基于壳聚糖导管的周围神经再生研究进展
Research Progress of Peripheral Nerve Regeneration Based on Chitosan Catheter

DOI: 10.12677/BP.2022.122017, PP. 148-153

Keywords: 周围神经再生，壳聚糖，导管，组织工程
Peripheral Nerve Regeneration, Chitosan, Catheter, Tissue Engineering

Full-Text   Cite this paper   Add to My Lib

Abstract:

如何促进周围神经损伤修复是一个棘手的临床难题，特别是长距离周围神经缺损。近年来随着材料科学的发展，已有多种不同材料制造的神经导管被用于治疗周围神经缺损，其中，壳聚糖由于其优良的生物性能而被广泛应用，研究表明联合使用各种可促神经再生的物质，可进一步提高治疗效果。本文就基于壳聚糖导管的混合策略、细胞接种、生物因子负载三个方面展开阐述。
How to promote the repair of peripheral nerve injury is a difficult clinical problem, especially for long-distance peripheral nerve defect. In recent years, with the development of materials science, nerve catheters made of various materials have been used to treat peripheral nerve injury, among which chitosan has been widely used due to its excellent biological properties. Studies have shown that the combined use of various substances that can promote nerve regeneration can further improve the therapeutic effect. In this paper, the mixing strategy, cell inoculation and biological factor loading based on chitosan catheter are described.

