, C., Kodama, M., et al. (2009) Applicability of a Monoclonal Antibody-Based Stool Antigen Test to Evaluate the Results of Helicobacter pylori Eradi-cation Therapy. Japanese Journal of Infectious Diseases, 62, 225-227. |
| [30] | Shimoyama, T., Oyama, T., Matsuzaka, M., et al. (2009) Comparison of a Stool Antigen Test and Serology for the Diagnosis of Helicobacter pylori Infection in Mass Survey. Helicobacter, 14, 87-90.
https://doi.org/10.1111/j.1523-5378.2009.00672.x |
| [31] | Gri？ó, P., Pascual, S., Such, J., et al. (2003) Comparison of Stool Immunoassay with Standard Methods for Detection of Helicobacter pylori Infection in Patients with Up-per-Gastrointestinal Bleeding of Peptic Origin. European Journal of Gastroenterology & Hepatology, 15, 525-529. https://doi.org/10.1097/01.meg.0000059114.41030.a9 |
| [32] | Gisbert, J.P. and Abraira, V. (2006) Accuracy of Hel-icobacter pylori Diagnostic Tests in Patients with Bleeding Peptic Ulcer: A Systematic Review and Meta-Analysis. American Journal of Gastroenterology, 101, 848-863.
https://doi.org/10.1111/j.1572-0241.2006.00528.x |
| [33] | Moubri, M., Burucoa, C., Kalach, N., et al. (2019) Per-formances of the Ideia Hpstar Stool Antigen Test in Detection of Helicobacter pylori Infection Before and After Eradica-tion Treatment in Algerian Children. Journal of Tropical Pediatric, 65, 210-216. https://doi.org/10.1093/tropej/fmy035 |
| [34] | El-Shabrawi, M., El-Aziz, N.A., El-Adly, T.Z., et al. (2018) Stool An-tigen Detection versus 13C-Urea Breath Test for Non-Invasive Diagnosis of Pediatric Helicobacter pylori Infection in a Limited Resource Setting. Archives of Medical Science, 14, 69-73. https://doi.org/10.5114/aoms.2016.61031 |
