七叶皂苷钠应用于胫腓骨干骨折病人围术期肿胀的临床研究
The Effect of Sodium Aescinate Tablets for Swelling in Perioperative Period of Tibiofibular Fracture Patients

目的：观察七叶皂苷钠应用于胫腓骨干骨折病人围术期消肿的临床效果。方法：选取2020年6月~2021年11月于某三级甲等医院创伤骨科行胫腓骨干骨折病人共50例，根据是否应用七叶皂苷钠分为对照和实验组，每组各25例患者。对照组采用物理消肿方法，实验组采用口服七叶皂苷钠联合物理量消肿的方法进行消肿。观察两组患者比较伤后第5天与第1天差值评估术前消肿效果，通过比较术后第5天与术后第1天差值比较术后消肿效果，同时通过评分差值对疼痛改善情况进行评估。结果：试验组患者较对照组有明显的术前消肿效果(P < 0.05)，两组患者在术前及术后的疼痛缓解程度及术后消肿程度上无明显差异(P > 0.05)。结论：采用七叶皂苷钠联合物理消肿能有效改善围术期胫腓骨干骨折患者肢体肿胀情况。
Objective: The clinical effect of sodium aescinate tablets for swelling in perioperative period of tibi-ofibular fractures was observed. Methods: From June 2020 to November 2021, 50 cases with tibio-fibular shaft fractures and got admission in the department of orthopaedics were collected. They were divided into the control group and the test group based on the application of sodium aescinate tablets. Patients in the control group were dealt with physical methods for swelling and in the test group, they suffered with both sodium aescinate tablets and physical methods. The evaluation for preoperative and postoperative effect of swelling were based on the difference between 5th and 1st day after injury, and difference between 5th and 1st day after operation. And the pain improved was evaluated via differences of those values. Results: Patients in the test group had an obvious effect on swelling remove than in the control group (P < 0.05). While the pain relieving and effect on postop-erative swelling had no differences (P > 0.05). Conclusion: The combination of sodium aescinate tablets and physical methods had great effect on the swelling in perioperative period of tibiofibular fractures.