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骨微环境内细胞因子影响乳腺癌骨转移的机制研究
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Abstract:
骨转移作为晚期乳腺癌最常见的转移部位，其存在往往伴随着一系列骨相关事件，对患者生活造成了严重影响。骨微环境主要包括骨基质细胞(成骨细胞、破骨细胞等)、细胞外基质以及一系列细胞因子(甲状旁腺激素相关蛋白、白细胞介素、肿瘤坏死因子等)，在正常骨骼中维持着相对平衡状态。乳腺癌肿瘤细胞经过增殖、外溢后到达骨骼，会破坏此平衡，造成骨微环境的失调，影响骨代谢健康，从而增加乳腺癌骨转移的发生风险，也是促进骨转移进展的重要因素。因此探索并了解骨微环境内细胞及细胞因子与转移病灶的相互作用十分重要。本文主要阐述了骨微环境对乳腺癌骨转移发生发展机制的相关研究。
Bone metastasis is the most common metastatic site of advanced breast cancer. Its existence is of-ten accompanied by a series of skeletal-related events, which has a serious impact on patients’ lives. The bone microenvironment mainly includes bone matrix cells (osteoblast, osteoclast, etc.), extra-cellular matrix and a series of cytokines (parathyroid hormone related protein, interleukin, tumor necrosis factor, etc.), which maintain a relative balance in normal bones. Breast cancer tumor cells reach the bone after proliferation and overflow, which will disrupt this balance, cause the disorder of the bone microenvironment, affect the health of bone metabolism, and increase the risk of breast cancer bone metastasis, which is also an important factor in promoting the progress of bone metas-tasis. Therefore, it is very important to explore and understand the interaction between metastasis and cells or cytokines in the bone microenvironment. This article mainly elaborates the research on the mechanism of bone microenvironment on the occurrence and development of breast cancer bone metastasis.
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