References

[1]	Li, G., Zheng, T., Wu, L., Han, Q., Lei, Y., Xue, L., Zhang, L., Gu, X. and Yang, Y. (2021) Bionic Microenviron-ment-Inspired Synergistic Effect of Anisotropic Micro-Nanocomposite Topology and Biology Cues on Peripheral Nerve Regeneration. Science Advances, 7, Article No. abi5812. https://doi.org/10.1126/sciadv.abi5812
[2]	Yuan, Y., Zhang, P., Yang, Y., Wang, X. and Gu, X. (2004) The Interaction of Schwann Cells with Chitosan Membranes and Fi-bers in Vitro. Biomaterials, 25, 4273-4278. https://doi.org/10.1016/j.biomaterials.2003.11.029
[3]	Li, G., Xue, C., Wang, H., Yang, X., Zhao, Y., Zhang, L. and Yang, Y. (2018) Spatially Featured Porous Chitosan Conduits with Mi-cropatterned Inner Wall and Seamless Sidewall for Bridging Peripheral Nerve Regeneration. Carbohydrate Polymers, 194, 225-235. https://doi.org/10.1016/j.carbpol.2018.04.049
[4]	Li, G., Xiao, Q., McNaughton, R., Han, L., Zhang, L., Wang, Y. and Yang, Y. (2017) Nanoengineered Porous Chitosan/CaTiO3 Hybrid Scaffolds for Accelerating Schwann Cells Growth in Peripheral Nerve Regeneration. Colloids and Surfaces B: Biointerfaces, 158, 57-67. https://doi.org/10.1016/j.colsurfb.2017.06.026
[5]	Jiang, M., Cheng, Q., Su, W., Wang, C., Yang, Y., Cao, Z. and Ding, F. (2014) The Beneficial Effect of Chitooligosaccharides on Cell Behavior and Function of Primary Schwann Cells Is Accompanied by Up-Regulation of Adhesion Proteins and Neurotrophins. Neurochemical Research, 39, 2047-2057. https://doi.org/10.1007/s11064-014-1387-y
[6]	Bak, M., Gutkowska, O.N., Wagner, E. and Gosk, J. (2017) The Role of Chitin and Chitosan in Peripheral Nerve Reconstruction. Polymers in Medicine, 47, 43-47. https://doi.org/10.17219/pim/75653
[7]	Huang, J., Lu, L., Zhang, J., Hu, X., Zhang, Y., Liang, W., Wu, S. and Luo, Z. (2012) Electrical Stimulation To Conductive Scaffold Promotes Axonal Regeneration and Remyelination in a Rat Model of Large Nerve Defect. PLOS ONE, 7, Article ID: e39526. https://doi.org/10.1371/journal.pone.0039526
[8]	Li, R., Li, D.H., Zhang, H.Y., Wang, J., Li, X.K. and Xiao, J. (2020) Growth Factors-Based Therapeutic Strategies and Their Underlying Signaling Mechanisms for Peripheral Nerve Regeneration. Acta Pharmacologica Sinica, 41, 1289-1300. https://doi.org/10.1038/s41401-019-0338-1
[9]	Patel, N.P., Lyon, K.A. and Huang, J.H. (2018) An Update-Tissue Engineered Nerve Grafts for the Repair of Peripheral Nerve Injuries. Neural Regeneration Research, 13, 764-774. https://doi.org/10.4103/1673-5374.232458
[10]	Li, G., Han, Q., Lu, P., Zhang, L., Zhang, Y., Chen, S., Zhang, P., Zhang, L., Cui, W., Wang, H. and Zhang, H. (2020) Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration. Research, 2020, Article ID: 2603048. https://doi.org/10.34133/2020/2603048
[11]	Ichihara, S., Inada, Y., Nakada, A., Endo, K., Azuma, T., Nakai, R., Tsutsumi, S., Kurosawa, H. and Nakamura, T. (2009) Development of New Nerve Guide Tube for Repair of Long Nerve Defects. Tissue Engineering Part C: Methods, 15, 387-402. https://doi.org/10.1089/ten.tec.2008.0508
[12]	Fujimaki, H., Uchida, K., Inoue, G., Matsushita, O., Nemoto, N., Miyagi, M., Inage, K., Takano, S., Orita, S., Ohtori, S., Tanaka, K., Sekiguchi, H. and Takaso, M. (2020) Polyglycolic Acid-Collagen Tube Combined with Collagen-Binding Basic Fibroblast Growth Factor Accelerates Gait Recovery in a Rat Sciatic Nerve Critical-Size Defect Model. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108, 326-332. https://doi.org/10.1002/jbm.b.34391
[13]	Wang, X., Hu, W., Cao, Y., Yao, J., Wu, J. and Gu, X. (2005) Dog Sci-atic Nerve Regeneration Across A, 30-Mm Defect Bridged by a Chitosan/PGA Artificial Nerve Graft. Brain, 128, 1897-1910. https://doi.org/10.1093/brain/awh517
[14]	Shen, H., Shen, Z.L., Zhang, P.H., Chen, N.L., Wang, Y.C., Zhang, Z.F. and Jin, Y.Q. (2010) Ciliary Neurotrophic Factor-Coated Polylactic-Polyglycolic Acid Chitosan Nerve Conduit Promotes Peripheral Nerve Regeneration in Canine Tibial Nerve Defect Repair. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 95B, 161-170. https://doi.org/10.1002/jbm.b.31696
[15]	Mokarizadeh, A., Mehrshad, A. and Mohammadi, R. (2016) Local Polyethylene Glycol in Combination with Chitosan Based Hybrid Nan-ofiber Conduit Accelerates Transected Peripheral Nerve Regeneration. Journal of Investigative Surgery, 29, 167-174. https://doi.org/10.3109/08941939.2015.1098758
[16]	Huang, Z., Kankowski, S., Ertekin, E., Almog, M., Nevo, Z., Rochkind, S. and Haastert-Talini, K. (2021) Modified Hyaluronic Acid-Laminin-Hydrogel as Luminal Filler for Clinical-ly Approved Hollow Nerve Guides in a Rat Critical Defect Size Model. International Journal of Molecular Sciences, 22, Article No. 6554. https://doi.org/10.3390/ijms22126554
