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甲状腺功能与2型糖尿病大血管并发症关系的研究进展
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Abstract:
2型糖尿病(T2DM)和甲状腺疾病是临床上最常见的两大内分泌代谢性疾病。T2DM患者的长期糖代谢失调会影响到身体的各个重要器官，而心脑血管病如冠心病、脑梗死等，会对病人的生命和生活质量造成重要影响。越来越多的研究表明甲状腺功能异常可能与糖尿病的发病过程以及T2DM并发症有关，尤其是T2DM合并甲状腺功能减退的患者，会引起多系统损害从而发生功能减退或衰竭，促进大血管并发症的发生。因此，本文就甲状腺功能异常与T2DM大血管并发症之间的研究进展进行综述。
Type 2 diabetes mellitus (T2DM) and thyroid disease are the two most common endocrine and metabolic diseases. Long-term disorder of glucose metabolism in patients with T2DM will affect the important organs of the whole body, while cardiovascular and cerebrovascular diseases, such as coronary heart disease and cerebral infarction, will have an important impact on life span and sur-vival quality of patients. More and more studies have shown that thyroid dysfunction may be in-volved in the pathogenesis of diabetes and complications of T2DM, especially in patients with T2DM complicated with hypothyroidism, which may cause multi-system damage, resulting in hypofunc-tion or failure, promoting the occurrence of macrovascular complications. Therefore, This research progress on the relationship between thyroid dysfunction and macrovascular complications of T2DM have been reviewed in present paper.
| [1] | 方珂, 陆付耳. 糖尿病与甲状腺疾病密切相关的病理生理基础[J]. 医学综述, 2016, 22(5): 950-954. |
| [2] | Duntas, L.H., Orgiazzi, J. and Brabant, G. (2011) The Interface between Thyroid and Diabetes Mellitus. Clinical Endocrinology (Oxford), 75, 1-9. https://doi.org/10.1111/j.1365-2265.2011.04029.x |
| [3] | 郭新红, 张青春, 孔艳华, 等. 2型糖尿病甲状腺功能正常病人甲状腺激素与代谢指标的相关性分析[J]. 蚌埠医学院学报, 2021, 46(8): 1041-1044. |
| [4] | 洪燕青, 邸阜生. TSH、血脂水平及肾功能、甲状腺功能与2型糖尿病患者肾损伤的相关性[J]. 贵州医科大学学报, 2021, 46(3): 362-366. |
| [5] | Sun, H., Saeedi, P., Karuranga, S., et al. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Re-search and Clinical Practice, 183, Article ID: 109119. https://doi.org/10.1016/j.diabres.2021.109119 |
| [6] | 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版) [J]. 国际内分泌代谢杂志, 2021, 41(5): 482-548. |
| [7] | Wang, L., Gao, P., Zhang, M., et al. (2017) Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013. JAMA, 317, 2515-2523. https://doi.org/10.1001/jama.2017.7596 |
| [8] | Marushchak, M., Vivsiana, I., Musiienko, V., et al. (2022) Subclinical Hypothyroidism as a Contributor to Macrovascular Complications in Patients with Type 2 Diabetes Mellitus. Acta Clinica Croatica, 60, 483-495.
https://doi.org/10.20471/acc.2021.60.03.20 |
| [9] | 王玫, 任安. 亚临床甲状腺功能减退与糖尿病血管并发症[J]. 国际病理科学与临床杂志, 2012, 32(1): 35-39. |
| [10] | Mohammed, H.S. and Abdelmageed, R.M. (2021) The Relation-ship between Type 2 Diabetes Mellitus and Related Thyroid Diseases. Cureus, 13, e20697. |
| [11] | Kalra, S., Aggarwal, S. and Khandelwal, D. (2019) Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management. Diabetes Therapy, 10, 2035-2044.
https://doi.org/10.1007/s13300-019-00700-4 |
| [12] | Cettour-Rose, P., Theander-Carrillo, C., Asensio, C., et al. (2005) Hypothyroidism in Rats Decreases Peripheral Glucose Utilisation, a Defect Partially Corrected by Central Leptin Infusion. Diabetologia, 48, 624-633.
https://doi.org/10.1007/s00125-005-1696-4 |
| [13] | Rochon, C., Tauveron, I., Dejax, C., et al. (2003) Response of Glucose Disposal to Hyperinsulinaemia in Human Hypothyroidism and Hyperthyroidism. Clinical Science (London), 104, 7-15. https://doi.org/10.1042/CS20020154 |
| [14] | Meng, Z., Liu, M., Zhang, Q., et al. (2015) Gender and Age Impacts on the Association between Thyroid Function and Metabolic Syndrome in Chinese. Medicine (Baltimore), 94, e2193. https://doi.org/10.1097/MD.0000000000002193 |
| [15] | Cooper, D.S. and Biondi, B. (2012) Subclinical Thy-roid Disease. The Lancet, 379, 1142-1154.
