Introduction: DNA repair enzymes continuously monitor DNA to correct damaged
nucleotide residues generated by exposure to environmental mutagenic and
cytotoxic compounds or carcinogens. Our objective was to investigate the
association among XRCC1 (Arg399Gln and Arg194Trp), XRCC3 (Thr241Met), XPD-ERCC2
(Lys751Gln), APE1 (Asp241Glu), PARP-ADPRT (Val762Ala) DNA repair gene
polymorphisms and lung cancer in Turkish population. MaterialsandMethods: Our patient group consists of 90 patients with lung cancer and
the control group had 100 healthy individuals all of those smoking. DNA was
extracted using the whole blood samples. PCR- RFLP technique was used to
investigate the polymorphisms on target genes. Results: There was no
significant difference in the genotype distributions of XPD Lys751Gln, XRCC1
Arg194Trp, XRCC3 Thr241Met, APE1 Asp241Glu between lung cancer patients and
controls for each polymorphism (p > 0.05). However, there was a significant difference between the genotype
distributions of XRCC1 Arg399Gln, and PARP Val762Ala in patients and the control
group (p > 0.05). Discussion: Only the polymorphisms of XRCC1 codon 399 and PARP Val762Ala alleles are
associated with the risk of lung cancer. Other genotypes were not related to lung
cancer.
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