[17]	Mingyu, C., Kai, G., Jiamou, L., Yandao, G., Nanming, Z. and Xiufang, Z. (2004) Surface Modification and Characterization of Chitosan Film Blended with Poly-L-Lysine. Journal of Bio-materials Applications, 19, 59-75. https://doi.org/10.1177/0885328204043450
[18]	Chen, T.K., Jiang, H.M., Zhu, Y.B., Chen, X.L., Zhang, D., Li, X., Shen, F.C., Xia, H.Y., Min, Y.G. and Xie, K. (2021) Highly Ordered, 3D Tissue Engineering Scaffolds As a Versa-tile Culture Platform for Nerve Cells Growth. Macromolecular Bioscience, 21, Article ID: 2100047. https://doi.org/10.1002/mabi.202100047
[19]	Huang, C.W., Lu, S.Y., Huang, T.C., Huang, B.M., Sun, H.S., Yang, S.H., Chuang, J.I., Hsueh, Y.Y., Wu, Y.T. and Wu, C.C. (2020) FGF9 Induces Functional Differentiation To Schwann Cells From Human Adipose Derived Stem Cells. Theranostics, 10, 2817-2831. https://doi.org/10.7150/thno.38553
[20]	Boecker, A.H., Van Neerven, S.G., Scheffel, J., Tank, J., Altinova, H., Seidensticker, K., Deumens, R., Tolba, R., Weis, J., Brook, G.A., Pallua, N. and Bozkurt, A. (2016) Pre-Differentiation of Mesenchymal Stromal Cells in Combination with a Microstructured Nerve Guide Supports Peripheral Nerve Regener-ation in the Rat Sciatic Nerve Model. European Journal of Neuroscience, 43, 404-416. https://doi.org/10.1111/ejn.13052
[21]	Zhao, Y., Tian, C., Wu, P., Chen, F., Xiao, A., Ye, Q., Shi, X., Wang, Z., Han, X. and Chen, Y. (2021) Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regener-ation. Tissue Engineering Part A, 28, 225-238. https://doi.org/10.1089/ten.tea.2021.0068
[22]	Moattari, M., Kouchesfehani, H.M., Kaka, G., Sadraie, S.H., Naghdi, M. and Mansouri, K. (2018) Chitosan-Film Associated with Mesenchymal Stem Cells Enhanced Regeneration of Pe-ripheral Nerves: A Rat Sciatic Nerve Model. Journal of Chemical Neuroanatomy, 88, 46-54. https://doi.org/10.1016/j.jchemneu.2017.10.003
[23]	Ding, F., Wu, J.A., Yang, Y.M., Hu, W., Zhu, Q., Tang, X., Liu, J. and Gu, X.S. (2010) Use of Tissue-Engineered Nerve Grafts Consisting of a Chitosan/Poly(Lactic-Co-Glycolic Acid)-Based Scaffold Included with Bone Marrow Mesenchymal Cells for Bridging, 50-Mm Dog Sciatic Nerve Gaps. Tissue Engineering Part A, 16, 3779-3790. https://doi.org/10.1089/ten.tea.2010.0299
[24]	Xue, C.B., Hu, N., Gu, Y., Yang, Y.M., Liu, Y., Liu, J.E., Ding, F. and Gu, X.S. (2012) Joint Use of a Chitosan/PLGA Scaffold and MSCs To Bridge an Extra Large Gap in Dog Sciatic Nerve. Neurorehabilitation and Neural Repair, 26, 96-106. https://doi.org/10.1177/1545968311420444
[25]	Fadia, N.B., Bliley, J.M., DiBernardo, G.A., Crammond, D.J., Schilling, B.K., Sivak, W.N., Spiess, A.M., Washington, K.M., Waldner, M., Liao, H.T., James, I.B., Minteer, D.M., Tompkins-Rhoades, C., Cottrill, A.R., Kim, D.Y., Schweizer, R., Bourne, D.A., Panagis, G.E., Schusterman, M.A., Egro, F.M., Campwala, I.K., Simpson, T., Weber, D.J., Gause, T., Brooker, J.E., Josyula, T., Guevara, A.A., Repko, A.J., Mahoney, C.M. and Marra, K.G. (2020) Long-Gap Peripheral Nerve Repair Through Sustained Release of a Neurotrophic Factor in Nonhuman Primates. Science Translational Medi-cine, 12, Article No. aav7753. https://doi.org/10.1126/scitranslmed.aav7753
[26]	Kong, Y.F., Shi, W., Zhang, D.Z., Jiang, X.P., Kuss, M., Liu, B., Li, Y.L. and Duan, B. (2021) Injectable, Antioxidative, and Neurotrophic Fac-tor-Deliverable Hydrogel for Peripheral Nerve Regeneration and Neuropathic Pain Relief. Applied Materials Today, 24, Article ID: 101090. https://doi.org/10.1016/j.apmt.2021.101090
[27]	Patel, M., Mao, L., Wu, B. and VandeVord, P.J. (2007) GDNF-Chitosan Blended Nerve Guides: A Functional Study. Journal of Tissue Engineering and Regenera-tive Medicine, 1, 360-367. https://doi.org/10.1002/term.44
[28]	Shang, J., Qiao, H., Hao, P., Gao, Y., Zhao, W., Duan, H., Yang, Z. and Li, X. (2019) BFGF-Sodium Hyaluronate Collagen Scaffolds Enable the Formation of Nascent Neural Networks After Adult Spinal Cord Injury. Journal of Biomedical Nanotechnology, 15, 703-716. https://doi.org/10.1166/jbn.2019.2732
[29]	Li, M., Zhao, W., Gao, Y., Hao, P., Shang, J., Duan, H., Yang, Z. and Li, X. (2019) Differentiation of Bone Marrow Mesenchymal Stem Cells into Neural Lineage Cells Induced by BFGF-Chitosan Controlled Release System. BioMed Research International, 2019, Article ID: 5086297. https://doi.org/10.1155/2019/5086297
[30]	Duan, H., Li, X., Wang, C., Hao, P., Song, W., Li, M., Zhao, W., Gao, Y. and Yang, Z. (2016) Functional Hyaluronate Collagen Scaffolds Induce NSCs Differentiation into Functional Neu-rons in Repairing the Traumatic Brain Injury. Acta Biomaterialia, 45, 182-195. https://doi.org/10.1016/j.actbio.2016.08.043
[31]	Woodbury, M.E. and Ikezu, T. (2014) Fibroblast Growth Fac-tor-2 Signaling in Neurogenesis and Neurodegeneration. Journal of Neuroimmune Pharmacology, 9, 92-101. https://doi.org/10.1007/s11481-013-9501-5

Full-Text