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肥胖在2型糖尿病发病机制中的探索
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Abstract:
2型糖尿病(Type 2 diabetes mellitus, T2DM)发病机制主要是胰岛素分泌缺陷即绝对缺乏和胰岛素抵抗即利用障碍，其发病的关键因素是超重与肥胖所致的胰岛素抵抗。肥胖症(obesity)是指机体脂肪总含量过多和(或)局部含量增多及分布异常，是一种由遗传和环境等因素共同引起、并对健康造成一定影响的慢性代谢性疾病。胰岛素抵抗(Insulin resistance, IR)是指胰岛素作用的目标器官如肝脏、脂肪组织和骨骼肌对于正常的胰岛素水平敏感性下降，使组织对葡萄糖的摄取和利用效率减低。肥胖在研究T2DM的发生发展中逐渐成为不可或缺的角色。此文旨在总结肥胖在2型糖尿病发病机制中所扮演的角色并总结新的治疗方法及代谢指标。
The pathogenesis of type 2 diabetes mellitus (T2DM) is mainly insulin secretion deficiency (abso-lute deficiency) and insulin resistance (utilization disorder). The key factor of its pathogenesis is insulin resistance caused by overweight and obesity. Obesity is a chronic metabolic disease caused by genetic and environmental factors, which has a certain impact on health. Insulin resistance re-fers to the decrease in the sensitivity of target organs of insulin action, such as liver, adipose tissue and skeletal muscle, to normal insulin levels, resulting in the decrease of glucose uptake and utili-zation efficiency of tissues. Obesity has gradually become an indispensable role in the study of the occurrence and development of T2DM. The purpose of this article is to summarize the role of obesity in the pathogenesis of type 2 diabetes and to summarize new treatment methods and metabolic in-dicators.
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