https://doi.org/10.1016/S0140-6736(11)60276-6 |
| [16] | Al-Hamodi, Z., Al-Habori, M., Al-Meeri, A., et al. (2014) Association of Adipokines, Leptin/Adiponectin Ratio and C-Reactive Protein with Obesity and Type 2 Diabetes Mellitus. Diabetology & Metabolic Syndrome, 6, 99.
https://doi.org/10.1186/1758-5996-6-99 |
| [17] | Xu, J., Zhao, Y.H., Chen, Y.P., et al. (2014) Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Scientific World Journal, 2014, Article ID: 926932. https://doi.org/10.1155/2014/926932 |
| [18] | Ortiga-Carvalho, T.M., Oliveira, K.J., Soares, B.A., et al. (2002) The Role of Leptin in the Regulation of TSH Secretion in the Fed State: In Vivo and in Vitro Studies. Journal of Endocrinolo-gy, 174, 121-125.
https://doi.org/10.1677/joe.0.1740121 |
| [19] | Maratou, E., Hadjidakis, D.J., Kollias, A., et al. (2009) Studies of Insu-lin Resistance in Patients with Clinical and Subclinical Hypothyroidism. European Journal of Endocrinology, 160, 785-790. https://doi.org/10.1530/EJE-08-0797 |
| [20] | Dimitriadis, G., Mitrou, P., Lambadiari, V., et al. (2006) Insu-lin Action in Adipose Tissue and Muscle in Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism, 91, 4930-4937. https://doi.org/10.1210/jc.2006-0478 |
| [21] | Sampaolo, G., Campanella, N., Catozzo, V., et al. (2014) Relationship between Hypothyroidism and Cholesterol Out of the Records of 1756 Patients. Recenti Progressi in Medic-ina, 105, 79-82. |
| [22] | Joffe, B.I. and Distiller, L.A. (2014) Diabetes Mellitus and Hypothyroidism: Strange Bedfellows or Mutual Companions? World Journal of Diabetes, 5, 901-904. https://doi.org/10.4239/wjd.v5.i6.901 |
| [23] | Wang, C. (2013) The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases. Journal of Diabetes Re-search, 2013, Article ID: 390534. https://doi.org/10.1155/2013/390534 |
| [24] | Rodondi, N., den Elzen, W.P., Bauer, D.C., et al. (2010) Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality. JAMA, 304, 1365-1374. https://doi.org/10.1001/jama.2010.1361 |
| [25] | 杨月莲, 陈世安, 龚磊, 等. 2型糖尿病患者颈动脉粥样硬化与血尿酸水平的相关性研究[J]. 现代生物医学进展, 2013, 13(22): 4322-4324. |
| [26] | 吴景程, 李晓华, 彭永德, 等. 2型糖尿病患者中亚临床甲状腺功能减退症与糖尿病血管并发症关系的研究[J]. 中华内分泌代谢杂志, 2010(4): 304-306. |
| [27] | Hak, A.E., Pols, H.A., Visser, T.J., et al. (2000) Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study. Annals of Internal Medicine, 132, 270-278. https://doi.org/10.7326/0003-4819-132-4-200002150-00004 |
| [28] | 涂燕平, 雷梦觉, 吴小和, 等. 亚临床甲状腺功能减退与冠心病患者血管内皮功能与炎症反应之间关系的研究[J]. 临床荟萃, 2011, 26(6): 491-493. |
| [29] | Turemen, E.E., Cetinarslan, B., Sahin, T., et al. (2011) Endothelial Dysfunction and Low Grade Chronic Inflammation in Subclinical Hypothyroidism Due to Autoimmune Thyroiditis. Endocrine Journal, 58, 349-354.
https://doi.org/10.1507/endocrj.K10E-333 |
| [30] | Monzani, F., Caraccio, N., Kozakowa, M., et al. (2004) Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subclinical Hypothyroidism: A Dou-ble-Blind, Placebo-Controlled Study. The Journal of Clinical Endocrinology & Metabolism, 89, 2099-2106. https://doi.org/10.1210/jc.2003-031669 |
| [31] | Biondi, B., Palmieri, E.A., Lombardi, G., et al. (2002) Effects of Sub-clinical Thyroid Dysfunction on the Heart. Annals of Internal Medicine, 137, 904-914. https://doi.org/10.7326/0003-4819-137-11-200212030-00011 |
| [32] | Monzani, F., Di Bello, V., Caraccio, N., et al. (2001) Effect of Levothyroxine on Cardiac Function and Structure in Subclinical Hypothyroidism: A Double Blind, Pla-cebo-Controlled Study. The Journal of Clinical Endocrinology & Metabolism, 86, 1110-1115. https://doi.org/10.1210/jcem.86.3.7291 |
| [33] | Takashima, N., Niwa, Y., Mannami, T., et al. (2007) Characterization of Subclinical Thyroid Dysfunction from Cardiovascular and Metabolic Viewpoints: The Suita Study. Circulation Jour-nal, 71, 191-195.
https://doi.org/10.1253/circj.71.191 |
| [34] | Han, C., He, X., Xia, X., et al. (2015) Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis. PLOS ONE, 10, e135233. https://doi.org/10.1371/journal.pone.0135233 |
| [35] | 王玫, 任安, 王东. 2型糖尿病合并亚临床甲减与糖尿病血管并发症相关性的研究[J]. 中国现代医学杂志, 2012, 22(36): 66-70. |
| [36] | Sochocka, M., Koutsouraki, E.S., Gasiorowski, K., et al. (2013) Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy. CNS & Neurological Disorders—Drug Targets, 12, 870-881. https://doi.org/10.2174/18715273113129990072 |
| [37] | Matsuura, E., Atzeni, F., Sarzi-Puttini, P., et al. (2014) Is Atherosclerosis an Autoimmune Disease? BMC Medicine, 12, Article No. 47. https://doi.org/10.1186/1741-7015-12-47 |
| [38] | Isguven, P., Gunduz, Y. and Kilic, M. (2016) Effects of Thyroid Autoimmunity on Early Atherosclerosis in Euthyroid Girls with Hashimoto’s Thyroiditis. Journal of Clinical Research in Pediatric Endocrinology, 8, 150-156.
https://doi.org/10.4274/jcrpe.2145 |
| [39] | Raterman, H.G., Voskuyl, A.E., Simsek, S., et al. (2013) Increased Pro-gression of Carotid Intima Media Thickness in Thyroid Peroxidase Antibodies-Positive Rheumatoid Arthritis Patients. European Journal of Endocrinology, 169, 751-757. https://doi.org/10.1530/EJE-13-0394 |
| [40] | Ichiki, T. (2016) Thyroid Hormone and Vascular Remodeling. Journal of Atherosclerosis and Thrombosis, 23, 266-275.
https://doi.org/10.5551/jat.32755 |
| [41] | Xiang, G.D., He, Y.S., Zhao, L.S., et al. (2006) Impairment of Endotheli-um-Dependent Arterial Dilation in Hashimoto’s Thyroiditis Patients with Euthyroidism. Clinical Endocrinology (Ox-ford), 64, 698-702.
https://doi.org/10.1111/j.1365-2265.2006.02531.x |
| [42] | Bano, A., Chaker, L., Mattace-Raso, F., et al. (2017) Thy-roid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study. Circulation Research, 121, 1392-1400.
https://doi.org/10.1161/CIRCRESAHA.117.311603 |
| [43] | Kapadia, K.B., Bhatt, P.A. and Shah, J.S. (2012) Associ-ation between Altered Thyroid State and Insulin Resistance. Journal of Pharmacology and Pharmacotherapeutics, 3, 156-160. |
| [44] | de Lange, P., Feola, A., Ragni, M., et al. (2007) Differential 3,5,3’-Triiodothyronine-Mediated Regulation of Uncoupling Protein 3 Transcription: Role of Fatty Acids. Endocrinology, 148, 4064-4072.
https://doi.org/10.1210/en.2007-0206 |
| [45] | Senese, R., Valli, V., Moreno, M., et al. (2011) Uncoupling Protein 3 Expression Levels Influence Insulin Sensitivity, Fatty Acid Oxidation, and Related Signaling Pathways. Pflügers Archiv, 461, 153-164.
https://doi.org/10.1007/s00424-010-0892-3 |
| [46] | Kadiyala, R., Peter, R. and Okosieme, O.E. (2010) Thyroid Dys-function in Patients with Diabetes: Clinical Implications and Screening Strategies. International Journal of Clinical Prac-tice, 64, 1130-1139.
https://doi.org/10.1111/j.1742-1241.2010.02376.x |
| [47] | Mitrou, P., Raptis, S.A. and Dimitriadis, G. (2010) Insulin Action in Hyperthyroidism: A Focus on Muscle and Adipose Tissue. Endocrine Reviews, 31, 663-679. https://doi.org/10.1210/er.2009-0046 |
